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Biomedical subjects

Jesper Hjortdal

Publications and source records attributed to Jesper Hjortdal.

7 recordsLinked to original sources

The power of a cylinder in an oblique meridian: revisiting an old controversy.

The sine-squared correlation states that the cylinder power in an oblique meridian forming an angle beta with the axis of the cylinder is reduced to sin(2)beta of the maximal power. The sine-squared relationship is fundamental in paraxial optics, but its validity has repeatedly been questioned during the last century. It appears that two powers are operative in an oblique meridian, curvital and torsional. Curvital power is responsible for refraction in the plane of the meridian, while the torsional component twists the light out of that plane. Curvital power is the traditional power concept, while torsional power has only recently been described. The long-standing criticism of the sine-squared correlation is based on the erroneous assumption that only curvital power is operational in paraxial imagery. Curvital and torsional power are both derived from the sine-squared correlation. The concept of these dual powers repudiates the criticism and is in complete accordance with paraxial optics.

Astigmatism↗

Central corneal thickness in high myopia.

PURPOSE: To examine if central corneal thickness (CCT) is different in emmetropia and high myopia. METHODS: 57 emmetropic subjects (0 to + 1.5 D) and 48 high myopes (all more than - 6 D in spherical equivalent refraction) were studied. CCT was measured by a Haag-Streit Optical Low-Coherence Reflectometry (OLCR) pachymeter, a recently developed high precision pachymeter with a standard deviation (SD) for repeated measurements of 1 microm. RESULTS: Mean CCT for the emmetropic group was 538.6 microm (SD = 32.1), and for the myopic group 527.7 microm (SD = 35.0). Neither the mean CCT nor the variance from the two groups showed a statistically significant different (p > 0.05). CONCLUSION: CCT is not systematically altered in myopia. The process by which the myopia progresses does not to a measurable degree influence the central cornea.

Adolescent↗

Nordic research in ophthalmology.

Nordic ophthalmologists and vision scientists are active in many fields of eye research. This is most evident at the biannual Nordic Congress of Ophthalmology, most recently held in Malmö in June 2004. The authors here review some of the research in vision and ophthalmology presented at this meeting or published recently by Nordic scientists. This paper does not represent a comprehensive review of all Nordic research in the field, but attempts to give an overview of some of the activities underway in eye research in this part of the world.

Animals↗

Corneal thickness: measurement and implications.

The thickness of the cornea was reported in more than 100-year-old textbooks on physiological optics (Helmholtz, Gullstrand). Physiological interest was revived in the 1950s by David Maurice, and over the next 50 years, this 'simple' biological parameter has been studied extensively. Several techniques for its measurement have been described and physiological and clinical significance have been studied. In this review, the different methods and techniques of measurement are briefly presented (optical, ultrasound). While the corneal thickness of many animals are the same over a considerable part of the surface, in the human cornea anterior and posterior curvature are not concentric giving rise to a problem of definition. Based on this the precision and accuracy of determining the central corneal thickness are discussed. Changes in corneal thickness reflects changes in function of the boundary layers, in particular the endothelial barrier. The absolute value of thickness is of importance for the estimation of IOP but also in diagnosis of corneal and systemic disorders. Finally it is discussed to what extent the thickness is a biometric parameter of significance, e.g. in the progression of myopia or in the development of retinal detachment.

Cornea↗

Pupil size and night vision disturbances after LASIK for myopia.

PURPOSE: To examine whether standardized, preoperative evaluation of pupil sizes can predict the risk of night vision visual disturbances after bilateral laser in situ keratomileusis (LASIK) for myopia. METHODS: A prospective study was carried out involving 46 patients who underwent bilateral LASIK for myopia. Pupil sizes were measured before surgery using an infrared pupillometer under standardized settings. Pre- and postoperative refraction and best spectacle-corrected visual acuity (BSCVA) were registered. At the 3-month follow-up visit, the patients completed a questionnaire regarding night vision pre- and postoperatively. RESULTS: The mean bilateral, spherical equivalent refraction (SE) was - 8.76 D (range 6.32 to - 12.0 D) preoperatively, and - 1.69 D (range 0 to - 4.38 D) postoperatively. The mean bilateral BSCVA was not changed by the operations. We found a significant correlation between large scotopic pupil sizes and the impression of worsened night vision (p < 0.01). A significant correlation between gender (males) and subjectively reduced night vision postoperatively was also found (p < 0.05). CONCLUSION: Large pupil size measured preoperatively is correlated with an increased frequency of subjectively experienced post-LASIK visual disturbances during scotopic conditions. We recommend preoperative evaluation of pupil size in all patients prior to LASIK surgery.

Adult↗

Are cataract and iris atrophy toxic complications of medical treatment of acanthamoeba keratitis?

PURPOSE: Two cases of acanthamoeba keratitis with almost identical clinical courses developed mature cataract and iris atrophy after prolonged treatment with chlorhexidine 0.02% and propamidine isethionate 0.1%. It is suggested that these complications were caused by the chemicals, rather than resulting from the amoebae-induced inflammation. METHODS: Penetrating keratoplasty was performed in both cases when perforation from peripheral ulceration was threatening. RESULTS AND CONCLUSIONS: The immediate results were good. From these two cases it seems possible that there is a maximum level of intensity of the medical treatment and also that surgery should be considered at an earlier stage, before intraocular complications develop.

Acanthamoeba Keratitis↗