Biomedical subjects

Jialin He

Publications and source records attributed to Jialin He.

3 recordsLinked to original sources

PubMed2024

Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases.

Crosstalk between N6-methyladenosine (m6A) and epigenomes is crucial for gene regulation, but its regulatory directionality and disease significance remain unclear. Here, we utilize quantitative trait loci (QTLs) as genetic instruments to delineate directional maps of crosstalk between m6A and two epigenomic traits, DNA methylation (DNAme) and H3K27ac. We identify 47 m6A-to-H3K27ac and 4,733 m6A-to-DNAme and, in the reverse direction, 106 H3K27ac-to-m6A and 61,775 DNAme-to-m6A regulatory loci, with differential genomic location preference observed for different regulatory directions. Integrating these maps with complex diseases, we prioritize 20 genome-wide association study (GWAS) loci for neuroticism, depression, and narcolepsy in brain; 1,767 variants for asthma and expiratory flow traits in lung; and 249 for coronary artery disease, blood pressure, and pulse rate in muscle. This study establishes disease regulatory paths, such as rs3768410-DNAme-m6A-asthma and rs56104944-m6A-DNAme-hypertension, uncovering locus-specific crosstalk between m6A and epigenomic layers and offering insights into regulatory circuits underlying human diseases.

Humans↗

PubMed2004

Clinical observation in 102 cases of chronic pelvic inflammation treated with qi jie granules.

OBJECTIVE: To observe the therapeutic effects of Qi Jie Granule [see: symbol text] on chronic pelvic inflammation. METHOD: The therapeutic effect, T-lymphocytic subgroups and indexes of blood rheology were observed when 102 cases of chronic pelvic inflammation in the treatment group were treated with Qi Jie Granule, and another 70 cases were treated with Qian Jin Pian as the controls. RESULTS: The total effective rate was 96.08% in the treatment group, but 84.29% in the control group with a significant difference between the two groups (P < 0.01). Qi Jie Granule was also found effective in improving blood viscosity and regulating T-lymphocytic subgroups, and the difference before and after the treatment was also very significant (P < 0.05 or P < 0.01). CONCLUSION: The nature of chronic pelvic inflammation is qi deficiency and blood stasis in accordance with the theory of traditional Chinese medicine (TCM). As a drug that is indicated for chronic pelvic inflammation, its mechanism may be related to the improved blood circulation, accelerated inflammatory absorption and regulated immune function.

Adult↗

PubMed2002

[Surgical treatment for well-differentiated thyroid carcinoma invading the laryngotrachea].

OBJECTIVE: To discuss the method of surgical treatment for well-differentiated thyroid carcinoma (WDTC) invading the laryngotrachea. METHODS: According to surgical procedure, 21 patients with WDTC invading the laryngotrachea were divided into tumor radical removal group (Group A, n = 5), tumor chisel group (Group B, n = 11) and tumor debulking group (Group C, n = 5). RESULTS: The overall 3-, 5- and 7-year survival rates were 81.0% (17/21), 61.9% (13/21) and 42.9% with better result in Group A (P < 0.001) and Group B (P < 0.03) than in Group C, however, without any significance between Groups A and B (P > 0.05). CONCLUSION: Conservative operation should be considered in most patients with well differentiated thyroid carcinoma invading the laryngotrachea. Only in the presence of intraluminal invasion in the trachea causing hemoptysis and airway obstruction does it require radical operation.

Adult↗