Biomedical subjects
Publications and source records attributed to Jian-Hua Zou.
A new labdane type diterpenoid, (8alpha,13R)-epoxy-14-labden-6beta,7beta-diol-7-beta-D-(4'-acetyl) fucopyranoside, named ledebourene 1, was isolated from the flowers of Trollius ledebouri. The absolute stereostructure was elucidated on the basis of the spectroscopic analysis.
Five new cyclolanostane triterpene glycosides, 12-deacetyloxy-15alpha-hydroxy-23-epi-26-deoxyactein, 12-deacetyloxy-23-epi-26-deoxyactein, 24-O-acetyldahurinol-3-O-beta-D-xylopyranoside, 12beta-hydroxycimigenol-3-O-beta-D-xylopyranosyl-(1-->3)-beta-D-xylopyranoside, 25-anhydrocimicigenol-3-O-beta-D-(2'-O-acetyl)xylopyranoside, were isolated from the rhizome of Souliea vaginata collected in China. Their structures were elucidated by spectroscopic techniques, including 2D NMR spectra, and in the case of 5, by chemical correlation.
A new oleanane-type triterpenoid (1) and five known pentacyclic triterpenoids (2-6) were isolated from the leaves of Excoecaria agallocha. Their structures were elucidated by spectroscopic analyses. The new compound was characterized as 3beta-[(2E,4E)-5-oxo-decadienoyloxy]-olean-12-ene (1). Compounds 1-6 were found inactive in vitro against several human cancer cell lines.
The ethanol extract of the flowers of Trollius ledebouri yielded four flavone C-glycosides, 2''-O-vanilloylvitexin, 2''-O-feruloylorientin, 2''-O-beta-L-galactopyranosylvitexin, and 2''-O-beta-L-galactopyranosylorientin, along with known compounds, 6''-O-acetylorientin, 2''-O-(4'''-hydroxybenzoyl)vitexin, vitexin, and orientin. Their structures were elucidated by means of UV, IR, MS and NMR spectroscopic analyses.
OBJECTIVE: To study the chemical constituents of the leaf of Isatis indigotica. METHOD: Chromatography and spectral analysis were respectively used to isolate and identify the constituents. RESULT: Three compounds were isolated from the ethanol extracts of theleaf of I. indigotica, and identified as indirubin, tryptanthrin and L-pyroglutamic acid. CONCLUSION: L-pyroglutamic acid was isolated from the genus for the first time, and tryptanthrin was isolated from the leaf of this plant for the first time.
Six new acylated flavone C-glycosides, 2''-O-(2'''-methylbutyryl)isoswertisin (1), 3''-O-(2'"-methylbutyryl)isoswertisin (2), 2''-O-(2'"-methylbutyryl)vitexin (3), 2''-O-(2'"-methylbutyryl)orientin (4), 2''-O-(3'",4'"-dimethoxybenzoyl)vitexin (5), and 2''-O-(3'",4'"-dimethoxybenzoyl)orientin (6), and the known flavone C-glycoside, isoswertisin, were isolated from the flowers of Trollius ledebouri. The structures of 1-6 were elucidated by spectroscopic methods.