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Biomedical subjects

Jian-Wei Pan

Publications and source records attributed to Jian-Wei Pan.

At least 19 recordsLinked to original sources
PubMed2006

Programmed cell death-involved aluminum toxicity in yeast alleviated by antiapoptotic members with decreased calcium signals.

The molecular mechanisms of aluminum (Al) toxicity and tolerance in plants have been the focus of ongoing research in the area of stress phytophysiology. Recent studies have described Al-induced apoptosis-like cell death in plant and animal cells. In this study, we show that yeast (Saccharomyces cerevisiae) exposed to low effective concentrations of Al for short times undergoes enhanced cell division in a manner that is dose and cell density dependent. At higher concentrations of Al or longer exposure times, Al induces cell death and growth inhibition. Several apoptotic features appear during Al treatment, including cell shrinkage, vacuolation, chromatin marginalization, nuclear fragmentation, DNA degradation, and DNA strand breaks, as well as concomitant cell aggregation. Yeast strains expressing Ced-9, Bcl-2, and PpBI-1 (a plant Bax inhibitor-1 isolated from Phyllostachys praecox), respectively, display more resistance to Al toxicity compared with control cells. Data from flow cytometric studies show these three antiapoptotic members do not affect reactive oxygen species levels, but decrease calcium ion (Ca(2+)) signals in response to Al stress, although both intracellular reactive oxygen species and Ca(2+) levels were increased. The data presented suggest that manipulation of the negative regulation process of programmed cell death may provide a novel mechanism for conferring Al tolerance.

Aluminum↗
PubMed2006

Experimental quantum error rejection for quantum communication.

We report an experimental demonstration of a bit-flip error-rejection protocol for error-reduced transfer of quantum information through a noisy quantum channel. In the experiment, an unknown state to be transmitted is encoded into a two-photon entangled state, which is then sent through an engineered noisy quantum channel. At the final stage, the unknown state is decoded by a parity measurement, successfully rejecting the erroneous transmission over the noisy quantum channel.

Journal Article↗
PubMed2006

Experimental quantum communication without a shared reference frame.

We present an experimental realization of a robust quantum communication scheme [Phys. Rev. Lett. 93, 220501 (2004)] using pairs of photons entangled in polarization and time. Our method overcomes errors due to collective rotation of the polarization modes (e.g., birefringence in optical fiber or misalignment), is insensitive to the phase's fluctuation of the interferometer, and does not require any shared reference frame including time reference, except the need to label different photons. The practical robustness of the scheme is further shown by implementing a variation of the Bennett-Brassard 1984 quantum key distribution protocol over 1 km optical fiber.

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PubMed2006

Experimental synchronization of independent entangled photon sources.

We report the generation of independent entangled photon pairs from two synchronized but mutually incoherent laser sources. The quality of synchronization is confirmed by observing a violation of Bell's inequality with 3.2 standard deviations in an entanglement swapping experiment. The techniques developed in our experiment are not only important for realistic linear optical quantum-information processing, but also enable new tests of local realism.

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PubMed2005

All-versus-nothing violation of local realism by two-photon, four-dimensional entanglement.

We develop and exploit a source of two-photon, four-dimensional entanglement to report the first two-particle all-versus-nothing test of local realism with a linear optics setup, but without resorting to a noncontextuality assumption. Our experimental results are in good agreement with quantum mechanics while in extreme contradiction to local realism. Potential applications of our experiment are briefly discussed.

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PubMed2005

Experimental quantum secret sharing and third-man quantum cryptography.

Quantum secret sharing (QSS) and third-man quantum cryptography (TQC) are essential for advanced quantum communication; however, the low intensity and fragility of the multiphoton entanglement source in previous experiments have made their realization an extreme experimental challenge. Here, we develop and exploit an ultrastable high intensity source of four-photon entanglement to report an experimental realization of QSS and TQC. The technology developed in our experiment will be important for future multiparty quantum communication.

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PubMed2005

Experimental realization of optimal asymmetric cloning and telecloning via partial teleportation.

We report an experimental realization of both optimal asymmetric cloning and telecloning of single photons by making use of partial teleportation of an unknown state. In the experiment, we demonstrate that, conditioned on the success of partial teleportation of single photons, not only the optimal asymmetric cloning can be accomplished, but also one of two outputs can be transferred to a distant location, realizing the telecloning. The experimental results represent a novel way to achieve quantum cloning and may have potential applications in the context of quantum communication.

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PubMed2005

Experimental free-space distribution of entangled photon pairs over 13 km: towards satellite-based global quantum communication.

We report free-space distribution of entangled photon pairs over a noisy ground atmosphere of 13 km. It is shown that the desired entanglement can still survive after both entangled photons have passed through the noisy ground atmosphere with a distance beyond the effective thickness of the aerosphere. This is confirmed by observing a spacelike separated violation of Bell inequality of 2.45+/-0.09. On this basis, we exploit the distributed entangled photon source to demonstrate the Bennett-Brassard 1984 quantum cryptography scheme. The distribution distance of entangled photon pairs achieved in the experiment is for the first time well beyond the effective thickness of the aerosphere, hence presenting a significant step towards satellite-based global quantum communication.

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PubMed2005

Experimental demonstration of a nondestructive controlled-NOT quantum gate for two independent photon qubits.

Universal logic gates for two quantum bits (qubits) form an essential ingredient of quantum information processing. However, photons, one of the best candidates for qubits, suffer from a lack of strong nonlinear coupling, which is required for quantum logic operations. Here we show how this drawback can be overcome by reporting a proof-of-principle experimental demonstration of a nondestructive controlled-NOT (CNOT) gate for two independent photons using only linear optical elements in conjunction with single-photon sources and conditional dynamics. Moreover, we exploit the CNOT gate to discriminate all four Bell states in a teleportation experiment.

Journal Article↗
PubMed2005

Expression of endothelial nitric oxide synthase and vascular endothelial growth factor in association with neovascularization in human primary astrocytoma.

OBJECTIVE: To investigate the relationship between the expression of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and angiogenesis in primary astrocytoma. METHODS: Thirty-seven primary astrocytomas and 4 astrocytic hyperplasia samples were collected and divided into three groups according to histological grade. The expression of eNOS, VEGF and factor VIII related antigen (FVIIIRAg) were assayed by immunohistochemistry. Microvascular density was assessed by FVIIIRAg immunoreactivity. The intensity of immunoreactivity was graded according to the percentage of positive tumor cells. RESULTS: No eNOS and VEGF were expressed in the astrocytes and vascular endothelium in astrocytic hyperplasia. The expression of eNOS or VEGF was light in low-grade astrocytoma and strong in glioblastoma. eNOS expression in astrocytoma was very positively correlated with VEGF. eNOS and VEGF expression in anaplastic astrocytoma was median in contrast to the low grade astrocytoma and glioblastoma. Lower microvascular density was found in low grade astrocytoma than that in higher grade malignant ones. The expressions of eNOS and VEGF were correlated with microvascular density and tumor malignancy. CONCLUSION: This finding suggests that eNOS and VEGF may have cooperative effect in tumor angiogenesis and play an important role in the pathogenesis of primary astrocytoma.

Adolescent↗
PubMed2004

Realization of a photonic controlled-NOT gate sufficient for quantum computation.

We report the first experimental demonstration of a quantum controlled-NOT gate for different photons, which is classically feed forwardable. In the experiment, we achieved this goal with only the use of linear optics, an entangled ancillary pair of photons, and postselection. The techniques developed in our experiment are of significant importance for quantum information processing with linear optics.

Journal Article↗
PubMed2004

Experimental demonstration of five-photon entanglement and open-destination teleportation.

Quantum-mechanical entanglement of three or four particles has been achieved experimentally, and has been used to demonstrate the extreme contradiction between quantum mechanics and local realism. However, the realization of five-particle entanglement remains an experimental challenge. The ability to manipulate the entanglement of five or more particles is required for universal quantum error correction. Another key process in distributed quantum information processing, similar to encoding and decoding, is a teleportation protocol that we term 'open-destination' teleportation. An unknown quantum state of a single particle is teleported onto a superposition of N particles; at a later stage, this teleported state can be read out (for further applications) at any of the N particles, by a projection measurement on the remaining particles. Here we report a proof-of-principle demonstration of five-photon entanglement and open-destination teleportation (for N = 3). In the experiment, we use two entangled photon pairs to generate a four-photon entangled state, which is then combined with a single-photon state. Our experimental methods can be used for investigations of measurement-based quantum computation and multi-party quantum communication.

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PubMed2004

De Broglie wavelength of a non-local four-photon state.

Superposition is one of the most distinctive features of quantum theory and has been demonstrated in numerous single-particle interference experiments. Quantum entanglement, the coherent superposition of states in multi-particle systems, yields more complex phenomena. One important type of multi-particle experiment uses path-entangled number states, which exhibit pure higher-order interference and the potential for applications in metrology and imaging; these include quantum interferometry and spectroscopy with phase sensitivity at the Heisenberg limit, or quantum lithography beyond the classical diffraction limit. It has been generally understood that in optical implementations of such schemes, lower-order interference effects always decrease the overall performance at higher particle numbers. Such experiments have therefore been limited to two photons. Here we overcome this limitation, demonstrating a four-photon interferometer based on linear optics. We observe interference fringes with a periodicity of one-quarter of the single-photon wavelength, confirming the presence of a four-particle mode-entangled state. We anticipate that this scheme should be extendable to arbitrary photon numbers, holding promise for realizable applications with entanglement-enhanced performance.

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PubMed2004

Bell's inequalities and quantum communication complexity.

We prove that for every Bell's inequality, including those which are not yet known, there always exists a communication complexity problem, for which a protocol assisted by states which violate the inequality is more efficient than any classical protocol. Violation of Bell's inequalities is the necessary and sufficient condition for quantum protocol to beat the classical ones.

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PubMed2004

Experimental nonlinear sign shift for linear optics quantum computation.

We have realized the nonlinear sign shift operation for photonic qubits. This operation shifts the phase of two photons reflected by a beam splitter using an extra single photon and measurement. We show that the conditional phase shift is (1.05+/-0.06)pi in clear agreement with theory. Our results show that, by using an ancilla photon and conditional detection, nonlinear optical effects can be implemented using only linear optical elements. This experiment represents an essential step for linear optical implementations of scalable quantum computation.

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PubMed2004

Root border cell development is a temperature-insensitive and Al-sensitive process in barley.

In vivo and in vitro experiments showed that border cell (BC) survival was dependent on root tip mucigel in barley (Hordeum vulgare L. cv. Hang 981). In aeroponic culture, BC development was an induced process in barley, whereas in hydroponic culture, it was a kinetic equilibrium process during which 300-400 BCs were released into water daily. The response of root elongation to temperatures (10-35 degrees C) was very sensitive but temperature changes had no great effect on barley BC development. At 35 degrees C, the root elongation ceased whereas BC production still continued, indicating that the two processes might be regulated independently under high temperature (35 degrees C) stress. Fifty microM Al could inhibit significantly BC development by inhibiting pectin methylesterase activity in the root cap of cv. 2000-2 (Al-sensitive) and cv. Humai 16 (Al-tolerant), but 20 microM Al could not block BC development in cv. Humai 16. BCs and their mucigel of barley had a limited role in the protection of Al-induced inhibition of root elongation, but played a significant role in the prevention of Al from diffusing into the meristems of the root tip and the root cap. Together, these results suggested that BC development was a temperature-insensitive but Al-sensitive process, and that BCs and their mucigel played an important role in the protection of root tip and root cap meristems from Al toxicity.

Aluminum↗
PubMed2003

Concentration of higher dimensional entanglement: qutrits of photon orbital angular momentum.

Enhancement of entanglement is necessary for most quantum communication protocols many of which are defined in Hilbert spaces larger than 2. In this work we present the experimental realization of entanglement concentration of orbital angular momentum entangled photons. We investigate the specific case of three dimensions and the possibility of generating different entangled states out of an initial state. The results presented here are of importance for pure states as well as for mixed states.

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