PubMed Health⌕ Search

Biomedical subjects

Jianchun Liao

Publications and source records attributed to Jianchun Liao.

6 recordsLinked to original sources
PubMed2006

[Tracheotomy in patients with liver transplantation].

OBJECTIVE: To investigate the indications, complications and their prevention of tracheotomy in patients with liver transplantation. METHOD: Data of 45 patients with liver transplantation who underwent tracheotomy were summarized. RESULT: Twenty-five patients(54.35%) succeeded in removing trachea cannula in one month after tracheotomy. Hemorrhage after tracheotomy occurred in 11 patients and haemostasis succeeded in all of them. Subcutaneous emphysema occurred in 2 patients. Infection of tracheal fistula occurred in 4 patients. Common bacterial culture of sputum was positive in 9 patients. No other operative complication occurred. CONCLUSION: Indications of tracheotomy in patient with liver transplantation include respiratory complication and lower respiratory tract infection. Postoperative hemorrhage and infection are the main complications and available measures should be adopted.

Adult↗
PubMed2005

Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization.

In vitro glycorandomization is a rapid chemoenzymatic strategy to diversify complex natural product scaffolds. The glycorandomization sugar activation pathway is dependent upon the efficient construction of diverse sugar-1-phosphate libraries. In the context of the previously evolved GalK Y371H "gatekeeper" mutation, the active site M173L mutation described herein presents a kinase with remarkably broadened substrate range to include 28 diverse natural and unnatural sugars. Among these new substrates, 6-azido-6-deoxy-galactose and 6-azido-6-deoxy-glucose present unique chemical probes to assess the utility of an E. coli Y371H/M173L-GalK-overproducing strain to generate unnatural sugar-1-phosphates in vivo. Remarkably, the in vivo conversion of both unnatural sugars rival that demonstrated in vitro. This notable in vivo success stands as the first step toward constructing short sugar-activation pathways in vivo and, ultimately, in vivo natural-product glycorandomization.

Binding Sites↗
PubMed2005

[Imaging analysis of the ethmoid roof].

OBJECTIVE: To discuss the image anatomy characters in the height and contour of the ethmoid roof. METHOD: Retrospective review of direct coronal sinus computed tomography (CT) scans in 160 patients. The height and contour of the fovea ethmoidalis, and the connection modes between ethmoidal roof and cribriform plate were examined. When an asymmetry in the height of the fovea ethmoidalis existed, this difference was quantified, and the difference between ethmoidal roof and cribriform plate was quantified in high type, too. RESULT: In 25 scans (15.63%), there was an asymmetry between the height of the fovea ethmoidalis on the right and left sides. Of these 25, 13 (52.00%) were lower on the right side. The difference between left and right was 2.35 mm. Sixty-two patients (38.75%) demonstrated a contour asymmetry with "flattening" of the ethmoid roof on one side. Horizontal type was 116 sides (36.25%), and high type was 204 sides (63.75%) in the connection modes between ethmoidal roof and cribriform plate. The difference was 2.80 mm in the high type. CONCLUSION: There were asymmetries in the height and contour of the right and left fovea ethmoidalis. The asymmetry was most often the result of a difference in contour with flattening of the fovea on one side. The high type was the most connection modes between ethmoidal roof and cribriform plate. This underscores the importance of careful preoperative and intraoperative review of paranasal sinus CT scans in patients undergoing endoscopoic sinus surgery.

Adult↗
PubMed2005

[Clinical anatomy study of olfaction correlative nerves].

OBJECTIVE: To find out the relation of the olfactory nerves, the optic nerve, and the nasal sinuses. Provide anatomic data for not to damnify olfactory nerves in the surgery. METHOD: To measure the olfactory nerves, the olfactory bulb, and olfactory tract on 16 adult cadaveric specimens, and observe the relation of the olfactory nerves, the optic nerve,and the nasal sinuses. RESULT: Length of the olfactory tract was (29.32 +/- 2.11) mm, width of the olfactory tract was (3.36 +/- 0.83) mm. The distance from the midpoint of the olfactory tract to the midline of the skull was (5.48 +/- 1.02) mm. The angle between olfactory tract and midline of the skull was (21.32 +/- 3.28) degrees. Length of the olfactory bulb was (10.43 +/- 2.35) mm, width of the olfactory bulb was (5.12 +/- 0.62) mm. 27/32 olfactory tracts were border upon with sphenoid sinus and ethmoid sinus, 3/32 olfactory tracts were border upon with ethmoid sinus, 2/32 olfactory tracts were border upon with frontal sinus. All olfactory tracts crossed the optic nerve at the internal meatus of optic nerve canal. The olfactory bulb and ethmoid bulb were on equal line. CONCLUSION: Almost all olfactory tracts were lied in the inboard of the orbital cavity, protect the roof of the nasal sinus to avoid damnify the olfactory nerves. It is easy to pull out the olfactory nerves when raising the cerebra in the operation of anterior cranial fossae.

Adult↗
PubMed2003

Antibiotic optimization via in vitro glycorandomization.

In nature, the attachment of sugars to small molecules is often used to mediate targeting, mechanism of action and/or pharmacology. As an alternative to pathway engineering or total synthesis, we report a useful method, in vitro glycorandomization (IVG), to diversify the glycosylation patterns of complex natural products. We have used flexible glycosyltransferases on nucleotide diphosphosugar (NDP-sugar) libraries to generate glycorandomized natural products and then applied chemoselective ligation to produce monoglycosylated vancomycins that rival vancomycin.

Anti-Bacterial Agents↗