Biomedical subjects

Jianxin Yue

Publications and source records attributed to Jianxin Yue.

13 recordsLinked to original sources

PubMed2006

Vascular endothelial growth factor165-regulated nasopharyngeal carcinoma cell lines invasion and migration involve expression and activation of matrix metalloproteinase-2.

The effect of vascular endothelial growth factor (VEGF) overexpression on matrix metalloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) cells in vitro and the possible mechanism involved were investigated, and the correlation between the expression of VEGF and MMP-2 in NPC evaluated. The NPC cells were transfected with PAd-trackVEGF165 plasmid. The expression levels of VEGF and MMP-2 mRNA and protein in NPC cells were detected by semi-quantitative RT-PCR and Western blot respectively. It was found that the expression of VEGF and MMP-2 mRNA and protein was significantly increased in NPC cells after transfection of VEGF165. It was concluded that the expression of VEGF was correlated to the in vitro invasion of NPC cells, and the induction of MMP-2 by VEGF was a key process of NPC cell invasion.

Cell Line, Tumor↗

PubMed2006

[The concentration and expression of IL-4, IL-5, IL-6, IL-8 in human nasal polyps tissues].

OBJECTIVE: To study the concentration and expression of IL-4, IL-5, IL-6, IL-8 in human nasal polyps tissues, and to explore the relationship between cytokines and the formative mechanism of nasal polyps. METHOD: The concentration and expression of IL-4, IL-5, IL-6, IL-8 in 54 cases with nasal polyps were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, and the middle turbinate mucosa from 22 patients with the deviation of nasal septum were used as the control. RESULT: The concentration of IL-5, IL-8 in nasal polyps tissues were significantly higher than that in normal middle turbinate mucosa (P < 0.01). There was no significant difference between the concentration of IL-6 in nasal polyps and that in normal control group (P > 0.05). No significant difference was found between the concentration of IL-4 in nasal polyps tissues with negative allergic skin test and that in control group, but the concentration of IL-4 was significantly higher in nasal polyps tissues with positive allergic skin test than in control group (P < 0.05). IL-4 was mostly found in lymphocytes and plasma cells in nasal polyps and IL-5 in eosinophils and lymphocytes. IL-6 and IL-8 were mostly found in nasal polyps epithelium and inflammatory cells, as was no difference between positive allergic skin test and negative one. CONCLUSION: IL-5 and IL-8 are the key cytokines in the formation of nasal polyps, and IL-4 is a key cytokine in nasal polyps with positive allergic skin test. IL-6 isn't an important cytokine in the formative mechanism of nasal polyps.

Adolescent↗

PubMed2006

[The diagnosis and treatment of special airway foreign body].

OBJECTIVE: The aim of this study was to discuss the diagnosis and treatment of special airway foreign body. METHOD: Clinical data of 69 patients with airway foreign body were analyzed,of which 45 patients underwent rigid bronchoscopy while another 24 patients underwent tracheotomy. RESULT: The operations succeeded in 43 of the 45 patients who underwent rigid bronchoscopy, while the other 2 patients died of respiratory failure because of the foreign body slipping off at the level of the glottis. All of the 24 other patients were cured, in which continuous saturation of blood oxygen below 90% occurred in 8 patients and turned normal after positive airway pressure in intensive care unit (ICU). The total cure rate reached 97.1%. CONCLUSION: Most of special foreign body in the airway can be taken out through tracheotomy under general anesthesia. If the foreign body is too big and irregularly, or the patients is too young or have the pulmonary atelectasis, it is much safer to remove foreign body by tracheotomy.

Adolescent↗

PubMed2006

[The effects of endoscopic sinus surgery on nasality and nasal patency].

OBJECTIVE: The purpose of this study was to describe the changes of resonance characteristics of the nasal cavity (including nasal sinuses) and nasal airway resistance (NAR) after endoscopic sinus surgery (ESS), through objective measurement of nasality and NAR before and after ESS. METHOD: Sixty- eight patients received the examinations of nasality and NAR using Nanometer and Atmos Rhinomanometry before and after ESS separately. RESULT: The nasality of patients with type III and type II stage 2, stage 3 chronic sinusitis was obviously improved ( P <0. 05), but still below the normal range 1 month after ESS. The nasality didn't recover to the normal level 3 months postoperatively. However the total NAR apparently decreased 1 months after ESS ( P <0. 01) and returned to normal 3 months postoperatively. Nasality and the total NAR of patients in type II stage 1 turned to normal 1 month after ESS. There are no distinctive changes in nasality and total NAR of type I stage 1 patients. CONCLUSION: The total NAR significantly decreased close to normal among the patients with severe sinus or/and nasal lesions after ESS, however nasality continued aberrant for a relatively long period. It is suggested that nasality can't be ameliorated immediately after ESS. On the contrary, it is possible to bring some undesirable effects to the professional voice users, such as announces, for the changed resonance characteristics of the nasal cavity due to the excessive destruction of its normal structure.

Adolescent↗

PubMed2006

[Clinical value of radionuclide imaging in differentiate the origin of cervical mass].

OBJECTIVE: To study the clinical value of thyroid imaging in differentiate the origin cervical mass. METHOD: Sixty-nine patients with cervical mass were subjected to 99mTc-pertechnetate imaging. 99Tc-MIBI hot spot imaging and perfusion imaging were performed in some of patients with cold or cool nodules. The findings of thyroid imaging were compared with follow up and histopathologic results. RESULT: Thirty-three of 69 patients were found with thyroid nodules, 36 patients mass were outside thyroid. Twelve of 33 thyroid nodules were found to be subacute thyroiditis. Two cases regarded as thyroglossal duct cyst were found to be ectopic thyroid glands. Twenty-seven of 36 masses out side thyroid were thyroglossal duct cysts. CONCLUSION: 99m Tc-pertechnetate imaging, 99mTc-MIBI hot spot imaging and perfusion imaging are useful to differentiate the origin of cervical mass, and differentiate ectopic thyroid from thyroglossal duct cyst.

Adolescent↗

PubMed2004

[Innovation and practice of college educational system in otorhinolaryngology].

OBJECTIVE: A series of educational innovation was performed in order to resolve the difficulties and conflict in the education of otorhinolaryngology of medical college. METHOD: The college educational system of otorhinolaryngology was established and put in practice in four grades of medical undergraduate students of 1997-2000 grade. RESULT: The scores and ability of medical students in otorhinolaryngology are improved significantly. Educational supervisors and the managers give high appreciation to the educational innovation of otorhinolaryngology. It was demonstrated that the innovated educational system is satisfactory for the college education of otorhinolaryngology. CONCLUSION: The innovated college educational system of otorhinolaryngology afford a good way to solve the difficulties and conflict in the college education of otorhinolaryngology. It is also valuable to other subjects in the clinical medical education of college education system.

Education, Medical, Undergraduate↗

PubMed2004

[Innovation of the curriculum system of otorhinolaryngology and its impact on education of capable medical students].

OBJECTIVE: The impact of the curriculum system innovation of otorhinolaryngology in the education of capable medical student was investigated. METHOD: The curriculum system of otorhinolaryngology in our college was innovated. The innovated curriculum of otorhinolaryngology was put in practice in 3 grades of undergraduate students and 2 grades of seven-year education system students. RESULT: The clinical practice ability and the mast of the knowledge of otorhinolaryngology were improved significantly. CONCLUSION: The principle of the curriculum system innovation of otorhinolaryngology in our college is effective and, therefore, valuable in education of potential and capable medical students for other subjects of clinical medicine.

Curriculum↗

PubMed2004

[Clinical therapic procedure of obstinate epistaxis].

OBJECTIVE: To investigate the clinical treatment consideration and the therapic procedure. METHOD: We analyze the clinical data of 171 cases of obstinate epistaxis in recent years, mainly the pathogeny, treatment consideration and therapic procedure. RESULT: Were two steps were selected to the therapeutics according to different causations: step one, using the methods including nasal septum rectification, nasal cavity microwave cauterization, the curative ratio were 87.20%, 91.25% respectively; step two, using the methods including DSA (digital subtraction angiography), ligation of the external carotid artery, arteria ethmoidalis clipping, the curative ratio were 90%, 100%, 100% respectively. CONCLUSION: The thought of taking two steps methods to treat the obstinate epistaxis is very clear, and the curative effect is satisfactory as well.

Adolescent↗

PubMed2003

[The study of the relationship between obstructive sleep apnea syndrome and positional nasal resistance].

OBJECTIVE: To study the nasal resistance in different position and its possible relationship to obstructive sleep apnea syndrome (OSAS). METHOD: The positional rhinomanometry and the detection of polysomnography were performed in 14 normal subjects, 20 snoring patients and 40 patients with OSAS. RESULT: The study reveals that: 1. the nasal resistance in seated position and in supine position of the patients with OSAS but without nasal diseases or snoring patients without nasal disease were higher than that of the normal group (P < 0.05). 2. The nasal resistance in seated position and in supine position of the patients with both OSAS and nasal disease were higher than that of the snoring patients with nasal disease (P < 0.05). 3. The nasal resistance in supine position was higher than the nasal resistance in seated position in all the groups (P < 0.05), even in the patients with OSAS (P < 0.01). 4. The AHI, waken intervals, snoring index of the patients both with OSAS and nasal disease were higher than those of the patients only with OSAS. CONCLUSION: Nasal resistance increased in the patients with snoring or OSAS and increased more in the supine position. Nasal resistance may be an important factor in the pathogenesis of OSAS.

Adult↗

PubMed2003

[Benefit of bilateral cochlear implantation on congenital prelingually deafened Chinese-speaking children].

OBJECTIVE: To evaluate the benefit of bilateral cochlear implants (BCIs) in prelingually deafened children on hearing rehabilitation as well as on speech and language development. METHOD: Two cases of congenital profound deaf children, who received unilateral cochlear implantation (CI, MEDEL C40+) on the age of 2 and 7.5, respectively, were performed secondary CI in the contralateral ear on their age of 5 and 9.5, respectively. One year after the secondary CI, the cochlear implant aided hearing threshold and speech discrimination rate were tested for both ears separately and together. The pronounce/speech distinct rate of the BCIs users were evaluated by their parents, surgeon and audiologist. RESULT: In comparison to unilateral aided ear, the mean hearing threshold at the frequency 250-4,000 Hz of the 2 cases with BCIs decreased by 13 dB and 11 dB, respectively. The speech discrimination rate of the BCIs users increased by 9% and 10%, respectively. The speech recognition in noise was improved. And their pronounce/speech distinct was improved. CONCLUSION: BCIs can provide a significant benefit in hearing, speech understanding, language development and pronounce/speech rehabilitation for prelingually deafened children.

Child↗

PubMed2003

[Integrated methods for assessing auditory nerve-auditory pathway integrity].

OBJECTIVE: To evaluate the feasibility and value of integrated methods to assess auditory pathway integrity. METHOD: Twenty-four cases of bilateral profoundly-deafened individuals who were considered as the candidates of cochlear implantation were included in this study. Auditory pathway integrity from these candidates of cochlear implantation were assessed with the integrated methods established by our team, which consist of 5 categories including 1. audiological test; 2. radiological imaging study; 3. ear-canal electric audiometry; 4. response to sound in daily life; and 5. speech development. RESULT: Twenty-three candidates who meet the criteria of auditory nerve-auditory pathway integrity received cochlear implantation with improved hearing and speech development postoperatively. The remainder one of the 24 candidates was diagnosed as bilateral absence of auditory nerve. The fault of cochlear implantation was avoided. CONCLUSION: The integrated methods for assessing auditory pathway integrity is feasible and valuable. Auditory nerve-auditory pathway integrity should be considered and included as one of the most important criteria for cochlear implantation candidate.

Acoustic Stimulation↗

PubMed2002

[Choice of the methods for inferior turbinectomy].

OBJECTIVE: To make clear the indications for each kind of inferior turbinectomy and to find out the best way of inferior turbinectomy. METHOD: The nasal resistances in pre-operation and post-operation were examined with rhinomanometer in 97 cases. The time of recovery, the symptoms remained and the complications after operation were recorded. RESULT: "Functional" inferior turbinectomy is characterized for its mild postoperation reaction, quick recovery and good therapeutic effect whereas the partial inferior turbinectomy is characterized for its serious reaction, bleeding and dryness after operation. CONCLUSION: There is a definite indication for each kind of inferior turbinectomy, but the indication of " functional" inferior turbinectomy is wide.

Adolescent↗

PubMed2002

[The comparison of treatment modalities for obstructive sleep apnea syndrome].

OBJECTIVE: To analyse the curative effects of various treatment modalities for obstructive sleep apnea syndrome. METHOD: 52 cases of patients were divided into two groups according to the methods of treatment. In group 1, 29 cases only received uvuloplatopharygoplasty (UPPP). In group 2, 23 cases received multimodality treatments by various combinations of UPPP, continuous positive airway pressure (CPAP) and the device of prosthetic dentitry. RESULT: The comparison between the short-term effects of two groups did not reveal statistically significant difference, but complications easily occurred in patients who did not receive CPAP before UPPP. The long-term effects of two groups were also compared, the difference was statistically significant. CONCLUSION: Multimodality treatment is an effective approach to improve the long-term effects of patients with OSAS.

Adult↗