Biomedical subjects

Jianyu Lu

Publications and source records attributed to Jianyu Lu.

5 recordsLinked to original sources

PubMed2026

Dynamic transcriptomic landscape from bulk RNA-seq reveals critical mmu-miR-181a-5p/hif1a and mmu-miR-101a-3p/col1a1 modules for deep second-degree burn wound healing.

Burn injuries constitute a significant global health challenge, with deep partial-thickness burns (deep second-degree) posing particular clinical concerns due to prolonged healing and high scarring risks stemming from reticular dermis damage. Current therapeutic strategies remain largely empirical, reflecting limited understanding of stage-specific regulatory mechanisms. This study systematically investigated the molecular basis of deep partial-thickness burn repair by establishing murine models and performing RNA-seq analysis across healing phases (0, 3, 7, 14 days post-burn, dpb). Integrated bioinformatics revealed pivotal ceRNA and PPI networks, identifying hif1a (hypoxia-responsive immunomodulator) and col1a1 (ECM remodeling hub) as nodal regulators. Mechanistically, mmu-miR-101a-3p and mmu-miR-181a-5p were validated as post-transcriptional repressors of col1a1 and hif1a, respectively. Our work pioneers the discovery of the mmu-miR-181a-5p/hif1a and mmu-miR-101a-3p/col1a1 axes as master regulators of burn repair, offering novel therapeutic targets. The multi-omics dataset and molecular networks established herein provide a foundational resource for wound healing research.

MicroRNAs↗

PubMed2006

High frame rate ultrasonic imaging system based on the angular spectrum principle.

A kind of high frame rate (HFR) 2D and 3D imaging method was developed by Jianyu Lu in 1997. Because only one transmission is required to construct a frame of image, this method can reach an ultra high frame rate (about 3750 volumes or frames per second for biological soft tissues at a depth of 200 mm). In this paper, a new HFR method is presented in the view of angular spectrum. Compared with conventional dynamic focusing method which uses delay-and-sum processing, and Lu's HFR method which uses a kind of special weighting on the received signal, the new method only uses the Fourier transform algorithm to construct image. So the system implementation of the method could be greatly simplified. During constructing image, several array beams with different parameter are used as transmitted signal, and the spectrum of a frame of image is obtained by synthesizing the image spectrums related to different transmit event. The simulation result shows that the solution not only suppresses the sidelobe of system greatly and obtains the high quality image, but also still keeps high frame rate to some extent.

Algorithms↗

PubMed2006

Study on application of complementary Golay code into high frame rate ultrasonic imaging system.

The high frame rate (HFR) ultrasonic imaging system, which is developed with limited diffraction beams, constructs images at a high frame rate. However the rectangular imaging area, to some extent, restricts the far field imaging information. At the same time, by virtue of one transmission event for constructing image, the system suffers from low SNR. In this paper we present a computationally efficient method to construct sector mode image and to increase the SNR in HFR system. The method uses orthogonal complementary Golay coded excitation to realize two transmit and receive events. Each emission simultaneously transmits two plane waves with different transmission angle. Then according to Golay code orthogonality, the received echo signals related to different angles are isolated and used to construct two images of different imaging area by HFR method. Finally the two images are synthesized to one frame of sector mode image.

Algorithms↗

PubMed2006

[Implementation of sector imaging mode with high signal-to-noise ratio in the high frame rate ultrasonic imaging system].

The high frame rate (HFR) ultrasonic imaging system, which is developed with limited diffraction beams, constructs images at a high frame rate. However the rectangular imaging area, to some extent, restricts the far field imaging information. At the same time, because of one transmission for constructing image, the system suffers from low SNR. In this paper we present a computationally efficient method to construct sector mode image and to increase the SNR in HFR system. The method uses Golay complementary sequence as excitation to realize two transmission events. Each event simultaneously transmits two plane waves with different transmission angle. Then the received echo signals related to different angle are separated according to orthogonality of Golay complementary sequence and used to construct two images of different area by HFR method. Finally the two images are synthesized to one frame of sector mode image.

Image Enhancement↗

PubMed2004

[Computer simulation of high frame rate ultrasonic imaging system based on the angular spectrum concept].

A high frame rate (HFR) ultrasonic imaging method developed by Jianyu Lu has been attracting attention in the related imaging area. Because a special weighting on the received signal is needed to implement this method, the imaging system is complicated. This paper presents a new kind of theroetical analysis for the HFR imaging system in view of the angular spectrum concept. Based on the study, the special weighting process can be replaced by Fourier transform. Computer simulation demonstrates the correctness of the analysis. It shows that the constructed images by the new method have the same high quality as those obtained by using the original HFR method while the system implementation is greatly simplified.

Computer Simulation↗