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Jiaxing Huang

Publications and source records attributed to Jiaxing Huang.

14 recordsLinked to original sources
PubMed2026

AI proteomics: from protein identification to virtual cells.

Artificial intelligence (AI) is transforming scientific research, including proteomics. In this Perspective, we highlight key mass spectrometry (MS)-based proteomics areas where AI is driving innovation, ranging from protein identification to building AI virtual cells. These include improving peptide and protein identification and quantification; characterizing protein-protein interactions and protein complexes; advancing spatial and perturbation proteomics; integrating multi-omics data; and, ultimately, enabling AI virtual cells. Finally, we call for global collaboration among data producers, data consumers and other stakeholders to establish an AI-friendly ecosystem for MS-based proteomics, laying the foundation for transformative advancements in proteomics driven by AI.

Proteomics↗
PubMed2006

A general method for assembling single colloidal particle lines.

We have developed a general method for assembling colloidal particles into one-dimensional lines of single particle thickness. Well-spaced, parallel single particle lines can be readily deposited on a substrate from a dilute Langmuir-Blodgett particle monolayer via a stick-slip motion of the water-substrate contact line. The particle density within the lines is controllable by the particle concentration in the monolayer as well as the pulling speed of the substrate. Lines of a great variety of materials and sizes, ranging from a few nanometers to a few micrometers, have been demonstrated. Multiple depositions create complex patterns such as cross lines, even of different particles. The ability of placing nanoparticles into one-dimensional arrays enables the construction of higher hierarchical device structures. For example, using gold nanoparticle seeds, vertical single nanowire arrays of silicon can be grown replicating the pattern of single particle lines.

Journal Article↗
PubMed2005

The intrinsic nanofibrillar morphology of polyaniline.

Polyaniline nanofibers are shown to form spontaneously during the chemical oxidative polymerization of aniline. The nanofibrillar morphology does not require any template or surfactant, and appears to be intrinsic to polyaniline synthesized in water. Two approaches--interfacial polymerization and rapidly-mixed reactions--have been developed to prepare pure nanofibers. The key is suppressing the secondary growth that leads to agglomerated particles. The effects of different dopant acids and solvents are discussed. Changing the dopant acid can be used to tune the diameters of the nanofibers between about 30 and 120 nm. Changing the organic solvent in interfacial polymerization reactions has little effect on the product. A brief discussion of the processibility of the nanofibers is presented. The possibility of creating nanofibrillar structures for selected polyaniline derivatives is also demonstrated.

Journal Article↗
PubMed2005

Spontaneous formation of nanoparticle stripe patterns through dewetting.

Significant advancement has been made in nanoparticle research, with synthetic techniques extending over a wide range of materials with good control over particle size and shape. A grand challenge is assembling and positioning the nanoparticles in desired locations to construct complex, higher-order functional structures. Controlled positioning of nanoparticles has been achieved in pre-defined templates fabricated by top-down approaches. A self-assembly method, however, is highly desirable because of its simplicity and compatibility with heterogeneous integration processes. Here we report on the spontaneous formation of ordered gold and silver nanoparticle stripe patterns on dewetting a dilute film of polymer-coated nanoparticles floating on a water surface. Well-aligned stripe patterns with tunable orientation, thickness and periodicity at the micrometre scale were obtained by transferring nanoparticles from a floating film onto a substrate in a dip-coating fashion. This facile technique opens up a new avenue for lithography-free patterning of nanoparticle arrays for various applications including, for example, multiplexed surface-enhanced Raman substrates and templated fabrication of higher-order nanostructures.

Gold↗
PubMed2005

Camouflaged carborane amphiphiles: synthesis and self-assembly.

A series of amphiphilic amine hydrochloride salts of B-polymethylated (camouflaged) (aminoalkyl)- and bis(aminoalkyl)carboranes have been designed and synthesized in high yield for the purpose of constructing novel carborane-based nanomaterials. Due to the distinct separation of the hydrophobic and hydrophilic regions within each salt, the mono- and disubstituted amphiphiles spontaneously self-assembled upon sonication into rod-shape micro/nanostructures in aqueous solutions. The effects of concentration, method of dispersion, solvent, chain length, counterion, ionic charge, and underlying carborane cage structure on the formation of the these rod products were investigated. The microrods have been studied by transmission electron microscopy (TEM), optical microscopy, X-ray powder diffraction (XRD), thermogravimetric/differential thermal analysis (TG/DTA), and FTIR. For the first time, this work clearly demonstrates the self-assembly of B-polymethylated carboranes into supramolecular structures.

Journal Article↗
PubMed2005

Polyaniline nanofiber/gold nanoparticle nonvolatile memory.

A nonvolatile plastic digital memory device based on nanofibers of the conjugated polymer polyaniline decorated with gold nanoparticles is reported. The device has a simple structure consisting of the plastic composite film sandwiched between two electrodes. An external bias is used to program the ON and OFF states of the device that are separated by a 3-orders-of-magnitude difference in conductivity. ON-OFF switching times of less than 25 ns are observed by electrical pulse measurements. The devices possess prolonged retention times of several days after they have been programmed. Write-read-erase cycles are also demonstrated. The switching mechanism is attributed to an electric-field-induced charge transfer from the polyaniline nanofibers to the gold nanoparticles. The active polymer layer is created by growing nanometer size gold particles within 30-nm-diameter polyaniline nanofibers using a redox reaction with chloroauric acid. This device combines two exciting research areas--nanoparticles and conducting polymers--to form a novel materials system with unique functionality.

Aniline Compounds↗
PubMed2004

Flash welding of conducting polymer nanofibres.

The absorption of light by a material generates heat through non-radiative energy dissipation and exothermic photochemical reactions. In nanostructured materials, the heat generated through photothermal processes will be confined within the individual nanostructures when heat transfer to neighbouring nanostructures and the environment is slow. This leads to unprecedented photothermal effects that cannot be observed in bulk materials, especially when a strong, pulsed light source is used. Here we demonstrate an enhanced photothermal phenomenon with conducting polymer nanofibres in which a camera flash causes instantaneous welding. Under flash irradiation, polyaniline nanofibres 'melt' to form a smooth and continuous film from an originally random network of nanofibres. This photothermal effect can be used to form asymmetric nanofibre films, to melt-blend polymer-polymer nanocomposites rapidly and to photo-pattern polymer nanofibre films.

Microscopy, Electron↗
PubMed2004

Nanostructured polyaniline sensors.

The conjugated polymer polyaniline is a promising material for sensors, since its conductivity is highly sensitive to chemical vapors. Nanofibers of polyaniline are found to have superior performance relative to conventional materials due to their much greater exposed surface area. A template-free chemical synthesis is described that produces uniform polyaniline nanofibers with diameters below 100 nm. The interfacial polymerization can be readily scaled to make gram quantities. Resistive-type sensors made from undoped or doped polyaniline nanofibers outperform conventional polyaniline on exposure to acid or base vapors, respectively. The nanofibers show essentially no thickness dependence to their sensitivity.

Journal Article↗
PubMed2004

A general chemical route to polyaniline nanofibers.

Uniform polyaniline nanofibers readily form using interfacial polymerization without the need for templates or functional dopants. The average diameter of the nanofibers can be tuned from 30 nm using hydrochloric acid to 120 nm using perchloric acid as observed via both scanning and transmission electron microscopy. When camphorsulfonic acid is employed, 50 nm average diameter fibers form. The measured Brunauer-Emmett-Teller surface area of the nanofibers increases as the average diameter decreases. Further characterization including molecular weight, optical spectroscopy, and electrical conductivity are presented. Interfacial polymerization is shown to be readily scalable to produce bulk quantities of nanofibers.

Journal Article↗
PubMed2004

Polyelectrolyte-mediated assembly of copper-phthalocyanine tetrasulfonate multilayers and the subsequent production of nanoparticulate copper oxide thin films.

An approach to producing films of nanometer-sized copper oxide particulates, based on polyelectrolyte-mediated assembly of the precursor, copper(II)phthalocyanine tetrasulfonate (CPTS), is described. Multilayered CPTS and polydiallyldimethylammonium chloride (PDADMAC) were alternately assembled on different planar substrates via the layer-by-layer (LbL) procedure. The growth of CPTS multilayers was monitored by UV-visible spectrometry and quartz crystal microbalance (QCM) measurements. Both the UV-visible spectra and the QCM data showed that a fixed amount of CPTS could be attached to the substrate surface for a given adsorption cycle. Cyclic voltammograms at the CPTS/PDADMAC-covered gold electrode exhibited a decrease in peak currents with the layer number, indicating that the permeability of CPTS multilayers on the electrodes had diminished. When these CPTS multilayered films were calcined at elevated temperatures, uniform thin films composed of nanoparticulate copper oxide could be produced. Ellipsometry showed that the thickness of copper oxide nanoparticulate films could be precisely tailored by varying the thickness of CPTS multilayer films. The morphology and roughness of CPTS multilayer and copper oxide thin films were characterized by atomic force microscopy. X-ray diffraction (XRD) measurements indicated that these thin films contained both CuO and Cu2O nanoparticles. The preparation of such copper oxide thin films with the use of metal complex precursors represents a new route for the synthesis of inorganic oxide films with a controlled thickness.

Adsorption↗
PubMed2003

Polyaniline nanofibers: facile synthesis and chemical sensors.

Polyaniline nanofibers with uniform diameters between 30 and 50 nm can be made in bulk quantities through a facile aqueous/organic interfacial polymerization method at ambient conditions. The nanofibers have lengths varying from 500 nm to several micrometers and form interconnected networks. Thin films made of the nanofibers have superior performance in both sensitivity and time response to vapors of acid (HCl) and base (NH3).

Journal Article↗
PubMed2001

Ultrasound-Induced Formation of CdS Nanostructures in Oil-in-Water Microemulsions.

In this study the formation of approximately spherical assemblies of nanocrystalline primary particles of CdS in a CS(2)-water-ethylenediamine (CWE) microemulsion induced by ultrasonic irradiation is described. CS(2) was employed as the sulfur source for CdS and also as the oil phase in the microemulsion. The particles were studied with X-ray powder diffraction, transmission electron microscopy, UV/Vis absorption spectroscopy, and photoluminescence spectroscopy. A blue shift compared to bulk CdS was observed in absorption and photoluminescence spectra. Copyright 2001 Academic Press.

Journal Article↗