Biomedical subjects

Jin Seo Park

Publications and source records attributed to Jin Seo Park.

8 recordsLinked to original sources

PubMed2006

Three-dimensional reconstruction of urogenital tract from Visible Korean Human.

The three-dimensional (3D) modeling from anatomical images is revealed to be a remarkable learning tool in anatomy. This is particularly true for the pelvis area and the urogenital tract. The authors present here a 3D reconstruction of the male urogenital tract from the Visible Korean Human data. The segmentation of 440 anatomical images was arranged in a pile and processed by the SURFdriver software to build an interactive 3D model. Forty-two anatomical structures were reconstructed, including kidneys, ureters, urinary bladder (outer and inner boundaries), urethra, testes, epididymides, ducti deferens, seminal vesicles, prostate, rectum, anal canal, abdominal aorta, superior mesenteric artery, renal arteries, inferior vena cava, renal veins, lumbar vertebrae, intervertebral discs, sacrum, hip bones, femurs, and skin. Three-dimensional models of 42 anatomical structures can be individually and interactively manipulated. In addition, the use is able to control the transparency of the model. The aim of this computerized modeling is to present a learning tool for students and patients. In the near future, it could be the basis of new simulation tools for surgeon's training.

Asian People↗

PubMed2006

Method for preparing permanent brain slices and serial slice images for education and MRI correlation.

It is important to understand the anatomical structures of the human brain in horizontal planes. Serially sectioned brain slices can easily be made with a meat slicer. The objective of this research was to enhance the educational value of serial brain slices made with a meat slicer through various applications. Two brains were taken out of two cadavers and embedded with gelatin solution to make two brain blocks. The first brain block was serially sectioned at 5 mm thickness using a meat slicer to make 28 horizontal brain slices. Each brain slice was embedded with a synthetic resin mixture to make 28 permanent specimens. The second brain block was magnetic resonance-scanned at 1.4 mm thickness to make 130 horizontal magnetic resonance images, then serially sectioned at the same thickness using the meat slicer to make 130 horizontal brain slices. Each brain slice was scanned into a computer to make a series of slice images. Ten anatomical structures in the slice images were outlined to make segmented images. Corresponding magnetic resonance images, slice images, and segmented images were stacked and volume-reconstructed to make three-dimensional images, which were sectioned and rotated at free angles. We show that the serial brain slices made with a meat slicer can be permanently preserved and used in a variety of educational settings. Anat Rec (Part B: New Anat) 289B:64-71, 2006. (c) 2006 Wiley-Liss, Inc.

Brain↗

PubMed2006

Visible Korean Human: its techniques and applications.

Three recent studies have offered an unprecedented view of the human body. The Visible Human Project, the Visible Korean Human (VKH), and the Chinese Visible Human have featured the serial sectioning of whole cadavers, producing cross-sectional images that methodically catalogue gross human anatomy. By volumetric reconstruction, these cross-sectional images can be transformed into three-dimensional (3D) images of anatomic structures. Compiling these 3D images would create an invaluable library for medical education and research. The goal of this report is to promote the expansion of such a library of 3D anatomic images and to help users fully understand and utilize the serially sectioned images. To do this, we will discuss the fundamental techniques and equipment used in the VKH and its preliminary experiments. We will also address new applications of the VKH, including virtual brain surgery, virtual endoscopy, and virtual cardiopulmonary resuscitation via the development of virtual dissection software.

Anatomy↗

PubMed2005

Technical report on semiautomatic segmentation using the Adobe Photoshop.

The purpose of this research is to enable users to semiautomatically segment the anatomical structures in magnetic resonance images (MRIs), computerized tomographs (CTs), and other medical images on a personal computer. The segmented images are used for making 3D images, which are helpful to medical education and research. To achieve this purpose, the following trials were performed. The entire body of a volunteer was scanned to make 557 MRIs. On Adobe Photoshop, contours of 19 anatomical structures in the MRIs were semiautomatically drawn using MAGNETIC LASSO TOOL and manually corrected using either LASSO TOOL or DIRECT SELECTION TOOL to make 557 segmented images. In a similar manner, 13 anatomical structures in 8,590 anatomical images were segmented. Proper segmentation was verified by making 3D images from the segmented images. Semiautomatic segmentation using Adobe Photoshop is expected to be widely used for segmentation of anatomical structures in various medical images.

Anatomy, Cross-Sectional↗

PubMed2005

Visible Korean human: improved serially sectioned images of the entire body.

The data from the Visible Human Project (VHP) and the Chinese Visible Human (CVH), which are the serially sectioned images of the entire cadaver, are being used to produce three-dimensional (3-D) images and software. The purpose of our research, the Visible Korean Human (VKH), is to produce an enhanced version of the serially sectioned images of an entire cadaver that can be used to upgrade the 3-D images and software. These improvements are achieved without drastically changing the methods developed for the VHP and CVH; thus, a complementary solution was found. A Korean male cadaver was chosen without anything perfused into the cadaver; the entire body was magnetic resonance (MR) and computed tomography (CT) scanned at 1.0-mm intervals to produce MR and CT images. After scanning, entire body of the cadaver was embedded and serially sectioned at 0.2-mm intervals; each sectioned surface was inputted into a personal computer to produce anatomical images (pixel size: 0.2 mm) without any missing images. Eleven anatomical organs in the anatomical images were segmented to produce segmented images. The anatomical and segmented images were stacked and reconstructed to produce 3-D images. The VKH is an ongoing research; we will produce a female version of the VKH and provide more detailed segmented images. The data from the VHP, CVH, and VKH will provide valuable resources to the medical image library of 3-D images and software in the field of medical education and clinical trials.

Adult↗

PubMed2005

Hypoadiponectinemia and insulin resistance are associated with nonalcoholic fatty liver disease.

We investigated the association between nonalcoholic fatty liver disease (NAFLD) and plasma adiponectin levels and insulin resistance. We recruited study subjects among one hundred and eighty one persons who were examined abdominal ultrasound at routine screening tests. A standard interview (consumption of alcohol and medical history), physical examination (height, weight, waist circumference, and blood pressure), and biochemical study (lipid parameters, aminotransferases, fasting plasma glucose, fasting insulin, and plasma adiponectin) were performed. Subjects who consumed alcohol more than moderate, evidence of viral hepatitis, toxic hepatitis, and serious cardiac, renal, or hepatic disease were excluded. Thirty-eight NAFLD patients and 53 control subjects diagnosed by ultrasound were finally analyzed. The plasma adiponectin level was significantly correlated with HDL-cholesterol (r=0. 38, p<0.001), triglycerides (r=-0.22, p=0.04), fasting insulin (r=-0.37, p<0.01), and insulin resistance by homeostasis model of assessment-insulin resistance (HOMAIR) (r=-0.39, p<0.01), after adjusting for age, sex, and adiposity. Multiple logistic regression analysis indicated that HOMA-IR was a significant predictor of having NAFLD (odds ratio [OR]=2.38; 95% confidence interval [CI]: 1.52-5.74), while adiponectin had a protective effect against NAFLD (OR=0.22; 95% CI: 0.09-0.55). We demonstrated that hypoadiponectinemia and insulin resistance are associated with NAFLD independent of obesity.

Adiponectin↗

PubMed2004

Dissemination of transferable AmpC-type beta-lactamase (CMY-10) in a Korean hospital.

To determine dissemination and genotype of AmpC beta-lactamases and an extended-spectrum beta-lactamase among clinical isolates of Enterobacteriaceae, we performed antibiotic susceptibility testing, pI determination, induction test, plasmid profiles, transconjugation test, enterobacterial repetitive consensus (ERIC)-PCR, and DNA sequencing. Among the 51 clinical isolates collected from a university hospital in Korea, six isolates were resistant to cephamycins. All six isolates produced a plasmid-encoded AmpC-type beta-lactamase, CMY-10. Five strains also produced one or more other beta-lactamases: SHV-12, an extended-spectrum beta-lactamase (five isolates); TEM-1, a class A beta-lactamase (two isolates); and a chromosomal AmpC beta-lactamase (one isolate, a strain of Enterobacter aerogenes, which produced all four of the beta-lactamases that were identified). One of six isolates produced only CMY-10. ERIC-PCR analysis revealed that dissemination of CMY-10 and SHV-12 was due to a clonal outbreak of a resistant strain and to the interspecies spread of resistance to cephamycins and broad-spectrum beta-lactams in Korea. CMY-10 beta-lactamase genes that are responsible for the resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin, and amoxicillin-clavulanic acid were cloned and characterized from six clinical isolates. A sequence identical to the common regions in In6, In7, and a novel integron from pSAL-1 was found upstream from blaCMY-10 gene at nucleotides 1-71. A total of 15 nucleotides (I-15) or 18 nucleotides (I-18) between position 71 and 72 were inserted into the blaCMY-10 gene. The blaCMY-10 gene might be inserted into a sul1-type complex integron by I-15 or I-18.

Amino Acid Sequence↗

PubMed2002

Visible Korean Human: another trial for making serially-sectioned images.

In this ongoing study, we are trying to make Visible Korean Human (Mar 2000--Feb 2005). The complete MRIs and CTs of the Korean cadaver's entire body are scanned. The cadaver is serially-sectioned at 0.2 mm thickness without any missing images. The anatomical structures in the sectioned images are segmented. The Visible Korean Human is expected to be more helpful than Visible Human in the following ways. First, the Korean data will be more helpful in diagnosing and treating the patients belonging to the yellow race. Second, MRIs and CTs of the entire body at 1 mm thickness will be more helpful in studying the MRIs and CTs. Third, sectioned images without any missing images will be more helpful in making the complete 3D images. Fifth, small pixel size (0.2 mm x 0.2 mm) and thin thickness (0.2 mm) of sectioned images will be more helpful in showing the small anatomical structures greater than 0.2 mm. Sixth, the additional segmented images will be more helpful in making the 3D image and virtual dissection software. The Visible Korean Human will be the basis for making better 3D image and virtual dissection software which will be more helpful in medical education.

Adult↗