Biomedical subjects

Jin-Young Min

Publications and source records attributed to Jin-Young Min.

5 recordsLinked to original sources

PubMed2007

Influence of upper airway narrowing on the effective continuous positive airway pressure level.

BACKGROUND AND OBJECTIVES: The aim of this study was to determine the relationship between the continuous positive airway pressure (CPAP) titration level and upper airway variables in obstructive sleep apnea syndrome (OSAS). SUBJECTS AND METHODS: Forty-seven patients suffering from OSAS were enrolled in this study. They were asked to answer a questionnaire about nasal stuffiness and mouth breathing, and the degree of tonsillar hypertrophy and shape of the oropharyngeal inlet were evaluated. The minimal cross-sectional area (MCA) of the nasal cavity was measured with acoustic rhinometry, followed by optimal CPAP level titration. We compared optimal CPAP levels with body mass index (BMI), perceived nasal stuffiness, and anatomic upper airway narrowing. RESULTS: The mean CPAP level was 6.32 +/- 2.17 cm H2O. We found a significant correlation between CPAP levels and BMI (P = .01), apnea-hypopnea index (P = .015), and the degree of tonsillar hypertrophy (P = .011). Furthermore, the CPAP level increased significantly with the MCA on the narrow side of the nasal cavity (P = .038) in patients with a BMI less than 25. Other variables, such as subjective symptoms and anatomic nasal airway occlusion in obese patients (BMI > or = 25), revealed no correlation with the CPAP level. CONCLUSIONS: Upper airway occlusion including nasal obstruction or tonsillar hypertrophy might increase the effective CPAP level.

Adult↗

PubMed2006

The association between neurobehavioral performance and lung function.

This study investigated the relationship between neurobehavioral performance and pulmonary function in young and middle adults. Data were collected from 178 subjects (88 male, 90 female) aged 20-50 years. Neurobehavioral performance was assessed by the Korean version of The Swedish Performance Evaluation System (SPES-K), on five items: simple reaction time, symbol digit, digit span, and finger tapping speed for dominant and non-dominant hands. Pulmonary function, as indicated by the 1-s forced expiratory volume (FEV1), was measured according to American Thoracic Society criteria and the potential association was analyzed by linear regression. For simple reaction time, symbol digit, and digit span, the performance of subjects with FEV1 levels exceeding 3.29 l was 2-4% greater than those with the lowest levels of less than 2.60 l, after controlling for the effects of age, sex, education, smoking, and height. Finger tapping speed, however, did not show any significant association. These findings suggest that pulmonary function may influence neurobehavioral performance, especially cognitive abilities, throughout adulthood.

Adult↗

PubMed2006

Neurobehavioral function in children with low blood lead concentrations.

Debate continues as to whether low blood lead level, even below 5 microg/dl, impairs neurodevelopmental function in children. This study assessed the association between neurodevelopmental performance and lead exposure below 5 microg/dl in Korean children. Data were collected from 61 children, aged 7-16 years with a mean blood lead level of 2.9 microg/dl, who participated with their mothers. Neurodevelopmental function was measured with computer-based neurobehavioral tests. The analyzed data included children's performances on five neurobehavioral tests as the dependent variables, and children's blood lead level, sex, age, and mother's performance as the four independent variables. For simple reaction time and digit span, which, respectively reflect attention and short-term memory, there was a small and significant association between the children's neurodevelopmental performance and their blood lead levels (p=0.05, 0.08, respectively). Our study suggests that low blood lead below 5 microg/dl can influence children's neurobehavioral performance.

Adolescent↗

PubMed2006

Effects of staphylococcal enterotoxin on ciliary activity and histology of the sinus mucosa.

CONCLUSION: The results of our study suggest that Staphylococcus aureus enterotoxin A (SEA) may play an important role in the pathogenesis of rhinosinusitis by ciliostatic effects at high concentrations, and by a different mechanism at low concentrations. OBJECTIVES: To investigate the in vitro effects of SEA on ciliary activity and its in vivo effects on histology of the sinus mucosa. MATERIALS AND METHODS: The in vitro effects of SEA on ciliary activity at different concentrations and exposure time were investigated using maxillary sinus mucosa harvested from experimental rabbits. After in vivo instillation of different concentrations (high and low dose) of SEA into the maxillary sinus, ciliary beat frequency (CBF) and histologic findings of the maxillary sinus mucosa were examined. RESULTS: After exposure to low doses of SEA (0.03 and 0.3 ng/ml), CBF did not decrease, but after exposure to high doses of SEA (1.5, 3, and 30 ng/ml), CBF decreased significantly as a function of time. At 24 h after instillation of high-dose SEA (30 ng/ml) into the sinus, CBF decreased significantly and rhinosinusitis was induced after 7 days. Although no alteration was observed in the CBF of the sinus mucosa after instillation of low-dose SEA (0.3 ng/ml), histological findings of rhinosinusitis including subepithelial edema and inflammatory cell infiltration were observed.

Animals↗

PubMed2006

Sentinel lymph node radiolocalization with 99mTc filtered tin colloid in clinically node-negative squamous cell carcinomas of the oral cavity.

The objective of this study was to evaluate the feasibility of sentinel lymph node biopsy by using a radiotracer lymphatic mapping technique in patients with squamous cell carcinoma of the oral cavity, and the diagnostic value of this technique. We studied twenty patients with previously untreated squamous cell carcinomas of the oral cavity and N0 necks. After the peritumoral injection of 99mTc filtered tin colloid preoperatively, lymphoscintigraphy and intraoperative mapping using a gamma detector were performed to localize sentinel nodes. An open biopsy of the sentinel node was followed by complete neck dissection. We identified the sentinel nodes in 19 of 20 patients (95.0%) by lymphoscintigraphy and in all (100%) by intraoperative gamma detector. In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%. The negative predictive value for the absence of cervical metastases was 100%. In conclusion, our radiolocalization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.

Adult↗