[Inhibition of the replication of hepatitis B virus in vitro by a novel nucleoside analogue (beta-L-D4A)].
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Antiviral Agents↗
Biomedical subjects
Jin-yan Zhang
Publications and source records attributed to Jin-yan Zhang.
[Therapeutic effect of secretive endostatin eukaryotic expressing plasmid on mouse hepatoma].
OBJECTIVE: To construct and express secretive endostatin eukaryotic plasmid for treatment of hepatoma. METHODS: Mouse Igk signal peptide sequence was synthesized and cloned into pcDNA3.1 with endostatin gene. The supernant of BHK-21 transfected with recombinant was used to culture ECV304. The proliferation of latter was evaluated by MTT assay. H22 was inoculated intramusclely, then naked DNA of endostatin plasmid was injected into the inoculation site. Tumors were dissected and weighted after treatments. All data was analyzed by SPSS10.0. RESULTS: The supernant of BHK-21 transfected with recombinant can inhibit the proliferation of ECV304 by 29.2%. Tumor weight lighter after injected with naked pSecES (1.34 g+/-0.96g) compared with naked pcDNA3.1 (2.70g+/-0.82g) and saline (3.73g+/-1.41g). CONCLUSION: The endostatin eukaryotic plasmid was constructed and it can be used for gene therapy on hepatoma.
Animals↗
[The design and implementation of DICOM Server Mediate Layer].
A DICOM Server Mediate Layer is introduced in this paper. It communicates with modalities according to DICOM3.0 standard on the one hand, provides a simple way to interface with other application on the other hand, this mades the implementation of DICOM service much easier for other applications.
Computer Communication Networks↗