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Jinghe Lang

Publications and source records attributed to Jinghe Lang.

At least 19 recordsLinked to original sources
PubMed2007

Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.

In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a sensitivity of 87.5% and a specificity of 80% in the diagnosis of endometriosis.

Adult↗
PubMed2005

Abdominal wall endometriomas.

OBJECTIVE: To investigate the clinical characteristics, treatment, and factors of recurrence of abdominal wall endometriomas (AWE). METHOD: Sixty-four cases of AWE diagnosed at Peking Union Medical College Hospital (PUMCH) from 1983 to 2003 were reviewed retrospectively. RESULT: There was an AWE incidence of 0.044% among the parturients undergoing cesarean section at PUMCH, of whom 87.5% had the typical complaint of an enlarging mass and pain during menstruation. Among these women, 62 underwent low abdominal surgery for endometrioma (2 for primary umbilicus endometrioma); 2 women with small endometriomas opted for a temporary medical solution and had relief after menopause. The latent period of AWE positively correlated to the women's age at onset of symptoms (P<0.001). Of the 62 women who underwent local excision, 19 had an unsatisfactory experience with medical management. There were 5 recurrences and 1 evolution to malignancy during a mean follow-up of 83.7 months. Recurrence was closely related to the size and depth of lesions. CONCLUSION: Because of its typical clinical manifestations, abdominal wall endometriomas could be diagnosed before pregnancy. Surgical excision is the only effective treatment and wide local excision with clear margins is the key point to prevent recurrence.

Abdominal Wall↗
PubMed2004

Estrogen receptor in pelvic floor tissues in patients with stress urinary incontinence.

Our study is to investigate the presence of estrogen receptor (ER) and its possible etiological relationship with the development of stress urinary incontinence (SUI). Thirty-one biopsy specimens from pelvic floor tissues were obtained from 31 patients categorized into three groups: pelvic organ prolapse (POP), SUI and control groups. ER in the pelvic muscles tissues was evaluated quantitatively after immunohistochemical staining to visualize the ER in the tissue. The sampling rate of levator ani (striated) muscle was 6.7% in total sample from the pelvic floor tissues, with the remaining showing connective tissues, smooth muscles and nerve fibers. ER positive staining was found in the in the nuclei of connective tissue, smooth muscles and nerve fibers. The positive rates of ER staining in tissues were 1.4%, 4.7% and 5.7%, respectively in control group versus 1.1%, 2.8% and 2.7% in SUI group and 4.1%, 9.5% and 11.6% in POP group. The positive rates of ER staining in connective tissue, smooth muscle and nerve fibers in SUI group were significantly lower than that in control and POP group (P<0.01). Our study suggests that a decrease of ER in the pelvic floor tissues might be related to the occurrence of SUI and implies that hormone replacement therapy might not be effective in treatment for SUI.

Case-Control Studies↗
PubMed2004

Vaginal hysterectomy for patients with moderately enlarged uterus of benign lesions.

OBJECTIVE: To evaluate the possibility of vaginal hysterectomy for patients with moderately enlarged uterus of benign lesions. METHODS: One hundred and seventeen women with benign uterine diseases underwent vaginal hysterectomy. These patients were divided into two groups according to uterine weight. Group I contained 60 patients with uterine enlargement to a weight of 200 to 750 g, and group II contained 57 patients with uterine weight of less than 200 g. Uterine morcellation was performed in some cases. The perioperative data in both groups were analyzed. RESULTS: In group I, 59 cases underwent transvaginal hysterectomy successfully, except 1 case converted to abdominal operation and the uterine morcellation was performed in 21 women. In group II, all patients successfully underwent transvaginal hysterectomy without any assistance of special technique. The mean uterine weight of group I was significantly heavier than that of group II (280.18 +/- 100.40 g vs 146.48 +/- 35.19 g). The mean operating time was significantly longer for group I than that for group II (83.93 +/- 26.26 minutes vs 35.22 +/- 20.55 minutes). There were no significant differences in blood loss and complications between group I and group II. There was no injury of urinary bladder or rectum, and no vaginal vault infection. CONCLUSIONS: Vaginal hysterectomy of moderately enlarged uterus can be safely and effectively performed by experienced operators. In some cases, in order to reduce the uterine volume, uterine morcellation should be used to shorten operative time, reduce the bleeding, and lower the postoperative complications.

Female↗
PubMed2003

A risk of malignancy index in preoperative diagnosis of ovarian cancer.

OBJECTIVE: To evaluate the ability of a risk of malignancy index (RMI), based on serum CA125 level, ultrasound findings and menopausal status, to discriminate benign from malignant pelvic mass. METHODS: One hundred and forty women with pelvic masses, at age 30 of years or more were admitted to the Peking Union Medical College Hospital between January 1998 and June 1999. The sensitivity, specificity and positive predictive value of serum CA125 level, ultrasound findings and the menopausal status in diagnosis of ovarian cancer were evaluated separately or combined into the RMI. RESULTS: RMI was more accurate than any individual criterion in diagnosing cancer. Using an RMI cutoff level of 200 to indicate malignancy, the RMI derived from this data set gave a sensitivity of 87.3%, a specificity of 84.4%, and a positive predictive value of 82.1%. CONCLUSIONS: RMI is able to correctly discriminate malignant from benign pelvic mass. It can be introduced easily into clinical practice to facilitate the selection of patients for primary surgery.

CA-125 Antigen↗
PubMed2003

Lower uterine segment pregnancy with placenta increta complicating first trimester induced abortion: diagnosis and conservative management.

OBJECTIVE: To discuss the diagnosis of and conservative management for lower uterine segment pregnancy with placenta increta complicating first trimester abortion. METHODS: Four patients with previous caesarean section and severe hemorrhage in induced abortion in the first trimester were studied. Uterine artery embolization (UAE) was used to control bleeding and preserve the uterus. RESULTS: UAE controlled heavy uterine bleeding satisfactorily. One of the four patients asked for a hysterectomy after UAE, and her pathology report confirmed "lower uterine segment pregnancy with placenta increta". CONCLUSION: Previous caesarean section is a risk factor for lower uterine segment pregnancy with placenta increta. UAE is one of the best conservative management methods for heavy hemorrhage, especially for women who desire future fertility.

Abortion, Induced↗
PubMed2003

Endometriosis in adolescents--analysis of 6 cases.

OBJECTIVE: To study the characteristics, diagnosis and treatment of endometriosis in adolescent patients. METHOD: Six cases of adolescent endometriosis in our hospital were reviewed retrospectively. RESULT: Endometriosis is the most common cause of chronic pelvic pain in adolescents. There may be a natural progression of endometriosis from atypical lesions in adolescents to classic lesions in adults. Congenital abnormalities of the reproductive tract are the main reasons for the adolescent endometriosis. CONCLUSION: Endometriosis should be strongly suspected in adolescent girls with chronic pelvic pain, especially unresponsive to oral contraceptives and nonsteroidal anti-inflammatory drugs. The treatment involves the operations and medicines.

Adolescent↗
PubMed2002

[Gynecology].

Explore the source record for details and available documents.

Biomedical Research↗
PubMed2002

[Role of positron emission tomography in detecting recurrent epithelial ovarian carcinoma].

OBJECTIVE: To investigate the efficiency of positron emission tomography (PET) with (fluorine-18)-2-deoxyglucose ((18)FDG) for detecting recurrent epithelial ovarian carcinoma. METHODS: Fifteen (18)FDG-PET scanning were performed on 13 patients, who was clinically free of disease after optimal cytoreductive surgery and sufficient chemotherapy, with suspicion of recurrence. Ten second-look or re-debulking operation were given after PET scanning. RESULTS: In all 8 cases with and 1 without elevated serum CA(125), PET demonstrated sites of increased (18)FDG uptake, which correlated well with surgical-pathologic findings (100%). Computed tomography scan and B ultrasonography each detected 1 recurrence. One of the 6 patients with negative PET scan results underwent a second-look operation, which found no malignancy. The other 5 were closely followed up for 11 to 13 months. No sign of recurrence was noticed within 8 months. One patient received her second PET scanning after the serum CA(125) began to elevate in the 9th month. Recurrent tumor was found by the second PET scan and confirmed by the operation after that. CONCLUSIONS: PET is accurate in detecting the recurrent epithelial ovarian carcinoma. As a non-invasive method, PET might be a fairly effective tool for monitoring and locating the recurrence of ovarian carcinoma.

CA-125 Antigen↗
PubMed2002

[Serum levels of soluble intercellular molecule 1 (sICAM-1) in endometriosis].

OBJECTIVE: To investigate the serum levels of ICAM-1 and its relationship to the extent of the disease. METHODS: Serum sICAM-1 levels of 21 women with endometriosis were measured with a specific enzyme-linked immunosorbent assay, and 21 women without endometriosis were selected as control. Serum sICAM-1 levels were compared between endometriotic and non-endometriotic women, and among patients at different stages of endometriosis. RESULTS: Significantly higher serum sICAM-1 levels were observed in women with endometriosis [(0.30 +/- 0.07) microgram/ml] than in those without endometriosis [(0.18 +/- 0.05) microgram/ml] (P < 0.01); in women with stage I approximately II of endometriosis, the serum sICAM-1 levels were (0.24 +/- 0.06) microgram/ml, while in those with stage III approximately IV of endometriosis, the serum sICAM-1 level was (0.32 +/- 0.06) microgram/ml, the difference is of statistically significant.No differences of serum sICAM-1 level was found between proliferative and secretary phase in women with and without endometriosis. CONCLUSIONS: Significantly elevated serum sICAM-1 levels in women with endometriosis, especially in those with advanced stages of the disease suggests the molecule might be of value in pathogenesis of endometriosis.

Adult↗
PubMed2002

[Clinical analysis of 11 cases with perineal endometriosis].

OBJECTIVE: To report the diagnosis and treatment of 11 cases with perineal endometriosis (PE). METHODS: Eleven patients with PE treated in our department from 1983 - 2000 years were analyzed retrospectively and were followed for 0.5 - 7.0 years. RESULTS: The incidence of PE is 0.37% of total endometriosis cases operated in our department or 0.087 per thousand of total episiotomy undergone in our delivery room during the 18 year period. Their diagnosis were confirmed clinical manifestations and pathological evidences. All except one had history of perineal tear and episiotomy. The latent period of patient who was less than 30 years old is within one year. The latent period of patient who was more than 30 years old is more than one years (P < 0.05). Complete surgical excision with a cure rate of 91% (10/11). CONCLUSIONS: PE is mainly diagnosed by clinical manifestations. Surgical excision is the first choice of treatment.

Adult↗
PubMed2002

[Influence of surgical methods on survival and recurrence of stage I endometrial carcinoma].

OBJECTIVE: To determine the influence of different surgical procedure on post-operative survival rate and recurrence of stage I endometrial carcinoma. METHODS: From 1986 to 1996, 110 patients with stage I endometrial carcinoma surgically treated in our hospital were studied retrospectively. They were divided into three groups, including total hysterectomy plus bilateral salpingo-oophorectomy (group A), radical or modified radical hysterectomy (group B) and total hysterectomy plus bilateral salpingo-oophorectomy or radical hysterectomy or modified radical hysterectomy + pelvic lymphadenectomy (group C). Survival and recurrent rates were analysed according to the follow-up data. RESULTS: Five-year survival rate of the three groups are 89.5%, 90.5% and 95.1% respectively (P > 0.05). Of the 71 cases followed up for more than two years, 9 relapsed. The recurrent rates were 12.7%. Seven relapsed within three years after operation. Eight patients had local recurrence and 5 had distant metastasis. Recurrent rates of three groups are 13.9%, 9.1% and 12.5% (P > 0.05), local recurrent rates are 13.9%, 9.1% and 8.3% (P > 0.05), distant metastasis rates are 2.8%, 9.1% and 12.5% respectively (P > 0.05) with no statistical significance. CONCLUSIONS: Surgical method is not the main factor influenced the survive of stage I endometrial carcinoma. Radical operation or lymphadenectomy will not increase the survival rate of stage I endometrial carcinoma significantly. The purpose of such operation is to find out the exact stage and the possible prognosis. Distant metastasis is remarkable, and should be considered in the adjuvant therapy.

Adult↗
PubMed2002

[Systematic evaluation of the new screen methods of cervical intraepithelial neoplasm].

OBJECTIVE: To evaluate new cytologic screening methods of papnet cytology computer technology (CCT) and thinprep pap test (TPT) on cervical intraepithelial neoplasm (CIN). METHODS: Three hundred and seventy four cases with abnormal cervical cytologic results received colposcopic examinations and multiple biopsies. The results of cytologic screening compared with the results of histologic-colposcopic diagnosis were analysed retrospectively. RESULTS: A total of 374 cases were diagnosed by cytology, 9.1% with inflammations, 43.3% with low grade squamous intraepithelial lesion (LSIL) and 20.3% with high grade squamous intraepithelial lesion (HSIL) and 1.9% suspected with squamous cell carcinoma. However, after examination by colposcopy and multiple biopsies, the situation was different. The percentage of cases with inflammation increased to 53.5%, cervical intraepithelial neoplasm I (CIN I) decreased to 17.9%, CIN II and CIN III and cervical carcinoma in situ (CIS) elevated to 25.4% and invasive squamous cell carcinoma increased to 3.2%. Among cases with atypical squamous cell of undetermined significance (ASCUS), 52.6% (50/95) were with inflammations or negative results, 47.4% (45/95) with CIN I or even greater. Among 374 cases, 188 women were screened by CCT and 186 by TPT. When all cytological findings compared with the histologic-colposcopic results, respectively, the coincidence of TPT with histologic-colposcopic results was significantly higher than that of CCT (P < 0.01). The coincidence rate (79.7%) of screening cases with LSIL or inflammation was significantly higher than that (20.3%) of cases with HSIL or even greater (P < 0.01). But there was no difference between two methods. The incidence of human papillomaviral infection (HPV) infection at colposcopies was 34.0%. The high incidences of HPV and CIN infection were found among women from 20 to 30 years old and from 30 to 50 years old, respectively. CONCLUSIONS: Cases with abnormal cytologic findings should undergo colpscopic examination and multiple biopsies for further diagnosis. Only in this way, cases with CIN or HPV infection could not be misdiagnosed. Women ranged from 30 - 50 years old should receive cytologic screening or colposcopic examination regularly.

Adult↗
PubMed2002

[Clinical characteristics of clear cell carcinoma of the ovary].

OBJECTIVE: To study the clinical characteristics of clear cell carcinoma of the ovary. METHODS: Forty three patients with clear cell carcinoma of the ovary and 51 patients with serous adenocarcinoma of the ovary who were admitted in Peking Union Medical College Hospital between 1984 to 2000 were analyzed retrospectively, and their chemosensitivities and the survival rates were compared. RESULTS: The percentage of early stage patients in the clear cell carcinoma of the ovary and the serous adenocarcinoma of the ovary was 14.4% and 3.8% respectively, the difference was significant (P < 0.005). In the late stage patients who underwent satisfactory cytoreductive surgery, the chemo-resistant rate (88.9%) in the clear cell carcinoma of the ovary was significantly higher than that (57.1%) of the serous adenocarcinoma of the ovary (P < 0.02), the 1-year survival rate (79.0%) in the clear cell carcinoma of the ovary was significantly lower than that (96.2%) of the serous adenocarcinoma of the ovary (P < 0.01). In the late stage patients who underwent unsatisfactory cytoreductive surgery, the chemo-resistant rate and the survival rate had no significant difference between the clear cell carcinoma of the ovary and the serous adenocarcinoma of the ovary (P > 0.05). CONCLUSIONS: There are more early stage patients with clear cell carcinoma of the ovary. We should conduct auxiliary therapy and close follow up to them after surgery. Clear cell carcinoma of the ovary is chemo-resistant to platinum-based chemotherapy and has poor prognosis.

Adenocarcinoma, Clear Cell↗
PubMed2002

[Congenital vaginal atresia: report of 16 cases].

OBJECTIVE: To analyze the clinical features of congenital vaginal atresia (CVA) with normal uterine corpus and investigate the relationship between the subtypes and management. METHODS: Sixteen cases, partical atresia (type I) 10 and complete atresia (type II) 6, treated in Peking Union Medical College Hospital, during the past 16 years, were analysed retrospectively. RESULTS: Patients with type I CVA had an earlier onset of symptoms [(13.0 +/- 1.1) years of age], duration of [(3.5 +/- 2.4) months], greater pelvic masses [(7.7 +/- 3.0) cm in diameter] with lower location as compared with type II CVA [(15.5 +/- 3.4) years of age, 24.0 months, (5.3 +/- 1.0) cm in diameter, P < 0.01]. Distal colpoplasty was performed on 10 type I cases and vaginal mold was placed postoperatively. Dysmenorrhea relieved in all cases during median 21 month follow-up. Vaginal dilatation was done in 4 cases due to readhesion and constriction. One out of the 2 married patients delivered viable neonate by cesarean section. Three out of 6 type II patients were complicated with either endometriosis or hematosalpinx or double uterus. Hysterectomy with or without colpoplasty was done. While the other 3 underwent colpoplasty and cervical canalization. Only 2 had menses after operation, but 1 of the developed dysmenorrhea, ovarian endometrioma and was treated surgically again, the other 1 had hypomenorrhea. CONCLUSION: Patients with type I CVA had better outcomes after colpoplasty if they persist on placing vaginal mold. While for type II CVA, hysterectomy usually needed in most cases.

Adolescent↗
PubMed2002

[Study on chemotherapy-induced disorders of glucose metabolism in patients with malignant ovarian tumor].

OBJECTIVE: To determine the effect of chemotherapy on glucose metabolism in patients with malignant ovarian tumor. METHODS: The blood glucose assay and associated clinical materials of 375 cases with malignant ovarian tumor who received chemotherapy from January 1997 to December 2001 were analyzed retrospectively. RESULTS: Thirty-two cases (8.5%) had elevated fasting blood glucose after chemotherapy. Among them, 14 cases (3.7%) were diagnosed as diabetes mellitus, 9 cases (2.4%) were diagnosed as impaired glucose tolerance. Paclitaxel based chemotherapy seemed to have more opportunity to induce disorders of glucose metabolism than that in cisplatin based chemotherapy (P < 0.05), and this happened most frequently in 1 approximately 3 courses. CONCLUSION: Chemotherapy may induce disorders of glucose metabolism, which most frequently occurred in 1 approximately 3 courses, including impaired glucose tolerance or diabetes mellitus,especially in patients received paclitaxel chemotherapy.

Adult↗
PubMed2002

Clinical analysis of 4 cases of juvenile granulosa cell tumor of the ovary.

OBJECTIVE: To review the diagnosis, treatment and prognosis of juvenile granulosa cell tumor of the ovary (JGCT). METHODS: To review four patients with JGCT treated in Peking Union Medical College Hospital from 1983 to 2002. RESULTS: JGCT is rare and most of the patients are adolescent or children. Solid pelvic mass with ascites and pleural effusion were mainly clinical feature. The levels of estrogen of the four patients were normal. Diagnoses were made by pathology. All 4 patients were at stage I and treated with surgery and combined chemotherapy. Two patients with high mitotic index progressed and died after 10 and 14 months, and the others without high mitotic index obtained a complete remission for 25 and 32 months. CONCLUSIONS: The diagnosis of JGCT is made by pathology definitely. The prognosis is poor when patient has high mitotic index. Cytoreductive surgery is the treatment of choice and combination chemotherapy may be helpful to improve the prognosis of JGCT.

Adolescent↗