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Biomedical subjects

Jinhui Xu

Publications and source records attributed to Jinhui Xu.

7 recordsLinked to original sources

Towards a theory of a solution space for the biplane imaging geometry problem.

Biplane angiographic imaging is a primary method for visual and quantitative assessment of the vasculature. In order to reliably reconstruct the three-dimensional (3D) position, orientation, and shape of the vessel structure, a key problem is to determine the rotation matrix R and the translation vector t which relate the two coordinate systems. This so-called Imaging Geometry Determination problem is well studied in the medical imaging and computer vision communities and a number of interesting approaches have been reported. Each such technique determines a solution which yields 3D vasculature reconstructions with errors comparable to other techniques. From the literature, we see that different techniques with different optimization strategies yield reconstructions with equivalent errors. We have investigated this behavior, and it appears that the error in the input data leads to this equivalence effectively yielding what we call the solution space of feasible geometries, i.e., geometries which could be solutions given the error or uncertainty in the input image data. In this paper, we lay the theoretical framework for this concept of a solution space of feasible geometries using simple schematic constructions, deriving the underlying mathematical relationships, presenting implementation details, and discussing implications and applications of the proposed idea. Because the solution space of feasible geometries encompasses equivalent solutions given the input error, the solution space approach can be used to evaluate the precision of calculated geometries or 3D data based on known or estimated uncertainties in the input image data. We also use the solution space approach to calculate an imaging geometry, i.e., a solution.

Algorithms↗

When aerosol sulfate goes up, so does oxalate: implication for the formation mechanisms of oxalate.

Oxalic acid is often the single most abundant water-soluble organic compound identified in ambient aerosols, but its precursors have not been identified, and its formation mechanism is not well understood. On the contrary, sulfate as a major aerosol component, its formation pathways have been established, and in-cloud processing is recognized as its major production pathway. Our measurements of aerosol sulfate and oxalate collected across a wide geographical span in the East Asia region, up to Beijing in the north and down to Hong Kong in the south, indicate that the two species are highly correlated among samples collected at the same location and among samples collected at different locations in the Pearl River Delta region. This good correlation is also found in measurements made elsewhere by other researchers. We argue that a common dominant formation pathway, likely in-cloud processing, explains the close tracking of the two chemically distinct species. This also highlights the potential importance of in-cloud processing as a pathway leading to formation of secondary organic aerosols.

Aerosols↗

Motion tracking and intensity surface recovery in microscopic nuclear images.

Current techniques for microscopic imaging do not provide necessary spatial and temporal resolutions for real time visualization of the nucleus. Images can only be acquired in time lapse mode, leading to significant loss of information between image frames. Such data, if available, can be extremely helpful in the study of nuclear organization and function. In this paper, we present a gamut of geometric-technique-based approaches for solving the problem. Our techniques, working together, can effectively recover complicated motion and deformation as well as the change of intensity surfaces from pairs of images in a microscopic image sequence, and has low time complexity, particularly desirable by many biological applications where large amount of DNA need to be processed. These techniques are also readily applicable to other types of images for reconstructing motion and intensity surfaces of deformable objects.

Algorithms↗

Efficient Algorithms for Determining 3-D Bi-Plane Imaging Geometry.

Biplane projection imaging is one of the primary methods for imaging and visualizing the cardiovascular system in medicine. A key problem in such a technique is to determine the imaging geometry (i.e., the relative rotation and translation) of two projections so that the interested 3-D structures can be accurately reconstructed. Based on interesting observations and efficient geometric techniques, we present in this paper new algorithmic solutions for this problem. Comparing with existing optimization-based approaches, our techniques yield better accuracy, have bounded execution time, and thus are more suitable for on-line applications. Our techniques can easily detect outliers to further improve the accuracy.

Journal Article↗

Effects of point configuration on the accuracy in 3D reconstruction from biplane images.

Two or more angiograms are being used frequently in medical imaging to reconstruct locations in three-dimensional (3D) space, e.g., for reconstruction of 3D vascular trees, implanted electrodes, or patient positioning. A number of techniques have been proposed for this task. In this simulation study, we investigate the effect of the shape of the configuration of the points in 3D (the "cloud" of points) on reconstruction errors for one of these techniques developed in our laboratory. Five types of configurations (a ball, an elongated ellipsoid (cigar), flattened ball (pancake), flattened cigar, and a flattened ball with a single distant point) are used in the evaluations. For each shape, 100 random configurations were generated, with point coordinates chosen from Gaussian distributions having a covariance matrix corresponding to the desired shape. The 3D data were projected into the image planes using a known imaging geometry. Gaussian distributed errors were introduced in the x and y coordinates of these projected points. Gaussian distributed errors were also introduced into the gantry information used to calculate the initial imaging geometry. The imaging geometries and 3D positions were iteratively refined using the enhanced-Metz-Fencil technique. The image data were also used to evaluate the feasible R-t solution volume. The 3D errors between the calculated and true positions were determined. The effects of the shape of the configuration, the number of points, the initial geometry error, and the input image error were evaluated. The results for the number of points, initial geometry error, and image error are in agreement with previously reported results, i.e., increasing the number of points and reducing initial geometry and/or image error, improves the accuracy of the reconstructed data. The shape of the 3D configuration of points also affects the error of reconstructed 3D configuration; specifically, errors decrease as the "volume" of the 3D configuration increases, as would be intuitively expected, and shapes with larger spread, such as spherical shapes, yield more accurate reconstructions. These results are in agreement with an analysis of the solution volume of feasible geometries and could be used to guide selection of points for reconstruction of 3D configurations from two views.

Coronary Angiography↗

Steric effects on diffusion of associated molecules in acetone.

The effects due to steric hindrance on solute-solvent interactions and on diffusion of associated molecules were found by comparing the diffusion coefficients of different aromatic isomers in acetone at 298.2 K; there exists a correlation between the isomeric effects of intermolecular association on diffusion and the molecular scales of overall hydrogen-bond acidity of the isomers studied.

Acetone↗

Charring characteristics of atmospheric organic particulate matter in thermal analysis.

The charring of organic materials during carbon analysis bythermal methods makes it difficult to differentiate elemental carbon (EC) from organic carbon (OC). Failure to correct for charring results in the overestimation of EC and the underestimation of OC. The charring characteristics andthermal behaviors of aerosol OC are studied by subjecting hexane and water extracts of ambient aerosols to various analysis conditions. The complete evolution of water-soluble organic carbon (WSOC) aerosol materials is found to require a temperature as high as 850 degrees C and the presence of oxygen. EC would be oxidized under these thermal conditions as well. As a result, thermal methods relying only on temperature for the differentiation of EC and OC would give unreliable OC and EC concentrations. Our investigation also reveals that WSOC accounts for a large fraction (13-66%) of charring, while hexane extractable organic compounds produce little charring. The extent of charring from WSOC, defined as the ratio between pyrolytically generated EC to the total WSOC, is found to increase with the WSOC loading in each analysis when the loadings are below a certain value. This ratio remains constant when the loadings are above this value. This may account for the high variability in the extent of charring among aerosol samples from different locations as well as among samples from a single location collected at different times. Charring is reduced if the residence time at each temperature step in a helium atmosphere is sufficiently long to allow for maximum C evolution at each step. Charring is also influenced by the presence of inorganic constituents such as ammonium bisulfate. For the few tested organic materials, it is observed that ammonium bisulfate enhances the charring of starch and cellulose but reduces the charring of levoglucosan.

Aerosols↗