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Biomedical subjects

Jiquan Liu

Publications and source records attributed to Jiquan Liu.

3 recordsLinked to original sources

[Visualization of EIM simulation data on real cardiac model].

Although 3D heart and torso model with realistic geometry are the basis of simulation computation in LFX Virtual Cardiac Model, the simulation results are mostly output in 2D format. Voxel mapping method is presented to solve this problem and extend the function of LFX Virtual Cardiac Model. Excitation Isochrone Map (EIM), one of the most important simulation results, was mapped from cardiac model with realistic geometry to real Visible Man cardiac model, then the EIM simulation data before and after mapping were visualized in the 4DView which is a real-time 3D medical image visualization platform. With this method, the output format of EIM simulation data of LFX Virtual Cardiac Model was extended from 2D to 4D (time is the 4th dimension) and from cardiac model with realistic geometry to real cardiac model. According to the EIM simulation data visualization results before and after mapping, the LFX virtual cardiac model shows its characteristics with more realistic and effective simulation.

Algorithms↗

[Purification and properties of thermostable catalase in engineered E. coli].

A thermostable catalase in engineered bacterium E. coli was purified to electrophoretic homogenenity by heat treatment, ammonium sulfate fractionation precipitation, DEAE-A50 ion exchange chromatography, HiPrep 16/10 Phenyl hydrophobic interaction chromatography and Superdex200 HR 10/30 size exclusion chromatography with 187.2-fold purification and 9.8% recovery. The optimum reaction temperature and pH of this recombinant catalase were 70 degrees C and 7.0 respectively. The catalase is stable below 60 degrees C and at pH range 3-8. The residual activity of the catalase was about 60% after treated at 70 degrees C for 60 minutes and 80 degrees C for 10 minutes. The apprant Km and Vmax value of the catalase were 7.75 mmol/L and 27.8 mmol.min-1.mg-1 respectively. The affects of some metal ions and compounds on this enzyme were shown. Zn2+, Ba2+, Mn2+ of 1 mmol/L could completely inactivate the enzyme, EDTA of 50 mmol/L had no affect on activity.

Barium↗

[A 3D real-time visualization system of medical image].

Based on the integration of the advanced visualization toolkit (VTK) and the real-time rendering System (VolumePro), 4D View, a 3D real-time visualization system of medical image, which applies real-time 3D medical image (such as MR, CT image, etc.) visualization and interaction was developed. Firstly the VTK, VolumePro and their integration were introduced briefly; then the system design and function template of 4D View system was discussed in detail; finally some visualization results acquired through 4D View was illustrated. According to the results, 4D View system can effectively resolve the poor real-time characteristic of 3D medical image visualization and interaction, so it will have a wide application area of the clinical diagnosis, therapy and medical research, etc in future.

Image Processing, Computer-Assisted↗