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Biomedical subjects

Joël Guigay

Publications and source records attributed to Joël Guigay.

6 recordsLinked to original sources
PubMed2005

Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung.

PURPOSE: To present a case of cancer-associated retinopathy (CAR) in a patient with small cell carcinoma of the lung and antiretinal antibodies who experienced visual symptoms before diagnosis of cancer. DESIGN: Case report. METHODS: A 61-year-old man with a sudden loss of vision and photophobia was referred to the ophthalmology service. Antiretinal antibodies were determined by Western blot analysis. RESULTS: The patient was found to have small cell carcinoma of the lung without metastasis and was surgically treated. His visual loss was asymmetrical. The full field ERG was normal, even though his vision in the right eye became progressively worse. The patient was treated with methylprednisolone and showed significant improvement. Before surgery, serum tests showed antiretinal protein 35-kD; 1 week after surgery, antiretinal protein 35-kD and 46-kD (alpha-enolase); and 1 month after surgery, anti-alpha-enolase. CONCLUSIONS: Typical visual symptoms for paraneoplastic retinopathy are not always present. The absence of antirecoverin antibodies does not exclude a diagnosis of CAR.

Autoantibodies↗
PubMed2003

[Advanced nonsmall cell lung cancer: importance of chemotherapy in the control of symptoms].

Chemotherapy in advanced non-small-cell lung cancer may be a controversy because it is only palliative and costly. Benefit of chemotherapy is nevertheless clear in survival and particularly life quality. Beside this technical criteria, two other factors have an impact on the therapeutic decision: symptom control and patient's personal expectations. The aim of the strategy is to determine an acceptable compromise in each situation.

Carcinoma, Non-Small-Cell Lung↗
PubMed2002

[An unusual mediastinal malignant tumor: thymic carcinoma].

Thymic carcinoma is a relatively rare neoplasm. Current incidence is difficult to assess. There is some controversy regarding its definition and its diagnostic criteria. We report a case of epidermoid carcinoma in a 48-year-old man located in the thymus area of the anterior mediastinum. Clinicopathological features and prognosis are reviewed.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Bronchoscopy with the Vision Sciences BF100 disposable-sheath device: French experience after 328 procedures.

BACKGROUND: In spite of adhesion to recommended disinfection procedures, the transmission of infections by bronchoscopes is a permanent problem. OBJECTIVE: The new device may prevent nosocomial infections because it consists of two parts: a specific bronchoscope Vision Sciences BF100 and a single-use protective sheath for each procedure. The aim of this paper is to report our practice and the difficulties encountered when using this system. METHODS: We report our experience from 1997 to 2002 after 328 elective and emergency endoscopic procedures with the BF100 device. In a retrospective study, we describe the population and the incidents during procedure. We discuss the impact of the use of BF100 on the cost of bronchoscopies. RESULTS: The major constraint is the care required in assembling the optical device and disposable sheath. The intrinsic qualities of the optics are confirmed; any sample may be taken although image quality and suction capacity are inferior to videoscopes. Maneuverability is inferior to videoscopes, but improves with a short experience. In addition, this device is expensive. CONCLUSIONS: The technical performances of the BF100 device are inferior to those of videoscopes but the concept of sterile single-use sheaths is able to prevent the nosocomial infections related to bronchoscopes. Because of the cost, examination with the BF100 should be reserved to patients with proved or suspected infection (multiresistant bacteria, tuberculosis, hepatitis C and B virus, HIV, prions) and immunosuppression (hematologic diseases).

Asepsis↗