Biomedical subjects

Joachim Stave

Publications and source records attributed to Joachim Stave.

3 recordsLinked to original sources

PubMed2002

Monitoring accommodative ciliary muscle function using three-dimensional ultrasound.

BACKGROUND: Our objective was to develop a three-dimensional high-resolution ultrasonic imaging technique to be utilized for in-vivo characterization of the ciliary body and the posterior iris. The benefit of this imaging in enhancing the quantification of the configurational changes in the ciliary body during accommodation is demonstrated. METHODS: Sequential ultrasound biomicroscopic images of the ciliary body region were obtained with a computer-controlled scanning device designed for use with a standard ultrasound biomicroscope for 3D imaging. Custom-made software allows online data collection, data analysis and 3D reconstruction in conjunction with commercially available VoxelView software. RESULTS: The three-dimensional presentation allows a close approximation of the ciliary muscle inside the ciliary body in vivo. We are able to distinguish and to analyze the changes in the muscle contour in different accommodation states. During accommodation a shift in the ciliary muscle center of gravity in a range of 0.04-0.26 mm (mean 0.13+/-0.06 mm) in the direction of the lens equator, with an interindividual variation and a small decrease with age, was observed. CONCLUSIONS: High-resolution ultrasound is a well established technique for in-vivo investigation of the anterior segment. Three-dimensional ultrasound biomicroscopy allows an assessment of the individual ciliary muscle activity in consideration of the ciliary processes. In combination with a contour analysis tool we improved the muscle contour determination during different accommodation states. The investigation showed an activity of the ciliary muscle in young volunteers as well as those of presbyopic age.

Accommodation, Ocular↗

PubMed2002

Depth and age-dependent distribution of keratocytes in healthy human corneas: a study using scanning-slit confocal microscopy in vivo.

PURPOSE: To document keratocyte distribution and changes with age in the cellular network of the human cornea in vivo. SETTING: Department of Ophthalmology, University of Rostock, Rostock, Germany. METHODS: Forty-nine eyes of 31 healthy subjects of various ages were examined with a modified Microphthal scanning-slit confocal microscope (SSCM) (Hund) to document keratocyte distribution in the intact living cornea. Optical sections made by confocal microscopy were recorded on videotape, and the keratocyte density was determined for the total volume of the cornea and for the stromal sublayers. RESULTS: The highest cell density was in the anterior stroma of the cornea immediately posterior to Bowman's membrane (24 320 cells/mm(3) +/- 6740 [SD]), the lowest in the central area (11,610 +/- 4290 cells/mm(3)), and an intermediate density in the posterior stroma immediately adjacent to Descemet's membrane (18,850 +/- 4610 cells/mm(3)). The differences were statistically significant (P <.005). The keratocyte density was significantly lower in the anterior and posterior regions in the group older than 50 years: Cell density at 4% depth was 20,960 +/- 8200 cells/mm(3) and at 96%, 15 520 +/- 4290 cells/mm(3) (P <.05). CONCLUSIONS: In healthy living corneas, the keratocyte density was high in the areas adjacent to Bowman's and Descemet's membranes and was lower in patients older than 50 years than in those younger than 50 years. Further studies are needed to document the rate of change with age and to better understand the role and capacity of aging keratocytes in regenerative processes following corneal diseases or surgical procedures.

Adult↗

PubMedDate not supplied

[Prof. Carl Wilhelm von Zehender (1819-1916)--first professor of ophthalmology and co-founder of the ophthalmological clinic at the University of Rostock--commemorative lecture at the 100th DOG meeting in Berlin from 26.9 to 29.9.2002].

The Grand-ducal University Eye Department in Rostock was solemnly inaugurated 16 May 1892. According to many years of studies in Europe and on efforts to build this clinic, construction was outlined by Professor Carl Wilhelm v. Zehender, but the drafts were executed by the "Grossherzoglich-Mecklenburgisch-Schwerinschen Medicinalcommission" and Landbaumeister Schlosser in winter 1888/89. Professor v. Zehender, who originated from a very ancient Swiss family, was born in Bremen, 21 May 1819. He studied medicine in Goettingen, Jena, Prague, Paris and Vienna. During this time he developed a lifelong friendship with Albrecht v. Graefe. 1856 he took over the medical care for the hereditary duke Georg von Mecklenburg-Strelitz and published the "Correspondenzblatt für Aerzte im Grossherzoglichen Mecklenburg-Strelitz". 1857, during a conference in Heidelberg, his initiative led in the long run to the establishment of the "Heidelberger Ophthalmologische Gesellschaft", the forerunner of the "Deutsche Ophthalmologische Gesellschaft", which was founded in 1920. In 1863 the first edition of "Klinische Monatsblaetter für Augenheilkunde" was published as a periodical; the cover page bore its name as the founder of the magazine. In 1866, after the death of the hereditary duke and a professorship in his hometown Berne, he became honorary professor of the Rostock University, and from 1869 onwards he chaired the clinic as a regular professor. After all his efforts to build his own hospital had failed, he demonstratively and finally resigned from his professorship in 1889. He went to Munich and became editor of the " Klinische Monatsblaetter für Augenheilkunde". In 1907 he moved with his wife via Eutin to Warnemuende. There the nestor of world ophthalmologists died at the age of 98. His burial place without gravestone is situated in today's landscape park "Stephan Jantzen". So far all efforts of the author and of the Rostock University Eye Department taken after 1980 to create a worthy note to this exceptional ophthalmologist in the Baltic Sea resort Warnemuende were unsuccessful, also for financial reasons. But on 2.9.2002 with the help of the Lighthouse Club of Warnemuende a memorial plaque to Prof. C. W. v. Zehender was mounted on the guest house "Margarete". This plaque commemorates Professor Zehender's merits in establishing the DOG, planning and building the eye clinic of the university of Rostock.

Germany↗