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Joanne Lee

Publications and source records attributed to Joanne Lee.

3 recordsLinked to original sources
PubMed2006

Hearing a face: cross-modal speaker matching using isolated visible speech.

An experiment was performed to test whether cross-modal speaker matches could be made using isolated visible speech movement information. Visible speech movements were isolated using a point-light technique. In five conditions, subjects were asked to match a voice to one of two (unimodal) speaking point-light faces on the basis of speaker identity. Two of these conditions were designed to maintain the idiosyncratic speech dynamics of the speakers, whereas three of the conditions deleted or distorted the dynamics in various ways. Some of these conditions also equated video frames across dynamically correct and distorted movements. The results revealed generally better matching performance in the conditions that maintained the correct speech dynamics than in those conditions that did not, despite containing exactly the same video frames. The results suggest that visible speech movements themselves can support cross-modal speaker matching.

Adolescent↗
PubMed2002

The effect of Neovastat (AE-941) on an experimental metastatic bone tumor model.

Bone metastases are generally associated with bone destruction which occurs in response to factors secreted by metastatic cells. Some of these factors secreted by the metastatic cells activate osteoclats while others are proteases that degrade bone collagen. To determine if Neovastat (AE-941), a naturally occurring multi-functional inhibitor of angiogenesis, is able to regulate properties that are thought to have relevance to their propensity to form bone metastases in vivo, we used the human breast cancer MDA-MB-231 cell line which can metastasize to bone. We showed that Neovastat prevented the degradation of osteoid-like radiolabeled extracellular matrices which was induced by incubation of human SaOS-2 osteoblast-like cells with MDA-MB-231 cells. Moreover, Neovastat was demonstrated to inhibit the gelatinolytic activity of matrix metalloproteinase (MMP)-9 expressed by MDA-MB-231 cells. The potential of Neovastat to retard the spread, growth, and osteolysis of MDA-MB-231 cells was then estimated in vivo. Histomorphometric analysis of the vertebral bodies indicated that MDA-MB-231 cells inoculated in nude mice (intracardiac) successfully generate osteolytic metastases with an 83% reduction of the volume of medullary bone (p< or =0.01). However, when tumor-bearing animals were treated orally with Neovastat, there was only a 19% decrease in medullary bone thus indicating that Neovastat can prevent bone metastasis in this model. Consistent with histological results, radiographic analysis indicated that Neovastat decreased the number of osteolytic lesions by 33% (p< or =0.3). Moreover, a decrease in the tumor volume in bone was observed in Neovastat-treated animals. These results indicate that Neovastat may be useful in preventing bone metastasis in cancer patients.

Angiogenesis Inhibitors↗