Joe Pater | PubMed Health

PubMed2005

Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.

BACKGROUND: The National Cancer Institute of Canada Clinical Trials Group undertook a multicenter, randomized, double-blind controlled trial of an oral antimicrobial versus placebo to prevent and treat mucositis. We present the quality of life (QOL) analysis for this trial. METHODS: One hundred thirty-eight patients were randomly assigned. QOL data were collected every 2 weeks before, during, and after radiotherapy. The European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ-C30) and a Trial Specific Checklist (TSC) were used. RESULTS: The antimicrobial lozenge did not impact QOL. The principal acute side effect of radiotherapy is oral pain, affecting more than 90% of patients. Role function is impacted during treatment, and patients experience fatigue. Appetite was reported to markedly increase during radiotherapy. There was a dramatic and persistent increase in dry mouth. CONCLUSIONS: This study highlights the benefits of combining the EORTC QLQ-30 with an "oral" TSC in a randomized controlled trial and provides valuable baseline data for their use with an objective mucositis scoring system.

Administration, Oral↗

PubMed2003

Constraint conflict in cluster reduction.

When children reduce onset clusters to singletons, a common pattern is for the least sonorous member of the adult cluster to be produced. Within optimality theory (Prince & Smolensky, 1993), this pattern has been accounted for in terms of a fixed ranking of onset constraints that evaluate a segment's degree of sonority, whereby onset glides violate the highest ranked constraint, and onset stops the lowest. Not all children follow the sonority pattern, however. In this paper, we apply two fundamental principles of optimality theory to yield predictions about other children's cluster reduction patterns. The first principle is that of factorial typology, according to which all rankings of constraints should yield possible languages. To produce the sonority pattern, all conflicting constraints must rank beneath the onset sonority constraints. If they rank above the onset sonority constraints, these other constraints will force deviations from the sonority pattern. In this paper, we show how divergences from the sonority pattern are caused by three well-motivated conflicting constraints: *Fricative, *Dorsal, and Max-Labial. This is documented in the speech of two normally developing children (about 1;6-2;3) and a child with a phonological delay (3;8). The second principle we appeal to is that of emergent constraint activity, according to which the effects of violated constraints can be observed when higher ranked conflicting constraints are not at issue. We show that even when the onset sonority constraints are outranked by the conflicting constraints, under the right circumstances the sonority pattern does emerge in the forms produced by these children.

Child Language↗