Biomedical subjects

John B Weaver

Publications and source records attributed to John B Weaver.

5 recordsLinked to original sources

PubMed2005

Imaging the shear modulus of the heel fat pads.

BACKGROUND: Steady state, dynamic MR elastography provides quantitative images of the shear modulus of tissues in vivo. MR elastography was evaluated for its ability to characterize the mechanical properties of the weight bearing plantar soft tissues in vivo. METHODS: MR elastography was used to image the heel fat pad and surrounding soft tissues when the subject applied a low pressure on the foot and again when the subject applied high pressure. The placement of the foot was identical for both sets of images. FINDINGS: The results agree well with expected trends. The shear modulus of the tissue under the calcaneus increased from 8 kPa to 12 kPa with increasing pressure while that of peripheral tissues remained constant at 8 kPa which is similar to the shear modulus of fat in breast tissue. INTERPRETATION: Preliminary results from the steady state MR elastography methods being developed to measure the shear modulus of plantar soft tissues are promising. MR elastography is sufficiently accurate to observe the change in shear modulus with changes in applied pressure and is capable of characterizing the mechanical properties of the plantar soft tissues. Detailed anatomic information can be combined with co-registered mechanical properties. MR elastography could play a significant role in understanding the weight bearing functions of the plantar soft tissues and in evaluating those structures for improved diagnosis and assessment of disease progression.

Adipose Tissue↗

PubMed2005

A three-parameter mechanical property reconstruction method for MR-based elastic property imaging.

A reconstruction process featuring full parameterization of the three dimensional, time-harmonic equations of linear elasticity is developed and reconstructed property images are presented from simulation-based investigation. While interesting in its own right through the potential for increased adaptability of these reconstructive elastic imaging techniques, this study also presents a set of analysis tools used to study the poor convergence behavior found in the case of tissue like conditions (i.e. nearly incompressible materials). The choice of elastic properties for imaging in elastography research remains an open question at this point; the use of the stability and sensitivity-based analytical methods described here will help to predict and understand the value and reliability of different parameterizations of elasticity imaging. Additionally, though results indicate significant work needs to be done to achieve effective multiparameter reconstructive imaging, the methods detailed here offer the promise of increased flexibility and sophistication in elastographic imaging techniques.

Algorithms↗

PubMed2004

Shear modulus estimation using parallelized partial volumetric reconstruction.

Magnetic resonance elastography can be limited by the computationally intensive nonlinear inversion schemes that are sometimes employed to estimate shear modulus from externally induced internal tissue displacements. Consequently, we have developed a parallelized partial volume reconstruction approach to overcome this limitation. In this paper, we report results from experiments conducted on breast phantoms and human volunteers to validate the proposed technique. More specifically, we demonstrate that computational cost is linearly related to the number of subzones used during image recovery and that both subzone parallelization and partial volume domain reduction decrease execution time accordingly. Importantly, elastograms computed based on the parallelized partial volume technique are not degraded in terms of either image quality or accuracy relative to their full volume counterparts provided that the estimation domain is sufficiently large to negate the effects of boundary conditions. The clinical results presented in this paper are clearly preliminary; however, the parallelized partial volume reconstruction approach performs sufficiently well to warrant more in-depth clinical evaluation.

Breast Neoplasms↗

PubMed2003

Initial in vivo experience with steady-state subzone-based MR elastography of the human breast.

PURPOSE: To describe initial in vivo experiences with a subzone-based, steady-state MR elastography (MRE) method. This sparse collection of in vivo results is intended to shed light on some of the strengths and weaknesses of existing clinical MRE approaches and to indicate important areas of future research. MATERIALS AND METHODS: Elastic property reconstruction results are compared with data compiled from the limited existing body of published studies in breast elasticity. Mechanical parameter distributions are also investigated in terms of their implications for the nature of biological soft tissue. Additionally, a derivation of the statistical variance of the elastic parameter reconstruction is given and the resulting confidence intervals (CIs) for different parameter solutions are examined. RESULTS: By comparison with existing estimates of the elastic properties of breast tissue, the subzone-based, steady-state MRE method is seen to produce reasonable estimates for the mechanical properties of in vivo tissue. CONCLUSION: MRE shows potential as an effective way to determine the elastic properties of breast tissue, and may be of significant clinical interest.

Adipose Tissue↗

PubMed2003

Thresholds for detecting and characterizing focal lesions using steady-state MR elastography.

An objective contrast-detail analysis was performed in this study to assess the low contrast detectability of a clinical prototype harmonic magnetic resonance elastographic imaging system. Elastographic imaging was performed on gelatin phantoms containing spherical inclusions of varying size and modulus contrast. The results demonstrate that lesions as small as 5 mm can be detected with a minimum modulus contrast of 14 dB. However, the shear modulus of such small lesions was not accurately recovered. In general, the shear modulus of larger focal lesions was accurately (i.e., within 25% of the true value) recovered. The minimum modulus contrast needed to detect focal lesions was observed to decrease with increasing lesion size.

Algorithms↗