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Biomedical subjects

John Burkhardt

Publications and source records attributed to John Burkhardt.

4 recordsLinked to original sources

Predictors of emergency department observation unit outcomes.

BACKGROUND: Acute decompensated heart failure (adHF) is the cause of approximately 1 million annual hospital admissions. In some of these, the use of a short-stay emergency department observation unit (EDOU) decreases 90-day ED revisits and 90-day rehospitalizations and, if subsequent hospitalization is required, results in shorter stays. OBJECTIVES: To determine whether laboratory and clinical parameters, available at ED arrival, predict successful EDOU discharge. METHODS: This was a 19-month retrospective analysis of adHF EDOU admissions. Details of medical history, clinical course, patient management, laboratory data, and disposition destination were gathered through review of electronic medical records. Recorded laboratory data included measurements of sodium, creatinine, blood urea nitrogen (BUN), hemoglobin, b-type natriuretic peptide, and initial ED systolic blood pressure. Data were analyzed for ability to predict the requirement of hospital admission after EDOU management. RESULTS: There were 385 patients were enrolled. The mean (+/- standard deviation) age was 69.7 (+/- 13.6) years, and 50.1% were female. On ED admission chest radiograph, 69.0% had evidence of pulmonary edema. Elevations in creatinine and BUN levels had statistically significant associations with admission; however, on multivariable analysis, only a BUN value >30 mg/dL significantly predicted EDOU management failure, and subsequent inpatient admission. CONCLUSIONS: These results demonstrate that a BUN level >30 mg/dL is associated with an increased likelihood of admission in patients with adHF. This provides the emergency physician with a practical prognostic tool for disposition planning in congestive heart failure patients.

Adult↗

Remote interrogation and monitoring of implantable cardioverter defibrillators.

CONTEXT: The rate of ICD implantation of has grown substantially after results of primary and secondary prevention trials have demonstrated mortality superiority over pharmacologic therapy. Although transtelephonic monitoring is routine for pacemaker follow-up there is no systematically collected data supporting remote interrogation and monitoring (RIM) of ICD patients. OBJECTIVE: To prospectively measure the physician and patient acceptability, diagnostic value and safety of systematic periodic RIM of ICDS. METHODS: 124 patients with single chamber ICDs were monitored by remote RIM and by annual outpatient ICD analysis. Patients could initiate additional remote interrogations due to symptoms and physicians could increase the frequency of remote interrogations to monitor elective replacement indicators or if the device was identified as requiring more frequent follow-up. Outpatient clinic analysis was used to investigate abnormal remote interrogations. MAIN OUTCOME MEASURES: SF-36 and patient satisfaction surveys were obtained at baseline, at 3 and 6 months. RESULTS: 570 transmissions (5.1 + 2.4 per patient) were received and showed 54 delivered and 22 aborted ICD therapies and 30 episodes of NSVT. SF-36 results were no different at baseline, 3 and 6 months. Out of the total patients enrolled in the study, 93-99% of patients indicated complete or high satisfaction with remote interrogation in the five measures used to gauge satisfaction. CONCLUSIONS: Remote ICD interrogation provides frequent, convenient, safe and comprehensive monitoring. Device and patient related problems were reliably detected and reduced the frequency of outpatient visits. Patients were highly satisfied with the convenience and ease of use of the system.

Defibrillators, Implantable↗

Microstructural characterization using diffuse backscatter: theory and experiment.

A microstructure characterization technique is presented which utilizes the azimuthal moments of backscattered intensity to determine the Legendre moments of the microstructure's phase function. The technique is based on a late-time, diffuse approximate solution to the radiative transfer equation. Monte Carlo simulations are presented indicating that the technique is robust for the first azimuthal moment but less so for higher-order moments.

Journal Article↗

Pressure generated on a simulated oral analog by impression materials in custom trays of different designs.

PURPOSE: To measure the pressure exerted by maxillary edentulous impressions composed of 3 commonly used impression materials using four different impression tray configurations. MATERIALS AND METHODS: The study was performed using an oral analog that simulated an edentulous maxillary arch. Three pressure transducers were imbedded in the oral analog, 1 in the mid-palate area and the other 2 in the right and left ridge (maxillary first premolar areas). Custom trays of 4 different configurations were fabricated. The 3 impression materials tested were irreversible hydrocolloid, light-body and medium-body vinyl polysiloxane, and polysulfide. A total of 128 impressions were made. The custom tray and the oral analog were mounted using a reline jig. A Satec universal testing machine was used to apply a constant pressure of 2 kg/cm(2) over a period of 5 minutes on the loaded custom tray. The pressure was recorded every 10 seconds. Factorial analysis of variance and Tukey's multiple comparison test were used to analyze the results. RESULTS: A significant difference in the pressure produced using different impression materials was found (p < or =0.001). Irreversible hydrocolloid and medium-body vinyl polysiloxane produced a significantly higher pressure than light-body vinyl polysiloxane and polysulfide impression materials. The presence of holes and/or relief did not significantly alter the magnitude of pressure. CONCLUSION: All impression materials produced pressure during maxillary edentulous impression making. Tray modification was not important in changing the amount of pressure produced. The impression materials used had more effect on the pressure produced during impression making on the simulated oral analog.

Alginates↗