Words derived from the noun peptide.
Modifications of the noun peptide are explored and clarified; a few are condemned.
Peptides↗
Biomedical subjects
John H Jones
Publications and source records attributed to John H Jones.
Abbreviations and symbols in peptide science: a revised guide and commentary.
The abbreviations and symbols used in Peptide Science are surveyed, with comment and recommendations.
Abbreviations as Topic↗
Cyclic oligomers of oxetane-based dipeptide isosteres derived from L-rhamnose.
Two new cyclic oligomers, cyclo-tetra-[2,4-anhydro-3-O-tert-butyldimethylsilyl-5-deoxy-L-rhamnonamido-(N-->5)] and the corresponding 6-deoxy-D-gulonate cyclic "tetramer", have been synthesised from linear tetrameric oligomers, using TBTU- and pentafluorophenyl ester-based methodologies, respectively. These two compounds constitute a novel class of cyclic oligomers derived from oxetane-based sugar amino acids.
Dipeptides↗
The shifting sands of serials bibliography: titles using the term "peptide".
A commentary on the confusing nomenclature and bibliography of serial publications which use the term "peptide" in their titles is given, with guidance on citation.
Bibliometrics↗
Cysteine methyl ester modified glassy carbon spheres for removal of toxic heavy metals from aqueous media.
Glassy carbon spherical powder (10-20 microm diameter) modified with cysteine methyl ester is found to be an inexpensive, novel material for the rapid removal of large quantities of toxic heavy metal ions such as Cd(II), Cu(II) and As(III) from aqueous media, with wide ranging potential applications such as third world drinking water filtration or environmental cleanup.
Journal Article↗
The synthesis of oligomers of oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose.
Routes to oligomers (dimers, tetramers, hexamers) of five oxetane-based dipeptide isosteres have been established. Methyl 2,4-anhydro-5-azido-5-deoxy-L-rhamnonate 'monomer' led, by coupling the corresponding carboxylic acid and amine, to a 'dimer'. Reverse-aldol ring-opening occurred on attempted saponification of the dimer, so all further oligomerization was performed using TBDMS C-3 hydroxyl protection. The silyl protected L-rhamnonate monomer led in turn to the dimer (via the monomer acid and amine), the tetramer (via the dimer acid and amine) and finally the hexamer (via the tetramer acid and dimer amine). In each case the acids were obtained through saponification of the respective methyl esters and the amines were obtained by hydrogenation of the azides; coupling was TBTU-mediated. Essentially the same strategy was employed on equivalent D-lyxonate, 6-deoxy-L-altronate, 6-deoxy-D-gulonate and D-fuconate dipeptide isosteres to give the respective dimers, tetramers and hexamers.
Dipeptides↗
Conformational studies of oligomeric oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose.
Conformational investigations have been undertaken on oligomers (dimers, tetramers, hexamers) of five closely related oxetane-based dipeptide isosteres. All the oligomers were subjected to a range of studies by NMR, FT-IR and CD spectroscopy. The oligomers derived from methyl 2,4-anhydro-5-azido-3-O-tert-butyldimethylsilyl-5-deoxy-L-rhamnonate 'monomer' all exhibited evidence of ordered conformations in chloroform and 2,2,2-trifluoroethanol (TFE) solution. 5-Acetamido and N-methylamide derivatives of the L-rhamnonate 'monomer', along with a 'dimer' lacking silyl protection at C-3, were synthesized to ascertain the role of intramolecular interactions. This led to the conclusion that, for the L-rhamnonate oligomers, steric interactions govern the conformational preference observed. The equivalent silyl-protected D-lyxonate oligomers gave ordered CD spectra in TFE solution, but NMR and FT-IR spectroscopy in chloroform solution suggested an irregular, non-hydrogen bonded system. The remaining silyl-protected 6-deoxy-L-altronate, 6-deoxy-D-gulonate and D-fuconate oligomers appear to be characterized by their lack of ordered conformation in TFE and chloroform solution.
Circular Dichroism↗
An unsaturated peptidomimetic assembly derived from a carbohydrate.
A strategy has been established for the synthesis of peptidomimetics derived from unsaturated carbohydrates, and exemplified by the use of methyl 2,6-anhydro-7-azido-3,7-deoxy-4,5-O-isopropylidene-D-lyxo-hept-2-enonate 9 as a dipeptide 'monomer' which can be elaborated from either end. Selective reduction of 9 gives a protected pseudodipeptide ester suitable for use as an amino component, and saponification gives an azido acid suitable for use as a carboxyl component. The 'dimer' product of coupling these two components with TBTU can be similarly elaborated at either end to give a 'trimer' and a further cycle of selective reduction and coupling gave a 'tetramer', 17, a pseudo-octapeptide.
Amino Sugars↗
A revised guide to abbreviations in peptide science and a plea for conformity.
Explore the source record for details and available documents.
Peptides↗
The terminology of guanidine formation.
The terminology in recent use for the conversion -NH2 to -NHC(=NH)NH2 is surveyed and shown to be in a state of extreme confusion: a pragmatic recommendation is made that the word guanidinylation should be generally adopted for this conversion.
Guanidine↗