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Biomedical subjects

John K Borchardt

Publications and source records attributed to John K Borchardt.

8 recordsLinked to original sources
PubMed2006

Focus on new antiviral drugs for AIDS and smallpox treatments.

More than 400 papers on medicinal chemistry were presented at the 231st National Meeting of the American Chemical Society in Atlanta, Georgia, U.S.A., March 26-30, 2006. A major focus was a large number of papers on new AIDS drug therapies being developed. The rapid development of HIV viral mutations is one reason expensive highly active antiretroviral therapy multidrug treatments are preferred. This increasing resistance of HIV to current drugs is spurring new drug development. In addition, concerns about bioterrorism have awakened interest in drug treatments for a viral disease once thought to be extinct, smallpox. This report will focus on these areas of research.

Acquired Immunodeficiency Syndrome↗
PubMed2004

The history of bacterial meningitis treatment.

Few diseases have been affected more by the advent of antimicrobial therapy than bacterial meningitis. From its recognition in 1805 to the early 20th century, bacterial meningitis was deadly. The 1940s brought the advent of effective drug therapy. Bacterial meningitis remains common today with growing drug resistance to the disease organisms complicating antibiotic therapy.

Anti-Bacterial Agents↗
PubMed2004

Medicine of the Maya Ameridians.

While perhaps best known for their advanced calendars and knowledge of astronomy, the Maya also developed an advanced pharmaceutical science that has been maintained by their descendants. Because of the diverse habitats found in the region, from mountains to deep valleys, the complex ecosystem of the highland Maya is the world's third richest in numbers of vascular plant species. The rain forests of this area are a rich source of potential new drugs. According to the U.S. National Cancer Institute, more than 25% of the ingredients in today's cancer medicines were either discovered in rain forests or are analogues or derivatives of such compounds. Although much of the Mayan medical knowledge continues to be practiced by their descendants, the Mayan medical traditions are fading because of increased urbanization. Meanwhile, the source of their pharmacopeia is disappearing as the tropical rain forests are cleared for development. Consequently, measures to preserve this pharmaceutical knowledge are of great importance.

Humans↗
PubMed2004

Focus on small molecule inhibitors for treatment of inflammatory and autoimmune diseases.

The 228th American Chemical Society (ACS) National Meeting was held August 22-26, 2004, in Philadelphia, Pennsylvania. More than 400 medicinal chemistry papers were presented, most in symposia, general sessions and poster sessions sponsored by the ACS Division of Medicinal Chemistry. One major focus of the meeting was the development of novel drugs for the treatment of inflammatory and autoimmune diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease (Crohn's disease), psoriasis, reperfusion injury and endotoxic shock. This report will center on said areas of research.

Animals↗
PubMed2003

Traditional Chinese drug therapy.

More than 4,000 years old, traditional Chinese medicine continues to be widely practiced in China and in western countries. Traditional Chinese medicine teaches that good health is the result of harmony and balance between five basic elements: earth, water, fire, wood and metal. Also important to health are the two types of energy Yin and Yang, constituting a vital substance that circulates through the body. Drug therapy has been one of the means used in Chinese medicine to keep these elements and the flow of energy in balance. Many of the same herbs used thousands of years ago in China could be the source of new pharmaceuticals in Western medicine.

Alchemy↗
PubMed2003

Native American drug therapy: United States and Canada.

The more than one hundred different Native American Indian cultures of the United States and Canada developed a rich pharmacopoeia before contact with Europeans began in the fifteenth century. Together these Native American groups contributed 220 indigenous drugs to "The Pharmacopoeia of the United States of America". Some of these remedies are used today in North America, Europe and elsewhere.

Canada↗
PubMedDate not supplied

Beginnings of drug therapy: drug therapy in ancient India.

Four thousand years ago, the medical knowledge of the Indian subcontinent was codified into a system called the Ayurveda. Ayurveda remains a vital system of medicine and drug therapy in India and elsewhere. Plant alkaloids are the primary active ingredients of Ayurvedic drugs. Today the pharmacologically active ingredients of many Ayurvedic medicines are being identified and their usefulness in drug therapy being determined.

Alkaloids↗