Biomedical subjects

John P Forsyth

Publications and source records attributed to John P Forsyth.

10 recordsLinked to original sources

PubMed2006

Evaluative differential conditioning of disgust: a sticky form of relational learning that is resistant to extinction.

The present study sought to (a) test whether autonomic (i.e., electrodermal) and evaluative conditioning can be differentially established to verbal CSs, and (b) whether extinction procedures can reliably attenuate differential conditioned evaluative responding. Thirty undergraduates underwent a 10-min adaptation period followed by three consecutive conditioning phases: habituation, acquisition, and extinction. Conditioning involved participants viewing two semi-randomly presented words on a computer monitor. During acquisition, one word (CS+) was reliably paired 12 times with the UCS (pictorial stimuli depicting bodily mutilation), whereas the remaining word (CS-) was presented 12 times and reliably followed by neutral pictures (inanimate common objects). As predicted, electrodermal and evaluative responses during acquisition were of larger magnitude to the CS+ compared to the CS-. During extinction, participants continued to evaluate the CS+ as more disgusting relative to the CS-, whereas distress and fear-related emotional ratings attenuated across extinction trials. The implications of these findings for the modifiability of disgust-based evaluative responses in specific anxiety disorders will be discussed.

Adult↗

PubMed2006

Factor structure of the Tonic Immobility Scale in female sexual assault survivors: an exploratory and Confirmatory Factor Analysis.

Tonic immobility (TI) is an involuntary component of the fear response that is characterized by freezing or immobility in situations involving extreme fear coupled with physical restraint. The present investigation evaluated the factor structure of the Tonic Immobility Scale (TIS; Forsyth, J. P., Marx, B., Fusé, T. M. K., Heidt, J., & Gallup, G. G., Jr. (2000). The Tonic Immobility Scale. Albany, NY: Authors)--a newly developed measure to assess components of TI in female sexual assault survivors. Study 1 (N=88) consisted of an Exploratory Factor Analysis of sexual assault survivors' responses on the TIS, whereas Study 2 (N=191) involved a Confirmatory Factor Analysis (CFA) with a second independent sample of female sexual assault survivors. Findings from both studies suggest that the TIS is comprised of two independent factors: physical immobility and fear. Findings are discussed in terms of the theoretical and practical implications of the factor solution obtained, particularly with regard to evaluating TI in adult survivors of sexual assault.

Adolescent↗

PubMed2006

Repeated exposure to 20% CO2 challenge and risk for developing panic attacks: a controlled 6- and 12-month follow-up in a nonclinical sample.

Among ethical concerns associated with biological challenge procedures is the risk of potentiating panic attacks in otherwise healthy persons who have no history of panic. The aim of the present study was to determine if repeated exposure to 20% CO2 challenge increases the risk of developing panic attacks in a nonclinical sample. One hundred and fifty-five (39.5%) of 392 participants who underwent a 20% CO2 challenge procedure and 51 (63.0%) of 81 controls who breathed only room air were evaluated for panic attacks using the Panic Attack Questionnaire-Revised both at 6 and 12 months after the experiment. The percentage of participants who developed subsequent panic attacks did not differ significantly between the CO2 challenge group and the room air controls. High dose CO2 challenge does not increase the risk of subsequent panic attacks in nonclinical populations; it is a safe paradigm for use in psychopathology research with healthy individuals.

Administration, Inhalation↗

PubMed2006

Experiential avoidance as a generalized psychological vulnerability: comparisons with coping and emotion regulation strategies.

Extending previous work, we conducted two studies concerning the toxic influences of experiential avoidance (EA) as a core mechanism in the development and maintenance of psychological distress, and disruption of pleasant, engaging, and spontaneous activity. Of particular interest was whether EA accounted for relationships between coping and emotion regulation strategies on anxiety-related pathology (Study 1) and psychological distress and hedonic functioning over the course of a 21-day monitoring period (Study 2). In Study 1, EA mediated the effects of maladaptive coping, emotional responses styles, and uncontrollability on anxiety-related distress (e.g., anxiety sensitivity, trait anxiety, suffocation fears, and body sensation fears). In Study 2, EA completely mediated the effects of two emotion regulation strategies (i.e., suppression and reappraisal) on daily negative and positive experiences and was associated with diminished daily positive affective experiences and healthy life appraisals, diminished frequency of positive events and more frequent negative life events, and greater negative affective experiences. The present data show that cognitive reappraisal, a primary process of traditional cognitive-behavior therapy, was much less predictive of the quality of psychological experiences and events in everyday life compared with EA. Further consideration of experiential avoidance as a generalized diathesis and toxic process will be useful in improving our understanding of the etiology, phenomenology, and treatment of anxiety conditions, general human suffering, and disruptions in hedonic capacity.

Adaptation, Psychological↗

PubMed2006

A derived transfer of simple discrimination and self-reported arousal functions in spider fearful and non-spider-fearful participants.

Two experiments investigated the derived transfer of functions through equivalence relations established using a stimulus pairing observation procedure. In Experiment 1, participants were trained on a simple discrimination (A1+/A2-) and then a stimulus pairing observation procedure was used to establish 4 stimulus pairings (A1-B1, A2-B2, B1-C1, B2-C2). Subsequently, a transfer of the simple discrimination functions through equivalence relations was observed (e.g., C1+/C2-). These procedures were modified in Experiment 2, which demonstrated that spider-fearful and non-spider-fearful participants show differing levels of a transfer of self-reported arousal functions for stimuli used in equivalence relations with video-based material depicting scenes with spiders. The results demonstrate that the stimulus pairing observation procedure provides a viable alternative to matching-to-sample, and also offer tentative support for a derived-relations model of the acquisition of anxiety responses in at least one sub-clinical population.

Animals↗

PubMed2005

Sex differences in response to a panicogenic challenge procedure: an experimental evaluation of panic vulnerability in a non-clinical sample.

Epidemiological studies show that women are twice as likely as men to develop panic disorder (PD) during their lifetimes. Data from retrospective studies also suggest that women are more distressed by panic and other negative emotional states than men, and that this tendency may precede the development of PD. The present prospective study sought to expand this work by evaluating sex differences in the predisposition to panic in individuals without PD or other forms of psychopathology. Participants (N=96; 52 women) were exposed to 12 panicogenic inhalations of 20% CO2-enriched air while physiological (e.g., heart rate, electrodermal response, Frontalis EMG) and self-report (e.g., subject distress, fear, frequency and severity of DSM-IV panic symptoms) response domains were monitored. As expected, magnitude of autonomic responding failed to reliably discriminate between women and men. Yet, women reported more fear and panic immediately following the challenge procedure relative to men, and this sex difference persisted when assessed again 30 min post-challenge. Implications of these results are discussed broadly in the context of biopsychosocial accounts of sex differences in the clinical presentation of PD.

Adolescent↗

PubMed2005

Tonic immobility and childhood sexual abuse: a preliminary report evaluating the sequela of rape-induced paralysis.

The present study examined tonic immobility (TI) in victims of childhood sexual abuse (CSA). Female undergraduates (n=39) and female psychiatric inpatients (n=41) who experienced CSA completed a series of questionnaires assessing aspects of their victimization history, psychological functioning, and TI symptoms. Over fifty-two percent of all participants reported TI in response to CSA. Episodes of CSA involving attempted or completed penile/vaginal penetration were more likely to be associated with an increased likelihood of experiencing TI, and report of TI was associated with greater current psychological impairment. The implications of these findings are discussed, and suggestions for future research are offered.

Adolescent↗

PubMed2005

Evaluating the role of panic disorder in emotional sensitivity processes involved with smoking.

The present study investigated the relationship between panic disorder and emotional sensitivity processes related to smoking. Participants were 170 young adult (mean age = 25.2 [8.4]) regular smokers (mean cigarettes per day = 15.6 [2.4]) with (n = 69) and without (n = 101) a primary diagnosis of panic disorder. Consistent with prediction, smokers with panic disorder showed greater motivation to smoke in order to reduce negative affect (but not other reasons for smoking), reported anxiety symptoms but not non-anxiety symptoms as problematic obstacles to quitting during past (lifetime) quit attempts, and reported lower levels of confidence in remaining abstinent when emotionally distressed. Results are discussed in relation to panic-relevant emotional sensitivity processes involved with smoking.

Adult↗

PubMed2003

Anxiety sensitivity, controllability, and experiential avoidance and their relation to drug of choice and addiction severity in a residential sample of substance-abusing veterans.

The aim of the present study was to evaluate anxiety-related psychological risk factors (e.g., anxiety sensitivity, perceived uncontrollability, emotional avoidance) and their relation to drug of choice and addiction severity in an inpatient residential substance abuse population. Fully detoxified veterans (N=94) meeting criteria for Axis I substance abuse disorders were enrolled in a 28-day residential substance abuse treatment program and completed the following measures at intake and discharge: Anxiety Sensitivity Index, Body Sensations Questionnaire (BSQ), Acceptance and Action Questionnaire (AAQ), Beck Depression Inventory (BDI; intake only), and the Anxiety Control Questionnaire (ACQ). Consistent with the expectation, veterans who reported more distress over bodily sensations (anxiety sensitivity, BSQ) and depressive symptoms (BDI) were more likely to avoid experiencing negative affect (AAQ) and perceived themselves as lacking in control (ACQ). Further, extent of avoidance, and to a lesser extent, controllability, discriminated between participants as a function of primary and comorbid diagnostic status, whereas anxiety sensitivity did not. No relation was found between anxiety sensitivity and drug of choice, and relations between assessed psychological factors and domains of addiction severity were mixed. Findings suggest that heightened bodily sensitivity, emotional avoidance, and perceived uncontrollability are common sequelae of patients seeking residential substance abuse treatment, but they do not contribute uniquely to drug of choice and measures of addiction severity. Theoretical and treatment implications are discussed with particular emphasis on approaches that may increase coping with untoward bodily cues, decrease avoidance of negative affect, and improve patient's sense of personal control over their responses and the environment.

Adult↗

PubMed2002

Classification of panic attack subtypes in patients and normal controls in response to biological challenge: implications for assessment and treatment.

Panic attacks are symptomatically heterogeneous but efforts to describe such heterogeneity are relatively new. With regard to symptom presentation, at least three types of panic attack have been proposed based on the coupling or decoupling of verbal-cognitive and physiological symptoms: prototypic, cognitive, and nonfearful panic. The central aim of the present study was to address whether patients with panic disorder (PD) and nonclinical controls (NC) could be classified and discriminated (within and between groups) in terms of subtypes of panic attacks based on convergence and divergence of physiological and subjective arousal. Two samples of patients with PD (n = 94) and NC (n = 70) were exposed to single-breath vital capacity (VC) inhalations of 35% CO2/65% O2. Subjective anxiety and cardiovascular (heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DSP)) reactivity to the challenge were measured. For reactive participants, response patterns suggested the production of differentiated and stable panic attack subtypes described as: (1) prototypical (high subjective, high physiological), (2) cognitive (high subjective, low physiological), and (3) nonfearful (low subjective, high physiological). Subtype frequency differed between groups (prototypical: 33% PD, 8% NC; cognitive: 37% PD, 4% NC; nonfearful: 11% PD, 42% NC). A panic attack typology based on convergence and divergence of different response systems appears to reliably discriminate patients with panic disorder and may have relevance for predicting clinical characteristics, treatment modality, and prognosis.

Adolescent↗