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Biomedical subjects

John P McCarthy

Publications and source records attributed to John P McCarthy.

7 recordsLinked to original sources
PubMed2006

Ethnic differences in triceps surae muscle-tendon complex and walking economy.

The purposes of this study were to (a) determine whether structural differences in triceps surae muscle-tendon complex and walking economy exist between 14 African American and 19 Caucasian sedentary women and (b) determine whether muscle-tendon parameters are associated with walking economy. African American and Caucasian subjects were matched on body weight, height, and body composition. Muscle-tendon parameters were determined by magnetic resonance imaging and walking economy was evaluated at 4.8 km.h(-1). Medial gastrocnemius and total triceps surae muscle shape were different across ethnicity despite no ethnic differences in plantar flexion strength or in maximal cross-sectional area for any triceps surae muscles. African American women had shorter gastrocnemius muscles and longer tendons and performed walking more economically. Tendon length was the only variable related to walking economy. No ethnic differences were observed in walking economy after adjusting for tendon length. Data show gastrocnemius tendon length is related to level walking and longer gastrocnemius tendons may partly explain more economical walking in African American women. These preliminary findings indicate the structure of the muscle-tendon complex could be a factor partially accounting for reported ethnic differences in certain types of athletic-related performance.

Adult↗
PubMed2005

Inverse relationship between exercise economy and oxidative capacity in muscle.

An inverse relationship has been shown between running and cycling exercise economy and maximum oxygen uptake (VO2max). The purposes were: 1) determine the relationship between walking economy and VO2max; and 2) determine the relationship between muscle metabolic economy and muscle oxidative capacity and fiber type. Subjects were 77 premenopausal normal weight women. Walking economy (1/VO2max) was measured at 3 mph and VO2max during graded treadmill test. Muscle oxidative phosphorylation rate (OxPhos), and muscle metabolic economy (force/ATP) were measured in calf muscle using 31P MRS during isometric plantar flexion at 70 and 100% of maximum force, (HI) and (MI) respectively. Muscle fiber type and citrate synthase activity were determined in the lateral gastrocnemius. Significant inverse relationships (r from -0.28 to -0.74) were observed between oxidative metabolism measures and exercise economy (walking and muscle). Type IIa fiber distribution was inversely related to all measures of exercise economy (r from -0.51 to -0.64) and citrate synthase activity was inversely related to muscle metabolic economy at MI (r = -0.56). In addition, Type IIa fiber distribution and citrate synthase activity were positively related to VO2max and muscle OxPhos at HI and MI (r from 0.49 to 0.70). Type I fiber distribution was not related to any measure of exercise economy or oxidative capacity. Our results support the concept that exercise economy and oxidative capacity are inversely related. We have demonstrated this inverse relationship in women both by indirect calorimetry during walking and in muscle tissue by 31P MRS.

Adult↗
PubMed2004

Effects of resistance training on older adults.

Using an integrative approach, this review highlights the benefits of resistance training toward improvements in functional status, health and quality of life among older adults. Sarcopenia (i.e. muscle atrophy) and loss of strength are known to occur with age. While its aetiology is poorly understood, the multifactorial sequelae of sarcopenia are well documented and present a major public health concern to our aging population, as both the quality of life and the likelihood of age-associated declines in health status are influenced. These age-related declines in health include decreased energy expenditure at rest and during exercise, and increased body fat and its accompanying increased dyslipidaemia and reduced insulin sensitivity. Quality of life is affected by reduced strength and endurance and increased difficulty in being physically active. Strength and muscle mass are increased following resistance training in older adults through a poorly understood series of events that appears to involve the recruitment of satellite cells to support hypertrophy of mature myofibres. Muscle quality (strength relative to muscle mass) also increases with resistance training in older adults possibly for a number of reasons, including increased ability to neurally activate motor units and increased high-energy phosphate availability. Resistance training in older adults also increases power, reduces the difficulty of performing daily tasks, enhances energy expenditure and body composition, and promotes participation in spontaneous physical activity. Impairment in strength development may result when aerobic training is added to resistance training but can be avoided with training limited to 3 days/week.

Aged↗
PubMed2003

Muscle metabolic function, exercise performance, and weight gain.

PURPOSE: The study purpose was to determine the relationship: 1) of muscle metabolism to exercise performance and 2) of exercise performance to rate of weight gain. METHODS: Eighty-three black and white premenopausal women were evaluated for maximum oxygen uptake (VO2max ), isometric quadriceps and triceps surae strength, and 31P magnetic resonance spectroscopy of calf muscle metabolic capacity. Rate of weight gain was determined 1 yr later. Multiple regression was used to model dependent variables. RESULTS: Muscle aerobic capacity and strength of the quadriceps muscle independently contributed to endurance time on the treadmill (ET) in one model (overall R = 0.47, P < 0.01), and VO2max and strength of the quadriceps muscle independently contributed to ET in another model (R = 0.85, P < 0.001). In models of muscle strength, maximum creatine kinase activity and maximum anaerobic glycolytic rate independently contributed to triceps surae strength, after adjusting for triceps surae cross-section area (R = 0.63, P < 0.001). In another model, maximum creatine kinase activity was related to quadriceps strength independent of leg lean tissue (R = 0.31, P < 0.05). Rate of weight gain was related to muscle metabolic economy (r = -0.25, = 0.04), quadriceps strength (r = -0.34, P < 0.01), VO2max (r = -0.22, = 0.04), and ET (r = -0.21, = 0.04). Rate of weight gain was modeled by muscle metabolic economy, VO2max, and quadriceps strength (R = 0.48, P < 0.01). CONCLUSIONS: Implications of findings are 1) greater strength and aerobic fitness-at the muscle and whole-body levels-improve endurance; 2) greater muscle anaerobic metabolism is associated with greater muscle strength, independent of muscle size; and 3) greater exercise endurance reduces weight gain.

Adult↗
PubMed2002

Neuromuscular adaptations to concurrent strength and endurance training.

PURPOSE: The purpose of this study was to examine muscle morphological and neural activation adaptations resulting from the interaction between concurrent strength and endurance training. METHODS: Thirty sedentary healthy male subjects were randomly assigned to one of three training groups that performed 10 wk of 3-d x wk(-1) high-intensity strength training (S), cycle endurance training (E), or concurrent strength and endurance training (CC). Strength, quadriceps-muscle biopsies, computed tomography scans at mid-thigh, and surface electromyogram (EMG) assessments were made before and after training. RESULTS: S and CC groups demonstrated similar increases (P < 0.0001) in both thigh extensor (12 and 14%) and flexor/adductor (7 and 6%) muscle areas. Type II myofiber areas similarly increased (P < 0.002) in both S (24%) and CC (28%) groups, whereas the increase (P < 0.004) in Type I area with S training (19%) was also similar to the nonsignificant (P = 0.041) increase with CC training (13%). Significant increases (P < 0.005) in maximal isometric knee-extension torque were accompanied by nonsignificant (P 0.38) in the EMG/torque relation across 20 to 100% maximal voluntary contractions occurred in any group. A small 3% increase (P < 0.01) in thigh extensor area was the only change in any of the above variables with E training. CONCLUSIONS: Findings indicate 3-d x wk(-1) concurrent performance of both strength and endurance training does not impair adaptations in strength, muscle hypertrophy, and neural activation induced by strength training alone. Results provide a physiological basis to support several performance studies that consistently indicate 3-d x wk(-1) concurrent training does not impair strength development over the short term.

Adaptation, Physiological↗
PubMedDate not supplied

Cardiovascular factors explain genetic background differences in VO2max.

The purpose of this study was to further explore factors that may be related to ethnic differences in the maximum rate at which an individual can consume oxygen (VO2max) between 20 African American (AA) and 30 European American (EA) sedentary women who were matched for body weight (kg) and fat-free mass (FFM). VO2max (l/min) was determined during a graded treadmill exercise test. Submaximal steady-state heart rate and submaximal VO2 were determined at a treadmill speed of 1.3 m/sec and a 2.5% grade. Hemoglobin (Hb) was determined by the cyanide method, muscle oxidative capacity by 31P magnetic resonance spectroscopy (ADP time constant), and FFM (kg) by dual-energy x-ray absorptiometry. Genetic classification was self-reported, and in a subset of the sample (N = 32), the determinants of ethnicity were measured by African genetic admixture. AA women had significantly reduced VO2max, Hb levels, and muscle oxidative capacity (longer ADP time constants, P < or = 0.05) than EA women. Submaximal oxygen pulse (O2Psubmax), ADP time constant, Hb, and ethnic background were all significantly related to VO2max (ml/kg/min and ml/kg FFM/min, all P < or = 0.01). By multiple regression modeling, Hb, O2Psubmax, muscle oxidative capacity, and ethnicity were found to explain 61% and 57% of the variance of VO2max in ml/kg/min and ml/kg FFM/min, respectively. Muscle oxidative capacity and O2Psubmax were both significantly and independently related to VO2max in all three models (P < or = 0.05), whereas Hb and ethnicity were not. These results suggest that mitochondrial muscle oxidative capacity and oxygen delivery capabilities, as determined by O2Psubmax, account for most if not all of the ethnic differences in VO2max.

Adenosine Diphosphate↗