PubMed Health⌕ Search

Biomedical subjects

John Wilding

Publications and source records attributed to John Wilding.

10 recordsLinked to original sources
PubMed2006

Student anxiety and depression: comparison of questionnaire and interview assessments.

BACKGROUND: Recent reports note a reliance on self-report measures and a lack of information about diagnosable mental disorder in university students. Professional concern about perceived increases in student mental health problems raises questions about whether questionnaire assessments can provide valid approximations of such disorders in this group. The aim of this study was to validate the Hospital Anxiety and Depression Scale (HADS) against DSM-IV diagnoses in university students. METHODS: Eighty-nine students were administered with the HADS followed by the Structured Interview for DSM-IV. RESULTS: At recommended cut-offs HADS anxiety and depression scales both showed good sensitivity in detecting DSM-IV anxiety and depression disorders, and the depression scale showed good specificity and overall efficiency. The HADS anxiety scale showed poor specificity and moderate overall efficiency. In the absence of an anxiety diagnosis, high HADS anxiety scores were not significantly associated with other measured indicators of serious mental health problems. LIMITATIONS: Further research is needed to investigate whether the current findings hold for student populations with higher social diversity. CONCLUSIONS: The HADS depression scale is likely to be a reasonably accurate indicator of depressive conditions in university students at the recommended cut-off but the HADS anxiety scale overestimates the extent of clinical anxiety. Students' self-reported higher symptom levels in comparison to general population norms cannot be assumed to indicate higher levels of more serious mental health conditions. However this is not to deny the genuine distress and severe problems that some students experience.

Adult↗
PubMed2006

Life goals, approaches to study and performance in an undergraduate cohort.

BACKGROUND: Two main approaches to studying have been distinguished by several researchers, the deep approach and the surface approach. In addition, an achieving or strategic approach employs either deep or surface strategies, depending on the demands of the task. AIMS: The present study investigated factors contributing to the choice of preferred study approach at university and relations between these factors and academic performance. METHOD: A questionnaire was mailed to a complete cohort of entrants in a college of London University in the UK. A further questionnaire was sent part way through the second year of the course. RESULTS: Consistent relations were found between general life goals and approaches to study, with the deep approach being associated with altruistic life goals and the surface approach being associated with wealth and status life goals. The achieving approach was related to both types of life goal, but more strongly to wealth and status life goals. Older students, those with superior results in Advanced Level examinations, those reporting more use of the achieving approach, and those with less interest in wealth and status life goals, produced better academic results. Study approaches became more surface-oriented and less deep and achieving-oriented over the first year of study, but these changes were unrelated to academic performance. CONCLUSIONS: Approaches to study form part of a wider approach to life in general. Students adopting the achieving approach to study performed better. Though the achieving approach tended to weaken as the course proceeded, this change was unrelated to performance.

Adult↗
PubMed2004

Do women with fragile X syndrome have problems in switching attention: preliminary findings from ERP and fMRI.

Fragile X syndrome (FXS) is a neurodevelopmental disorder that represents the most common known cause of developmental delay. Recent neuropsychological findings indicate that females with FXS present with a specific pattern of cognitive deficits and that these difficulties primarily involve skills requiring executive control. The present study is the first to examine the extent to which neural activity of females with FXS can be observed on a task that specifically taps two core deficits, namely switching and response inhibition. Brain activity was measured using both event-related electrical potentials (ERPs) and event-related functional MRI (fMRI) neuroimaging in separate studies using the same cognitive paradigm. Compared to controls, females with FXS were significantly slower and made more errors on trials that required an immediate response (Go) to stimulus onset but were comparable on trials that required a delayed response (Wait) to stimulus onset. At the brain level, several areas showed significantly greater activation for females with FXS compared with controls, including the cingulate cortex and left and right ventral prefrontal areas. In contrast, no areas were found to show significantly greater activation for controls compared with females with FXS.

Adult↗
PubMed2004

Visual search in typically developing toddlers and toddlers with Fragile X or Williams syndrome.

Visual selective attention is the ability to attend to relevant visual information and ignore irrelevant stimuli. Little is known about its typical and atypical development in early childhood Experiment 1 investigates typically developing toddlers' visual search for multiple targets on a touch-screen. Time to hit a target, distance between successively touched items, accuracy and error types revealed changes in 2- and 3-year-olds' vulnerability to manipulations of the search display. Experiment 2 examined search performance by toddlers with Fragile X syndrome (FXS) or Williams syndrome (WS). Both of these groups produced equivalent mean time and distance per touch as typically developing toddlers matched by chronological or mental age; but both produced a larger number of errors. Toddlers with WS confused distractors with targets more than the other groups; while toddlers with FXS perseverated on previously found targets. These findings provide information on how visual search typically develops in toddlers, and reveal distinct search deficits for atypically developing toddlers.

Attention↗
PubMed2004

Clinical evaluation of anti-obesity drugs.

Obesity is a major health problem and as a result, it is reasonable to consider pharmacological approaches alongside approaches involving diet, physical activity and lifestyle change. The currently available drugs, sibutramine and orlistat, result in modest, clinically worthwhile weight loss, with demonstrable improvements in co-morbidity, but do not meet the often unrealistic expectations of patients or health care professionals managing obese patients. There is insufficient data on efficacy or safety of other agents to support their use. Many new pharmacological approaches are under investigation. These include gut hormones, such a peptide YY (3-36) and cholecystokinin that normally signal satiety, and centrally-acting agents such as serotonin agonists, the anticonvulsants topiramate and zonisamide, cannabinoid receptor antagonists and drugs that act on other peptide neurotransmitter systems such as NPY and the melanocortins. Given the multiple pathways that influence energy balance, it is likely that therapies targeting more than one control system may be required in the future to meet the expectations and needs of patients needing to lose weight for medical reasons.

Anti-Obesity Agents↗
PubMed2004

AOD-9604 Metabolic.

Metabolic is developing AOD-9604 for the potential treatment of obesity. By February 2002, phase IIa trials were underway.

Animals↗
PubMed2002

Further delineation of the executive deficit in males with fragile-X syndrome.

This paper presents a detailed analysis of one aspect of performance by young males with fragile-X syndrome (FMR-1 full mutation) who were assessed on a computerised visual search task as part of a larger study examining aspects of attention [Neuropsychologia 38 (2000) 1261]. They were matched on chronological and mental age to 25 boys with Down's syndrome (trisomy 21) and on mental age to 50 mainstream school boys (controls). The controls were further divided into those matched on "poor attention" to the fragile-X boys and a "good" attention group, as rated by the comprehensive teacher rating scale (ACTeRS) questionnaire. Both fragile-X and Down's syndrome boys made significantly more repeated responses on targets (but a lower proportion of errors based on confusion of shape) than the two control groups and these differences were stronger in the fragile-X group. In the single target condition, search was for a single type of target throughout. In the dual target condition, participants were required to alternate between two different targets. Fragile-X boys showed significantly greater inability than Down's syndrome and normal boys to switch attention between targets and both learning-disabled groups were inferior to the control groups. Thus, both learning-disabled groups displayed a weakness in inhibiting repetition and in switching attention from one type of target to another and the impairments were more acute in fragile-X boys. The results provide further support for an attention deficit in this population at higher levels of attention control/executive functioning that involve switching visual attention and inhibiting repetitious behaviour.

Adolescent↗
PubMed2001

The nature of attentional differences between groups of children differentiated by teacher ratings of attention and hyperactivity.

Two groups of children, one with good attention and low hyperactivity and the other with poor attention and high hyperactivity, were formed on the basis of teachers' ratings. The groups were tested on a large number of tests of attentional performance, covering selective attention, divided attention, sustained attention and executive function. Analysis of group differences, with verbal and non-verbal intelligence controlled statistically, indicated that the groups demonstrated significant differences on a variety of measures. Principal components analysis of the tests of attention isolated two components, one of which significantly distinguished the two groups. It is suggested that this component reflected aspects of executive control of attention. The measures which discriminated the groups most clearly were efficiency of visual search involving two targets in alternation, the number of correct responses on a specially devised version of the Wisconsin Card Sorting Task and a task measuring the ability to inhibit a dominant response. It is suggested that all these tasks required a combination of selective attention and executive control. It was also noted that the poor attention group produced bigger individual differences on all measures, indicating that this group may include a variety of weaknesses which require more precise analysis to distinguish them.

Journal Article↗
PubMedDate not supplied

Obesity and diabetes.

Obesity increases the risk of developing type 2 diabetes. Jacqueline Cleator and John Wilding describe treatment strategies including diet, activity, pharmacotherapy and surgery. They argue that nurses need to gain a greater understanding of nutritional management and behavioural psychology in order to contribute effectively to treatment.

Diabetes Mellitus↗