Biomedical subjects

Jolanta Kedzierska

Publications and source records attributed to Jolanta Kedzierska.

4 recordsLinked to original sources

PubMed2005

[Alcaligenes xylosoxidans--a pathogen of chronic ear infection].

INTRODUCTION: We discuss a case of a 48-year old man admitted to our Department with symptoms of chronic ear infection, that didn't answer to typical conservative treatment. The culture of the discharge was positive for Alcaligenes xylosoxidans. MATERIAL AND METHODS: We report characteristic features of that bacteria and we compare them with features of other pathogens typical for otitis media. We present performed treatment too. RESULTS: Alcaligenes xylosoxidans is a nonfermenting gram-negative rod. It can be confused with other nonfermentive, gram-negative rods, especially Pseudomonas species, in clinical specimens so that its role as a significant pathogen may be underestimated. Alcaligenes xylosoxidans is a part of normal human flora, especially skin and gastrointestinal tract, and can cause serious infections in human (especially in patients with immunodeficiency and premature children). CONCLUSIONS: Reports about Alcaligenes xylosoxidans as a cause of chronic otitis media are very rare and it can be supposed to stay a new kind of ear infection.

Achromobacter denitrificans↗

PubMed2005

[Correlation between computed tomography and microbiological results in chronic sinusitis].

This article presents the observed correlation between the advancement of inflammatory lesions in paranasal sinuses found on computed tomography and microbiological specimen results in chronic sinusitis. The examined study group consisted of 28 patients, aged 19-59 years, in whom endoscopic sinus surgery was performed. In each patient prior to planned surgery a sinus CT scan was performed the result of which was scored using the Lund-Mackay scale, bacteriological and mycological examinations of nasal mucous secretion were also performed. In the study group a positive correlation between the CT score point sum and the number of pathogen species (regression test: r = 0.46; p = 0.0141) was found. With each additional pathogen species found the CT grading rose by 2.3 points. We also found that in patients with positive bacterial culture the average CT score rose by 4.4 (ANOVA: F(1,23)= 3.69; p = 0.0333). However no rise was found in the case of fungi and no interaction between bacteria and fungi was found. In cases of advanced sinusitis where a high CT lesion score of is found antimicrobial therapy based on exact microbiological diagnostics should be given in the perioperative period.

Adult↗

PubMed2003

[Infections with Van B phenotype Enterococcus faecium and E. faecalis in patients with immune deficiency during the course of hematologic neoplasms].

In this work, we have analyzed the second outbreak of VRE with the VanB phenotype to be identified in the country. The aim of this study was to characteristics of the types of resistance to glycopeptide antibiotic and to check the resistance patterns of these pathogens. A trial of monitoring the risk factors for colonization or infection with VRE as well as epidemiological investigation were undertaken. Genus identification of the isolates was performed according to the method of Facklam and Collins, and species were identified using the API 20 Strep test. MICs of different antimicrobial agents were determined by the E-test method. The isolates collected during the investigation demonstrated resistance to multiple antimicrobials, which is a common characteristic of VRE. Isolates were found to be uniformly resistant to penicillin, fluoroquinolones, tetracycline and to high concentrations of aminoglycosides. The only drugs with in vitro activity against the isolates were ampicillin (VRES), linezolid (VRES, VREM) and quinupristin-dalfopristin (VREM). Except for a single VREM isolate, they all revealed the typical VanB phenotype with resistance to vancomycin and susceptibility to teicoplanin. One of the VREM isolates turned out to be resistant to teicoplanin, which coincided with the use of this antibiotic in the patient's therapy. Its vanB gene variant differed by a single mutation from that found in other isolates; however, it also lacked a large part of the vanB gene claster, including the regulatory genes vanRB and -SB, and the vancomycin--inducible promoter PYB. Our studies have found an association between colonization or infection with VRE and the mean duration of hospital stay, previously administration of glycopeptide, cephalosporins and imipenem. These organisms were a common cause of monoethiological bloodstream infections.

Adult↗

PubMed2003

[Bacterial and fungal bloodstream infections in patients at the University Hospital of Cracow].

In presented material evaluation of changes in sepsis and types of bloodstream infections of hospitalized patients in Wards of the University Hospital in Cracow were examined. Results of 9,138 blood cultures studied in years 1989-1999 were analysed. All of the blood samples were recovered from 4,656 infected adults at Clinics of the University Hospital in Cracow. Microbiological blood examinations were held in system of constant monitoring of isolated cultures applying BacT/Alert--colorimetric system (Organon Teknika). Cultured micro--organisms were identified using commercial biochemical tests (bio-Merieux). During period of research changes of profile of isolated microorganisms was observed. Percentage of blood infections of Enterococcus spp. etiology increased from 2.2% in 1989 to 9.8% in 1997-98 (p = 0.014). Dynamic growth of non-fermentative S. maltophilia bacilli to 5.5% (p = 0.036) and Serratia marcescens to 13.8% (p = 0.042) in 1999 was revealed. Designed according to our research review of fungal flora in years 1989-1999 revealed tendency of systematic growth of invasive candidemia frequency, from 1.1% to 10.4%. Diagnostic and therapeutic profile of Departments was in a strict connection with increase of the number and meaning of the politiological bacteremias (p = 0.036) in total number of systemic infections cases.

Adult↗