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Jon Erickson

Publications and source records attributed to Jon Erickson.

5 recordsLinked to original sources
PubMed2006

Collaborative environmental planning in river management: an application of multicriteria decision analysis in the White River Watershed in Vermont.

Multicriteria decision analysis (MCDA) provides a well-established family of decision tools to aid stakeholder groups in arriving at collective decisions. MCDA can also function as a framework for the social learning process, serving as an educational aid in decision problems characterized by a high level of public participation. In this paper, the framework and results of a structured decision process using the outranking MCDA methodology preference ranking organization method of enrichment evaluation (PROMETHEE) are presented. PROMETHEE is used to frame multi-stakeholder discussions of river management alternatives for the Upper White River of Central Vermont, in the northeastern United States. Stakeholders met over 10 months to create a shared vision of an ideal river and its services to communities, develop a list of criteria by which to evaluate river management alternatives, and elicit preferences to rank and compare individual and group preferences. The MCDA procedure helped to frame a group process that made stakeholder preferences explicit and substantive discussions about long-term river management possible.

Community Participation↗
PubMed2005

Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.

The synthesis of novel macrocyclic peptidomimetic inhibitors of the enzyme BACE1 is described. These macrocycles are derived from a hydroxyethylene core structure. Compound 7 was co-crystallized with BACE1 and the X-ray structure of the complex elucidated at 1.6 Angstrom resolution. This molecule inhibits the production of the Abeta peptide in HEK293 cells overexpressing APP751sw.

Alzheimer Disease↗
PubMed2004

P3 cap modified Phe*-Ala series BACE inhibitors.

With the aim of reducing molecular weight and adjusting log D value of BACE inhibitors to more favorable range for BBB penetration and better bioavailability, we synthesized and evaluated several series of P3 cap modified BACE inhibitors obtained via replacement of the P3NHBoc moiety as seen in 3 with other polar functional groups such as amino, hydroxyl and fluorine. Several promising inhibitors emerging from this P3 cap SAR study (e.g., 15 and 19) demonstrated good enzyme inhibitory potencies (BACE-1 IC(50) <50 nM) and whole cell activities (IC(50) approximately 1 microM).

Amyloid Precursor Protein Secretases↗
PubMed2004

Molecular properties that influence oral drug-like behavior.

Pharmaceutical companies are constantly racing to discover the next therapeutic blockbuster. The consensus in the industry is to focus on compounds that are by some measure drug-like, but in order to do this effectively a number of questions must be answered. For example, how should drug-like be defined and how might this definition be used to enhance drug discovery? Has the field moved beyond Lipinski's seminal 'rule-of-five' observations? This review offers a working definition of oral drug-likeness, describes various approaches used in its characterization and discusses its appropriate use. We will focus primarily on the use of computed molecular properties that attempt to predict the oral drug-like behavior of compounds and propose guidelines for the use of observations and trends established in existing datasets to support drug discovery efforts. In particular, this review will demonstrate how trends in simple properties of the data can be used prospectively to compare and prioritize groups of compounds, chemical libraries and different chemical series with greater reliability than for predicting drug-likeness of single compounds. It is the authors' belief, however, that properties or descriptors that will completely separate drug-like space from non-drug-like space are unlikely to be found; the focus should instead lie on overall distributions of drug-like and non-drug-like compounds in the property space that tend to overlap significantly.

Administration, Oral↗