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Jon S Thompson

Publications and source records attributed to Jon S Thompson.

20 records · Page 2Linked to original sources

Identification and management of an errant antiperistaltic Roux limb after total gastrectomy.

We recently evaluated two patients because of persistent, unexplained bilious vomiting following total gastrectomy with Roux-en-Y esophagojejunostomy. With the aid of intestinal manometry and reoperation, an antiperistaltic Roux limb was discovered in both cases. Isoperistaltic repositioning of the Roux limb led to resolution of both patients' symptoms. These case reports illustrate the devastating consequences of a poorly constructed Roux-en-Y esophagojejunostomy and demonstrate the utility of intestinal manometry in aiding the diagnosis of problems related to the Roux limb, particularly when surgical reexploration is not preferred or is inconclusive. By highlighting this avoidable technical error, we hope to prevent its future occurrence.

Adult↗

Wound matrix attachment regulates actin content and organization in cells of the granulation tissue.

Actin cytoskeletal polymerization is associated with a pro-proliferative, pro-survival state. We hypothesized that the actin polymerization of wound cells is increased in the presence of wound matrix attachment and is decreased after disruption of this attachment. Musculocutaneous flap and wound splinting models were used to investigate the effect of wound matrix attachment on the actin cytoskeleton. Disruption of wound matrix attachment was accomplished by incision of the wound matrix/dermis interface (wound matrix release) and/or desplinting. Polymerized actin was assayed with phalloidin labeling of wound specimens 24 hours after disruption of attachment and a method to quantify the content and organization of polymerized actin in granulation tissue was used. Disruption of wound matrix attachment decreased the content of polymerized actin, the actin staining intensity, and the actin fiber organization in the granulation tissue of both the flap and splint models. Disruption of wound matrix attachment decreased actin polymerization and fiber organization in the granulation tissue. Our data support the concept that the state of wound matrix attachment regulates the actin cytoskeleton of wound cells.

Actins↗