Biomedical subjects

Jonathan D Victor

Publications and source records attributed to Jonathan D Victor.

15 recordsLinked to original sources

PubMed2005

Interaction of luminance and higher-order statistics in texture discrimination.

Most studies of texture processing are based on textures in which individual pixel statistics are varied and spatial correlations are absent ("IID textures"), or textures in which spatial correlation structure is varied and luminance, or first-order, statistics are held constant. Here we jointly examine simple pixel statistics and fourth-order spatial correlation structure along the continuum of "even" and "odd" isodipole textures of Julesz, Gilbert and Victor [Julesz, B., Gilbert, E.N., & Victor, J.D. (1978). Biological Cybernetics, 31(3) 137-140], as well as their interactions. Absolute efficiency to detect either kind of statistical cue is low: approximately 0.05 for luminance statistics, and 0.004 for isodipole statistics. Above threshold, isodipole statistics must change by approximately four times the amount that pixel statistics must change to generate an equally salient texture. When pixel statistics and isodipole statistics are simultaneously varied, the two texture cues combine by probability summation and perceptual distances are approximately Euclidean. Superimposed on this picture are subtle foreground/background asymmetries that suggest properties of the visual mechanisms that are sensitive to these image statistics.

Adult↗

PubMed2005

Binocular depth perception from unpaired image points need not depend on scene organization.

Dichoptic stimuli containing unmatched features can produce depth perception despite the absence of binocular disparity, a phenomenon known as da Vinci stereopsis. Unmatched points can arise from depth discontinuities and partial occlusion in the real world. It has been hypothesized that spatial organization of unmatched image features as dictated by the ecological optics of occlusion might determine perceived depth in da Vinci stereopsis. We tested this hypothesis by creating dichoptic stimuli containing unmatched points in which local cues and overall organization could be dissociated. For these stimuli, observers' perception of depth did not depend on the organization of the scene, but only on the local cues. This finding shows the perceived depth of unpaired points need not depend on reconstructing the spatial organization of depth discontinuities in real-world scenes.

Depth Perception↗

PubMed2004

Local processes and spatial pooling in texture and symmetry detection.

We examined the ability of human observers to detect three kinds of statistical structure in binary arrays: first-order statistics (luminance), local fourth-order statistics (isodipole textures), and long-range statistics (bilateral symmetry). Performance was closest to ideal on the luminance task and furthest from ideal on the symmetry task. For each kind of statistic, the dependence of performance on the degree of structure was well described by a model consisting of an initial stage of multiple independent detectors, followed by a pooling stage. For the luminance task and the isodipole task, performance was well-modeled by local processing followed by extensive spatial pooling. For the symmetry task, limitations at the local detection stage and a near-absence of spatial pooling were needed to model for performance.

Adult↗

PubMed2004

Non-Euclidean properties of spike train metric spaces.

Quantifying the dissimilarity (or distance) between two sequences is essential to the study of action potential (spike) trains in neuroscience and genetic sequences in molecular biology. In neuroscience, traditional methods for sequence comparisons rely on techniques appropriate for multivariate data, which typically assume that the space of sequences is intrinsically Euclidean. More recently, metrics that do not make this assumption have been introduced for comparison of neural activity patterns. These metrics have a formal resemblance to those used in the comparison of genetic sequences. Yet the relationship between such metrics and the traditional Euclidean distances has remained unclear. We show, both analytically and computationally, that the geometries associated with metric spaces of event sequences are intrinsically non-Euclidean. Our results demonstrate that metric spaces enrich the study of neural activity patterns, since accounting for perceptual spaces requires a non-Euclidean geometry.

Action Potentials↗

PubMed2004

Visual working memory for image statistics.

To define the role of statistical features of images in visual working memory, we compared the ability of subjects (N=6) to identify changes in arrays of black and white checks when these changes altered some aspect of their statistical structure, versus when these changes did not. Alteration of luminance statistics or local higher-order statistics improved performance, but alteration of the degree of bilateral symmetry did not. The dependence of performance on the degree of statistical change indicated that statistical information was represented in a graded, rather than categorical, fashion.

Adult↗

PubMed2004

Relationship of petrous temporal bone pneumatization to the eustachian tube lumen.

OBJECTIVES/HYPOTHESIS: Objectives were to determine the incidence of petrous apex pneumatization and to define the relationship between a pneumatized petrous temporal bone and the eustachian tube lumen. STUDY DESIGN: Retrospective study with institutional review board approval including only adult patients. METHODS: One hundred head computed tomography (ct) scans and 204 petrous temporal bone CT scans performed at a tertiary teaching hospital were reviewed. The two senior authors (s.h.s., p.c.s.) independently reviewed the petrous temporal bone CT scans for grade of pneumatization. Pneumatized CT scans were then reviewed for the presence of a direct communication with the eustachian tube lumen. Significance was determined using the chi test and Pearson correlation of ranks. RESULTS: The incidence of peritubal cells opening into the eustachian tube anterior to the tympanic orifice was 92%. CONCLUSION: The direct communication of peritubal cells with the bony eustachian tube may play a role in the development of persistent cerebrospinal fluid rhinorrhea after cerebellopontine angle surgery.

Adult↗

PubMed2003

Comparison of conscious sedation and general anesthesia for motor mapping and resection of tumors located near motor cortex.

OBJECT: The surgical treatment of tumors located near eloquent cortex carries a high risk of inducing worsening neurological deficits. Intraoperative electrocorticography techniques have been developed to help identify these areas at the time of surgery in an effort to minimize such risks. The optimal anesthetic technique for conducting these procedures, however, has never been determined. METHODS: The authors conducted a retrospective study to compare patients who underwent intraoperative motor mapping between September 2000 and May 2002. Demographic and neurophysiological monitoring data were collected from the hospital records. Patients were divided into two groups based on the anesthetic technique used for surgery: in Group 1 general anesthesia was used, and in Group 2 conscious sedation. Group 1 comprised 24 patients (mean age 47 years) with 16 right- and eight left-sided lesions. Group 2 consisted of 21 patients (mean age 46 years) with 18 right- and three left-sided lesions. Pathological diagnoses were similar between the two groups. Motor stimulation was elicited in 12 patients (50%) in Group 1 and in 21 patients (100%) in Group 2 (p < 0.001). In addition, the mean stimulation amplitude required was significantly higher (13 mA) in patients in whom conscious sedation was used as opposed to general anesthesia (5 mA, p < 0.0001). Electrographic evidence of seizures was seen in 29% of Group 1 compared with 10% of Group 2 patients (p > 0.05). CONCLUSIONS: The use of conscious sedation as an anesthetic technique for motor mapping not only improves the chances of achieving successful stimulation and identification of motor cortex in relationship to the lesion, but it also allows for repetitive monitoring of the patient's motor function during resection of the lesion.

Adenocarcinoma↗

PubMed2003

Neural coding of spatial phase in V1 of the macaque monkey.

We examine the responses of single neurons and pairs of neurons, simultaneously recorded with a single tetrode in the primary visual cortex of the anesthetized macaque monkey, to transient presentations of stationary gratings of varying spatial phase. Such simultaneously recorded neurons tended to have similar tuning to the phase of the grating. To determine the response features that reliably discriminate these stimuli, we use the metric-space approach extended to pairs of neurons. We find that paying attention to the times of individual spikes, at a resolution of approximately 30 ms, and keeping track of which neuron fires which spike rather than just the summed local activity contribute substantially to phase coding. The contribution is both quantitative (increasing the fidelity of phase coding) and qualitative (enabling a 2-dimensional "response space" that corresponds to the spatial phase cycle). We use a novel approach, the extraction of "temporal profiles" from the metric space analysis, to interpret and compare temporal coding across neurons. Temporal profiles were remarkably consistent across a large subset of neurons. This consistency indicates that simple mechanisms (e.g., comparing the size of the transient and sustained components of the response) allow the temporal contribution to phase coding to be decoded.

Action Potentials↗

PubMed2003

Role of hyperpolarization-activated currents for the intrinsic dynamics of isolated retinal neurons.

The intrinsic dynamics of bipolar cells and rod photoreceptors isolated from tiger salamanders were studied by a patch-clamp technique combined with estimation of effective impulse responses across a range of mean membrane voltages. An increase in external K(+) reduces the gain and speeds the response in bipolar cells near and below resting potential. High external K(+) enhances the inward rectification of membrane potential, an effect mediated by a fast, hyperpolarization-activated, inwardly rectifying potassium current (K(IR)). External Cs(+) suppresses the inward-rectifying effect of external K(+). The reversal potential of the current, estimated by a novel method from a family of impulse responses below resting potential, indicates a channel that is permeable predominantly to K(+). Its permeability to Na(+), estimated from Goldman-Hodgkin-Katz voltage equation, was negligible. Whereas the activation of the delayed-rectifier K(+) current causes bandpass behavior (i.e., undershoots in the impulse responses) in bipolar cells, activation of the K(IR) current does not. In contrast, a slow hyperpolarization-activated current (I(h)) in rod photoreceptors leads to pronounced, slow undershoots near resting potential. Differences in the kinetics and ion selectivity of hyperpolarization-activated currents in bipolar cells (K(IR)) and in rod photoreceptors (I(h)) confer different dynamical behavior onto the two types of neurons.

Animals↗

PubMed2003

Reading a population code: a multi-scale neural model for representing binocular disparity.

Although binocular neurons in the primary visual cortex are sensitive to retinal disparity, their activity does not constitute an unambiguous disparity signal. A multi-spatial-scale neural model for disparity computation is developed to examine how population activity might be interpreted to overcome ambiguities at the single neuron level. The model incorporates a front end that encodes disparity by a family of complex cell-like energy units and a second stage that reads the population activity. Disparity is recovered by matching the population response to a set of canonical templates, derived from the mean response to white noise stimuli at a range of disparities. Model predictions are qualitatively consistent with a variety of psychophysical results in the literature, including the effects of spatial frequency on stereoacuity and bias in perceived depths, and the effect of standing disparity on increment thresholds. Model predictions are also consistent with data on qualitative appearance of complex stimuli, including depth averaging, transparency, and corrugation. The model also accounts for the non-linear interaction of disparities in compound grating stimuli. These results show that a template-match approach reduces ambiguities in individual and pooled neuronal responses, and allows for a broader range of percepts, consistent with psychophysics, than other models. Thus, the pattern of neural population activity across spatial scales is a better candidate for the neural correlate of depth perception than the activity of single neurons or the pooled activity of multiple neurons.

Depth Perception↗

PubMed2003

Taste response variability and temporal coding in the nucleus of the solitary tract of the rat.

Theories of taste coding in the brain stem have been based on the idea that taste responses are integrated over time without regard to the temporal structure of the taste-evoked spike train. In the present experiment, the reliability of response rate across stimulus repetitions and the potential contribution of temporal coding to the discrimination of taste stimuli was examined. Taste stimuli representing the four basic taste qualities were presented repeatedly, and electrophysiological responses were recorded from single cells in the nucleus of the solitary tract (NTS) of anesthetized rats. Blocks of the four tastants were repeated for as long as the cell remained isolated. Nineteen cells were recorded with between 8 and 27 repetitions of each stimulus. Response magnitude to a given tastant varied widely within some NTS cells. This impacted the determination of both the breadth of tuning and best stimulus for a given cell. The contribution of spike timing and the pattern of interspike intervals to discrimination of taste stimuli was evaluated by an information-theoretic approach based on two families of metrics. Spike timing significantly contributed to the discrimination of taste qualities in 10 of 19 (53%) cells. This contribution was especially notable during the initial 2 s of the response. Those cells that showed the most variable firing rates in response to repetition of taste stimuli tended to show the largest contribution of temporal coding. These results suggest that, in addition to response rate, the temporal parameters of responses may convey information about taste stimuli in the NTS.

Action Potentials↗

PubMed2002

Binless strategies for estimation of information from neural data.

We present an approach to estimate information carried by experimentally observed neural spike trains elicited by known stimuli. This approach makes use of an embedding of the observed spike trains into a set of vector spaces, and entropy estimates based on the nearest-neighbor Euclidean distances within these vector spaces [L. F. Kozachenko and N. N. Leonenko, Probl. Peredachi Inf. 23, 9 (1987)]. Using numerical examples, we show that this approach can be dramatically more efficient than standard bin-based approaches such as the "direct" method [S. P. Strong, R. Koberle, R. R. de Ruyter van Steveninck, and W. Bialek, Phys. Rev. Lett. 80, 197 (1998)] for amounts of data typically available from laboratory experiments.

Action Potentials↗

PubMed2002

Detection and discrimination of relative spatial phase by V1 neurons.

Edge-like and line-like features result from spatial phase congruence, the local phase agreement between harmonic components of a spatial waveform. Psychophysical observations and models of early visual processing suggest that human visual feature detectors are specialized for edge-like and line-like phase congruence. To test whether primary visual cortex (V1) neurons account for such specificity, we made tetrode recordings in anesthetized macaque monkeys. Stimuli were drifting equal-energy compound gratings composed of four sinusoidal components. Eight congruence phases (one-dimensional features) were tested, including line-like and edge-like waveforms. Many of the 137 single V1 neurons (recorded at 45 sites) could reliably signal phase congruence by any of several response measures. Across neurons, the preferred spatial feature had only a modest bias for line-like waveforms. Information-theoretic analysis showed that congruence phase was temporally encoded in the frequency band present in the stimuli. The most sensitive neurons had feature discrimination thresholds that approached psychophysical levels, but typical neurons were substantially less sensitive. In single V1 neurons, feature discrimination exhibited various dependences on the congruence phase of the reference waveform. Simple cells were over-represented among the most sensitive neurons and on average carried twice as much feature information as complex cells. However, the distribution of the indices of optimal tuning and discrimination of relative phase was indistinguishable in simple and complex cells. Our results suggest that phase-sensitive pooling of responses is required to account for human psychophysical performance, although variation in feature selectivity among nearby neurons is considerable.

Action Potentials↗

PubMed2002

Temporal phase discrimination depends critically on separation.

Temporal phase discrimination was measured as a function of spatial separation of the stimulus components. In contrast to many previous studies, phase discrimination thresholds were measured directly, rather than inferred from the ability to discriminate synchronous from antiphase stimuli, or from segregation or shape tasks. For abutting bars, relative phase thresholds were closely proportional to temporal frequency. The proportionality corresponded to a threshold temporal offset of 2.5-9.5 ms, across subjects. Introduction of a small gap (0.125 degrees or greater) led to a dramatic (3- to 7-fold) increase in thresholds for temporal phase discrimination, and thresholds were no longer proportional to temporal frequency. Insertion of a third bar filling the gap resulted in a recovery of the low thresholds, provided that its modulation was consistent with apparent motion across the three bars. Below 8 Hz, phase discrimination thresholds across three bars were equivalent to thresholds for two abutting bars. Above 8 Hz, phase discrimination thresholds for the three bar combination were lower than thresholds for two adjacent bars, implying that phase information was integrated across all three bars.Phase discrimination thresholds do not appear to reflect the properties of a single mechanism. Especially at high temporal frequencies, low thresholds for phase discrimination are closely tied to the presence of apparent motion. Temporal phase discrimination is markedly impaired by a small separation of stimulus components. Moreover, the inability to detect phase differences across gaps corresponds to the loss of phase-dependence of vernier acuity thresholds across gaps.

Adult↗

PubMedDate not supplied

Relation between potassium-channel kinetics and the intrinsic dynamics in isolated retinal bipolar cells.

Characterization of the intrinsic dynamics of isolated retinal bipolar cells by a whole-cell patch-clamp technique combined with estimation of effective impulse responses across a range of mean injected currents reveals strikingly adaptive behavior. At resting potential, bipolar cells' effective impulse response is slow, high gain, and low pass. Depolarization speeds up response, decreases gain, and, in most cells, induces bandpass behavior. This adaptive behavior involves two K(+) currents. The delayed-rectifier accounts for the observed gain reduction, speed increase, and bandpass behavior. The A-channel further shortens the impulse responses but suppresses bandpass features. Computer simulations of model neurons with a delayed-rectifier and varying A-channel conductances reveal that impulse responses largely reflect the flux of electrical charge through the two K(+) channels. The A-channel broadens the frequency response and preempts the action of the delayed-rectifier, thereby reducing the associated bandpass features. Admixtures of the two K(+) channels produce the observed variety of dynamics of retinal bipolar cells.

4-Aminopyridine↗