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Biomedical subjects

Jorge H Mestman

Publications and source records attributed to Jorge H Mestman.

4 recordsLinked to original sources
PubMed2005

Prevention of T2DM in women with a previous history of GDM.

Women with a history of gestational diabetes mellitus (GDM) have a high risk of progression to type 2 diabetes mellitus (T2DM). Risk factors are similar for GDM and T2DM and include, among others, obesity, family history, and ethnic background. GDM is also associated with the metabolic syndrome. Women with impaired glucose tolerance or "prediabetes" postpartum have the highest risk of progression. In women with impaired glucose tolerance, lifestyle modification or pharmacologic therapy may prevent or delay the onset of T2DM.

Blood Glucose↗
PubMed2004

Hyperthyroidism in pregnancy.

Graves' disease may complicate the course of pregnancy; pregnancy on the other hand may alter the natural course of the disease. It is imperative for women of childbearing age affected by the disease to be informed about the potential maternal and fetal problems if the condition is not properly managed. Preconception control in women with diabetes has resulted in a dramatic decrease in the number of perinatal complications. The same approach should be encouraged for women with thyroid diseases. Ideally, the women suffering from hyperthyroidism or any other thyroid disease should be metabolically compensated at time of conception-the need for contraception until the disease is controlled should be openly discussed. A multidisciplinary approach by a health care team is of paramount importance during pregnancy, with the involvement of the obstetrician, perinatologist, endocrinologist, neonatologist, pediatrician and anesthesiologist. In many situations the assistance of social workers, nutritionists, and other health care professionals may be needed. The future mother and her family should be aware of the potential complications for both mother and her offspring if proper management guidelines are not carefully followed.

Antithyroid Agents↗
PubMed2003

Intractable hyperemesis gravidarum, transient hyperthyroidism and intrauterine growth restriction associated with hyperreactio luteinalis. A case report.

BACKGROUND: Hyperreactio luteinalis represents benign pregnancy-associated ovarian enlargement caused by multiple theca-lutein cysts. It is usually discovered incidentally at the time of ultrasound, cesarean section or postpartum tubal ligation with the majority of cases asymptomatic. CASE: A 30-year-old, nulliparous, West African woman initially presented with hyperemesis gravidarum at 8 weeks' gestation. Bilateral, 10-cm theca-lutein cysts were discovered on ultrasound at 27 weeks. Despite intravenous hyperalimentation, the patient continued to have intractable vomiting and transient episodes of hyperthyroidism. She delivered a 1,450-g, female infant at 33 weeks; findings at the time of cesarean delivery included bilateral 10 x 8-cm theca-lutein cysts. Laboratory evaluation confirmed clinical evidence of virilization, with markedly elevated levels of testosterone and androstenedione. CONCLUSION: Intractable hyperemesis gravidarum, transient hyperthyroidism and intrauterine growth restriction may be associated with hyperreactio luteinalis.

Adult↗