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Biomedical subjects

Jorge L Sánchez

Publications and source records attributed to Jorge L Sánchez.

15 recordsLinked to original sources
PubMed2005

Bullous solar elastosis.

Solar elastosis is a recognized manifestation of chronic sun exposure affecting mainly Caucasian skin. Recognizable clinical manifestations of solar elastosis include cutis rhomboidalis nuchae, Favre-Racouchot syndrome, actinic comedonal plaque, nodular forms such as elastomas, elastic nodule of the ear and elastotic bands, collagenous plaques of the hand, and colloid milia. We report two patients with an unusual presentation of vesicular lesions clinically and histopathologically situated in zones of severe solar elastosis that has been previously referred to as bullous solar elastosis.

Aged↗
PubMed2004

Persistent blue nevus simulating melanoma.

We report a case of a persistent blue nevus that significantly extended beyond the scar of the original excision mimicking those clinical changes usually seen in melanoma. The histopathologic evaluation revealed a common blue nevus. The lesion was re-excised, and 10 months later a bluish macule appeared next to the surgical scar. This case of a persistent blue nevus with an unusual clinical presentation and a benign clinical course highlights the fact that the clinical markers commonly used to identify melanoma in pigmented lesions will not always accurately diagnose melanoma.

Adolescent↗
PubMed2004

Angiolymphoid hyperplasia with eosinophilia associated to a squamous cell carcinoma of the ear.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign vascular proliferation that usually affects the head and neck region. METHOD: An 89-year-old man who had a squamous cell carcinoma on the posterior aspect of one ear developed lesions of angiolymphoid hyperplasia with eosinophilia on the anterior aspect of the same ear. RESULTS: After surgical treatment of the malignant neoplasm, the lesions of angiolymphoid hyperplasia with eosinophilia disappeared spontaneously. CONCLUSIONS: Damage to the vasculature of the ear by the malignant neoplasm or the release of angiogenic factors by the same neoplasm is a plausible explanation for the development and eventual resolution of the vascular proliferation.

Aged↗
PubMed2004

Successful treatment of persistent melanoma in situ with 5% imiquimod cream.

BACKGROUND: Five percent imiquimod cream, a topically applied immune response modifier with potent antiviral and antitumor activity, has been reported to be effective in the management of lentigo maligna and cutaneous metastases from melanoma. OBJECTIVE: We report a case in which 5% imiquimod cream was effective in the management of a persistent melanoma in situ. METHODS: Five percent imiquimod cream was applied to the affected area twice to three times a week, as tolerated. RESULTS: After 4 months of treatment, repeated biopsies of the previously affected areas showed complete regression of the melanoma. CONCLUSION: Treatment of melanoma in situ of sun-damaged areas with 5% imiquimod cream certainly appears warranted in selected cases where surgical procedures have failed or are not feasible owing to factors such as size and/or localization of the lesion, advanced age, or deteriorated medical status of the patient. Rigorous posttreatment follow-up is mandatory, because long-term recurrence rates after treatment of melanoma in situ with imiquimod are yet unknown.

Administration, Cutaneous↗
PubMed2003

Prevalence of skin disease in HIV-positive pregnant women.

BACKGROUND: The rate of human immunodeficiency virus (HIV) infection in women of reproductive age has increased dramatically in the last decade. The effects of pregnancy on the prevalence of cutaneous diseases in this group is unclear. OBJECTIVES: To compare the prevalence of cutaneous diseases in healthy pregnant women, HIV-positive pregnant women, and HIV-positive nonpregnant women. METHODS: Fifty HIV-positive pregnant women and 52 HIV-positive nonpregnant women were compared with a control group of 50 HIV-negative pregnant women for the prevalence of cutaneous diseases. RESULTS: The prevalence of cutaneous diseases was higher (65%) in the HIV-positive nonpregnant group than in the HIV-positive pregnant group (42%) or the control group (28%). Infectious diseases were more frequent in the HIV-positive nonpregnant group. CONCLUSIONS: Pregnancy does not seem to increase the prevalence of cutaneous diseases that occur during the course of HIV disease.

Adult↗
PubMed2003

Angiosarcoma of the face resembling rhinophyma.

We report the case of a 69-year-old man who had a persistent lesion develop on his nose during a 1-year period of time that was diagnosed as rhinophyma. Despite laser treatment the lesion continued to grow. Histopathology and immunohistochemical studies were consistent with cutaneous angiosarcoma. Rhinophyma-like features should be considered as an unusual clinical manifestation of cutaneous angiosarcoma.

Aged↗
PubMed2002

Cervical shedding of human T cell lymphotropic virus type I is associated with cervicitis.

Human T cell lymphotropic virus type I (HTLV-I) is sexually transmitted. The purpose of this study was to determine the prevalence and risk factors for cervical shedding of HTLV-I DNA among Peruvian sex workers. HTLV tax DNA was detected in cervical specimens from 43 (68%) of 63 HTLV-I-infected sex workers and in samples obtained during 113 (52%) of 216 clinic visits between 1993 and 1997. Detection of HTLV DNA was associated with the presence of > or =30 polymorphonuclear cells (PMNs) within cervical mucus per 100x microscopic field (odds ratio [OR], 4.3, 95% confidence interval [CI], 1.8-10.1) and with the presence of cervical secretions (OR, 2.0; 95% CI 1.2-3.4). Hormonal contraceptive use (OR 1.7; 95% CI, 0.8-3.6) and concomitant cervical infection by Chlamydia trachomatis (OR, 1.5; 95% CI, 0.3-4.3) or Neisseria gonorrhoeae (OR, 1.1; 95% CI, 0.6-3.7) were not significantly associated with HTLV-I shedding. Our results suggest that cervicitis may increase cervical HTLV-I shedding and the sexual transmission of this virus.

Adult↗
PubMed2002

kDNA markers define two major Trypanosoma rangeli lineages in Latin-America.

Trypanosoma rangeli is a hemoflagellate parasite of man, domestic and wild animals in Central and South America. The genus Rhodnius is particularly susceptible to infection by T. rangeli and transmission by salivary inoculation has been demonstrated in 12 of 14 nominal species of naturally and experimentally infected insects. This report describes the molecular characterization of 37 strains of T. rangeli isolated from vertebrate and invertebrate hosts. Strains were analyzed by hybridization with kinetoplast DNA (kDNA) probes, polymerase chain reaction (PCR) amplification of kDNA minicircles and random amplification polymorphic DNA (RAPD). Strains isolated from Rhodnius prolixus present KP1, KP2 and KP3 minicircle amplification products but strains isolated from R. colombiensis or Panstrongylus megistus present amplification products derived only from KP2 and KP3 minicircles. The two T. rangeli groups defined as KP1(+) and KP1(-) present a high genetic divergence as they have probably been co-evolutioned with different adaptive radiated lines of the genus Rhodnius in Latin-America. The data obtained from insects with intestinal and salivary glands infections confirm that each Rhodnius species select the sub-population of T. rangeli KP1(+) or KP1(-) which is susceptible to transmit it by salivary inoculation to the vertebrate host.

Animals↗
PubMedDate not supplied

Bullous pemphigoid: course of the disease. A study of 25 patients.

Different studies on the course of bullous pemphigoid have suggested that there may be significant variations in the survival of these patients based on their ethnicity or region of origin. Because of the lack of studies on patients with bullous pemphigoid in the Caribbean, specifically in Puerto Rico, a retrospective analysis about the outcome of patients with this disease in the region was performed. Twenty-five (25) patients were included in this study. The patients were diagnosed as bullous pemphigoid by clinical, histopathologic and immunopathologic assessment. Medical records were reviewed and those patients that were alive were contacted and examined on a follow up visit. Nine were men and sixteen were women; the age at the time of the diagnosis ranged from 54 to 90 year-old (mean 72); 13 were alive after at least 5 years of follow-up and 12 had died. The age at the moment of death ranged from 67 to 95 year-old (mean 83). Of those patients living, 85% were in remission, while 15% had active disease. In general, patients had a disease of mild severity, but, still, 68% of them received systemic corticosteroid therapy. Five of patients had to be admitted due to disease; two of them died while at the hospital. This data suggests that bullous pemphigoid in Puerto Ricans is a disease with a relatively benign course, but which can be fatal in the elderly, especially, if it requires admission to the hospital and the patient receives high doses of systemic corticosteroids.

Aged↗
PubMedDate not supplied

Pigmented mammary Paget's disease in a man.

Mammary Paget's disease is one clinical expression of an underlying breast carcinoma. It manifests as persistent erythema, oozing and scaling of the nipple, areola or both. The occurrence of this disease in men is uncommon. This is a report of a pigmented lesion of Paget's disease occurring on the breast of a man. This presentation is unusual and may be confused with melanoma. Its early recognition is important so that adequate therapy may be instituted when the disease has a favorable prognosis.

Aged↗
PubMedDate not supplied

Extranodal B-cell lymphoma in a patient with atopic-like dermatitis.

Atopic dermatitis is a chronic relapsing skin disease that occurs commonly during early infancy and childhood and is frequently associated to personal and family history of allergic rhinitis, asthma and/or skin disease. As a rule, it follows a benign course. We report a case of a female patient with a chronic atopic-like dermatitis who eventually developed an extranodal systemic large B-cell lymphoma during the course of her disease.

Adult↗