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Biomedical subjects

José Pardo

Publications and source records attributed to José Pardo.

10 recordsLinked to original sources
PubMed2005

[Nail disorders from epothilone].

We present the cases of two patients diagnosed with non-microcytic lung carcinoma who were treated with epothilone, a new chemotherapeutic agent which disrupts microtubule dynamics. The first one developed nail symptoms consisting of painful nails with a hemorrhagic appearance, which developed into significant structural disorders and onycholysis of all of the fingernails. The patient required antibiotic treatment for the associated paronychia and surgical removal of some of the nails. In the second case, asymptomatic dyschromia of the toenails appeared, with no inflammatory component. These findings show the similarity of the adverse effects of epothilone with those of the taxanes.

Aged↗
PubMed2005

[Atypical aquagenic keratoderma].

Aquagenic keratoderma is an infrequent condition characterized by the appearance of lesions on the palms of the hands a few minutes after contact with water; these lesions vanish a short time after they dry. Published cases were primarily in adolescent females. We present the case of a male patient with lesions that clinically corresponded to aquagenic keratoderma, except that they were distributed on the backs of both hands and on the anterior face of the wrist. These characteristics had not been described in the literature prior to this case. Previously described cases were reviewed and several differential diagnoses were established, such as rofecoxib-induced palmar lesions, or those appearing in cystic fibrosis.

Adult↗
PubMed2004

Localized bullous pemphigoid overlying a fistula for hemodialysis.

Two cases of bullous pemphigoid exclusively limited to the skin overlying a hemodialysis fistula in patients with chronic renal failure are reported. This is an unusual association, but should be taken into account in the differential diagnosis of bullous disorders among patients on hemodialysis. We hypothesize about the pathogenesis of this process.

Aged↗
PubMed2004

Comparative effect of the fungicide Prochloraz-Mn on Agaricus bisporus vegetative-mycelium and fruit-body cell walls.

Fungicides to control mycopathogens of commercial Agaricus bisporus, a mushroom cultivated for human consumption, are a major field of study, since these chemicals are toxic to both the host and its fungal parasites. The fungicide Prochloraz-Mn, used at its LD50 for A. bisporus, partially inhibited protein biosynthesis in the vegetative mycelial cell walls of this mushroom and caused significant changes in cell-wall polysaccharide structure, as deduced by methylation analysis and gas liquid chromatography-mass spectrometry (GLC-MS). Furthermore, the aggregated mycelial walls showed distinct alterations in their overall chemical composition following the administration of Prochloraz-Mn at the LD50 and the LD50 x1000. As expected, GLC-MS studies indicated that the latter dose caused more appreciable differences in polysaccharide structure. The decrease in mushroom crop yields obtained from industrial cultures treated with Prochloraz-Mn to control V. fungicola infection depended on the dose of the fungicide employed, whereas fruit-body morphology was only slightly affected at the highest Prochloraz-Mn concentration used.

Agaricus↗
PubMed2003

Laparotomy wound recurrence of endometrial carcinoma.

OBJECTIVES: Most endometrial cancer relapses are either pelvic or distant metastases. Recurrences in the laparotomy scar are extremely rare, as to our knowledge this is only the sixth reported case and the first treated with brachytherapy. We also present a review of the literature with an emphasis on radiation therapy treatment. CASE: A 64-year-old woman underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for IIIA endometrial adenocarcinoma, followed by systemic chemotherapy and pelvic external-beam radiotherapy. Three years later, a recurrence in the laparotomy scar was resected and additional chemotherapy was administered. A solitary mass in the abdominal wound was then found 4 years after that and was reirradiated by combining external-beam radiation therapy and interstitial brachytherapy after complete resection. Histology of the abdominal wall implants was very similar to that of the primary tumour. CONCLUSIONS: Laparotomy wound recurrence (LWR) for endometrial cancer usually appears as a solitary mass that grows slowly without concomitant failure sites a few years after hysterectomy. In these six patients there is no common histology pattern that could suggest predictive factors for LWR. Common postoperative irradiation does not deliver sufficient a dose to the anterior abdominal wall to prevent this kind of failure.

Adenocarcinoma↗
PubMedDate not supplied

[Treatment of severe refractory pemphigus vulgaris with rituximab].

Pemphigus vulgaris is a potentially fatal autoimmune bullous disease. High doses of immunosuppressive drugs are used in managing severe cases of pemphigus. Rituximab, an anti-CD20 monoclonal antibody, has proven to be effective in patients with refractory pemphigus vulgaris and pemphigus foliaceus. We review cases of pemphigus vulgaris and pemphigus foliaceus not associated with lymphoma that were treated with rituximab, and we report a new case of severe refractory pemphigus vulgaris successfully treated with rituximab.

Antibodies, Monoclonal↗