Biomedical subjects

Jose A Lozano

Publications and source records attributed to Jose A Lozano.

2 recordsLinked to original sources

PubMed2006

Side chain placement using estimation of distribution algorithms.

OBJECTIVE: This paper presents an algorithm for the solution of the side chain placement problem. METHODS AND MATERIALS: The algorithm combines the application of the Goldstein elimination criterion with the univariate marginal distribution algorithm (UMDA), which stochastically searches the space of possible solutions. The suitability of the algorithm to address the problem is investigated using a set of 425 proteins. RESULTS: For a number of difficult instances where inference algorithms do not converge, it has been shown that UMDA is able to find better structures. CONCLUSIONS: The results obtained show that the algorithm can achieve better structures than those obtained with other state-of-the-art methods like inference-based techniques. Additionally, a theoretical and empirical analysis of the computational cost of the algorithm introduced has been presented.

Algorithms↗

PubMed2006

Bayesian model averaging of naive Bayes for clustering.

This paper considers a Bayesian model-averaging (MA) approach to learn an unsupervised naive Bayes classification model. By using the expectation model-averaging (EMA) algorithm, which is proposed in this paper, a unique naive Bayes model that approximates an MA over selective naive Bayes structures is obtained. This algorithm allows to obtain the parameters for the approximate MA clustering model in the same time complexity needed to learn the maximum-likelihood model with the expectation-maximization algorithm. On the other hand, the proposed method can also be regarded as an approach to an unsupervised feature subset selection due to the fact that the model obtained by the EMA algorithm incorporates information on how dependent every predictive variable is on the cluster variable.

Algorithms↗