Biomedical subjects
Publications and source records attributed to Joseph M Van De Water.
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Clinical parameters alone have repeatedly been proven unreliable in assessing cardiopulmonary status, especially in hemodynamically unstable patients. To learn if we had a diagnostic problem in our hospital, we compared physician assessment of cardiac index (CI) and thoracic fluid content (TFC) to values obtained using impedance cardiography (ICG). We selected the newest available ICG monitor, the BioZ, which employs this noninvasive technology. For CI measurements we have shown it to be equivalent to thermodilution and to be more reproducible (variability: 6.3% vs. 24.7%). Physician assessment of CI and TFC (high, normal, or low) was compared to the BioZ monitor's results in 186 patients, considered to be hemodynamically unstable, from the emergency room, the intensive care units, and the floors. Normal values were defined for CI (2.5-4.2 L/min m(2)) and for TFC (males: 30-50 kohm(-1) and females: 21-37 kohm(-1)). The concordance between physician assessment and the BioZ was 51% for CI with Kappa of 0.14 and 58% for TFC with Kappa of 0.19. Attendings did slightly better than the surgical residents with CI (52% vs. 48%) but slightly worse with TFC (57% vs. 61%). The potentially serious conditions of low CI and high TFC were misdiagnosed 42% and 46% of the time, respectively, by all physicians. Analysis of the data revealed that physician use of clinically available objective hemodynamic data, such as heart rate, blood pressure, and pulse pressure index, would not have been helpful. Furthermore, assistance from the pulmonary artery catheter (PAC) is often not available in our hospital, which has experienced a 90% decrease in its utilization over the past six years. Considering the increasing acuity of our aging patient population, accurate assessment of cardiopulmonary status is needed. The use of ICG could be a valuable addition to the physician's armamentarium.
OBJECTIVE: To evaluate the following: (1) the intramethod variability of impedance cardiography (ICG) cardiac output (CO) measurements via the latest generation monitor and thermodilution CO measurements (CO-TDs); (2) the intermethod comparison of ICG CO and CO-TD; and (3) comparisons of the intergeneration ICG CO equation to CO-TD, using the latest ICG CO equation, the ZMARC (CO-ICG), and the predecessor equations for measuring the ICG CO of Kubicek (CO-K), Sramek (CO-S), and Sramek-Bernstein (CO-SB). DESIGN: Prospective study. SETTING: A cardiovascular-thoracic surgery ICU in a community university-affiliated hospital. PATIENTS: Post-coronary artery bypass graft patients (n = 53) in whom 210 pairs of CO measurements were made. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The CO-ICG was determined simultaneously while the nurse was performing the CO-TD. Variability within the monitoring method was better for CO-ICG compared to CO-TD (6.3% vs 24.7%, respectively). The correlation, bias, and precision of the CO-ICG was good compared to CO-TD (r(2) = 0.658; r = 0.811; bias, -0.17 L/min; precision, 1.09 L/min; CO-ICG = 1.00 x CO-TD - 0.17; p < 0.001). A steady improvement in agreement of the previous ICG methodologies compared to CO-TD was observed as follows: (1) CO-K: r(2) = 0.309; r = 0.556; bias, -1.71 L/min; precision, 1.81 L/min; CO-K = 0.78 x CO-TD - 0.45; p < 0.001; (2) CO-S: r(2) = 0.361; r = 0.601; bias, -1.46 L/min; precision, 1.63 L/min; CO-S = 0.80 x CO-TD - 0.36; p < 0.001; and (3) CO-SB: r(2) = 0.469; r = 0.685; bias, -0.77 L/min; precision, 1.69 L/min; CO-SB = 1.03 x CO-TD - 0.95; p < 0.001. The CO-ICG demonstrated the closest agreement to CO-TD. CONCLUSION: The latest ICG technology for determining CO (CO-ICG) is less variable and more reproducible in an intrapatient sense than is CO-TD, it is equivalent to the average accepted CO-TD in post-coronary artery bypass graft patients, and showed marked improvement in agreement with CO-TD compared to measurements made using previous generation ICG CO equations.
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Through-the-knee amputation (TKA) is an excellent lower extremity treatment for the ischemic extremity when revascularization is not feasible and a prosthesis is not practical. Over the past 8 years 185 major amputations have been performed at our hospital of which 63 were of the TKA type. In 61 of these an improved technique was used that resulted in nonischemic, strong, and aesthetic stumps with 100 per cent primary healing. Our technique consists of removing the distal 2 cm of the femoral head with the two condyles and allowing the patella to ankylose to the new distal femoral end. In comparison with the other major amputations the TKA with this technique had significant advantages over the above-knee amputation and often was found to be superior to the below-knee amputation especially when rehabilitative ambulation with a prosthesis was not possible.