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Biomedical subjects

Joshua D Auerbach

Publications and source records attributed to Joshua D Auerbach.

12 recordsLinked to original sources
PubMed2007

Posterior cervical arthrodesis for subacute odontoid fracture in a patient with osteopetrosis: case report.

STUDY DESIGN: A case of subacute odontoid fracture in a patient with osteopetrosis treated with posterior cervical arthrodesis using transarticular screws and interspinous wiring. OBJECTIVES: To report the first successful cervical arthrodesis in a patient with osteopetrosis and to highlight the potential perioperative pitfalls in this rare surgical population. SUMMARY OF BACKGROUND DATA: Osteopetrosis is a group of skeletal dysplasias characterized by osteoclast dysfunction, impaired bone resorption, and poor bone remodeling. Unique challenges associated with surgical fixation in osteopetrotic bone include a high incidence of nonunion, intraoperative fractures, intraoperative instrumentation failure, infection, and prosthesis loosening. We report the case of a patient with a subacute odontoid fracture treated successfully with posterior cervical arthrodesis using transarticular screws and interspinous wiring. METHODS: The surgical technique, intraoperative pitfalls, and 2-year follow-up data are reported. RESULTS: The patient underwent a successful posterior cervical arthrodesis using transarticular screws and interspinous wiring with autogenous iliac crest graft. At 2 years, a stable fixation was achieved with only mild postoperative limitation in neck range of motion. CONCLUSIONS: Cervical fractures and instability that require surgery in patients with osteopetrosis represent a unique challenge to the orthopedic spine surgeon. Despite the increased potential for perioperative instrumentation complications, nonunion, and infection, posterior cervical arthrodesis can be achieved and should be considered in the treatment armamentarium for this potentially catastrophic injury.

Adult↗
PubMed2007

Comparison of Cobb angle measurement of scoliosis radiographs with preselected end vertebrae: traditional versus digital acquisition.

STUDY DESIGN: Prospective study. OBJECTIVE: To compare variability in Cobb angle between digitally and traditionally acquired scoliosis radiographs. SUMMARY OF BACKGROUND DATA: Previous studies have shown that the 95% confidence interval for Cobb angle can vary from 2.6 degrees to 8.8 degrees. No study directly comparing Cobb angles measured from traditional and digitally acquired radiographs has been reported. METHODS: A spine model simulating 25 single right thoracic curves (range, 20 degrees-60 degrees) was imaged using traditional and digital techniques. Traditional films and miniaturized printed digital films were each measured twice manually. Digital films were also measured twice using computer imaging software. RESULTS: Overall mean angle and (95% confidence interval) were 41.7 degrees (39.1 degrees-44.3 degrees) for traditional, 40.6 degrees (37.4 degrees-43.8 degrees) for digital, and 39.7 degrees (36.3 degrees-43.1 degrees) for computer measurements. Overall correlation was 0.994 for traditional and digital, 0.987 for traditional and computer, and 0.993 for digital and computer. Fixed effect model analysis demonstrated that, although a statistically significant difference existed between the 3 methods of measuring the Cobb angle (P < 0.0001), the difference between methods was less than 2 degrees. CONCLUSIONS: Any of the 3 evaluated methods of measurement can be used to measure Cobb angles. Additionally, the methods can be used interchangeably.

Image Interpretation, Computer-Assisted↗
PubMed2006

Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report.

STUDY DESIGN: Case report. OBJECTIVE: To report on thoracic spinal cord compression caused by a mass in a 66-year-old female with new onset of myelopathic symptoms and a history of multiple hereditary exostoses. SUMMARY OF BACKGROUND DATA: To our knowledge, there have been no previous reports of spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine. METHODS.: Chart, pathologic, and radiographic documentation of the preoperative and postoperative clinical course of the patient was used. RESULTS: The patient had resolution of her neurologic symptoms following wide surgical excision, decompression, and stabilization from T2 to T10. The patient's mass was found to be breast adenocarcinoma metastatic to osteochondromas of the spine. CONCLUSIONS: When faced with a patient with a history of multiple hereditary exostoses with new onset of myelopathic symptoms and a mass compressing the spinal cord, the clinician's differential should be broad and always initially include a metastatic lesion, osteochondroma, or chondrosarcoma.

Adenocarcinoma↗
PubMed2006

Change in lordosis at the occipitocervical junction following posterior occipitocervical fusion in skeletally immature children.

STUDY DESIGN: Retrospective case series. OBJECTIVE: Evaluate the change in lordosis at the occipitocervical junction occurring during growth in skeletally immature children treated with posterior occipitocervical arthrodesis versus patients skeletally mature at arthrodesis. SUMMARY OF BACKGROUND DATA: Posterior occipitocervical arthrodesis is often indicated for children who have instability of the upper cervical spine develop. Theoretically, in skeletally immature children, this approach retards the growth of the posterior spinal elements but allows the anterior spinal column to continue to grow with the risk of excessive lordosis of the cervical spine developing. METHODS: There were 21 children, younger than 11 years (range 1.9-10.9) at surgery and expected to have normal spinal growth, followed radiographically for an average of 6.3 years (range 2.0-12.4). Postoperative lateral neutral radiographs were compared to those at most recent follow-up to measure the change in occipitocervical angle. These results were then compared to a series of control patients who were skeletally mature at surgery. RESULTS: Average overall change in lordosis at the occipitocervical junction was -4.6 degrees (range -12.8 degrees to +6.5 degrees). Average annualized change was -0.28 degrees per vertebral level per year (range -1.13 degrees to +0.67 degrees). This annualized change in angle was statistically significant compared to the average change of +0.01 degrees (range -0.09 degrees to +0.11 degrees) measured in the control series of patients skeletally mature at surgery (P = 0.01). CONCLUSIONS: Increasing lordosis occurs at the occipitocervical junction following fusion in skeletally immature children. If occipitocervical arthrodesis is indicated in a skeletally immature child, fusion in excessive extension and overtightening of posterior wires should be avoided.

Atlanto-Occipital Joint↗
PubMed2006

Assessment of human disc degeneration and proteoglycan content using T1rho-weighted magnetic resonance imaging.

STUDY DESIGN: T1rho relaxation was quantified and correlated with intervertebral disc degeneration and proteoglycan content in cadaveric human lumbar spine tissue. OBJECTIVE: To show the use of T1rho-weighted magnetic resonance imaging (MRI) for the assessment of degeneration and proteoglycan content in the human intervertebral disc. SUMMARY OF BACKGROUND DATA: Loss of proteoglycan in the nucleus pulposus occurs during early degeneration. Conventional MRI techniques cannot detect these early changes in the extracellular matrix content of the disc. T1rho MRI is sensitive to changes in proteoglycan content of articular cartilage and may, therefore, be sensitive to proteoglycan content in the intervertebral disc. METHODS: Intact human cadaveric lumbar spines were imaged on a clinical MR scanner. Average T1rho in the nucleus pulposus was calculated from quantitative T1rho maps. After MRI, the spines were dissected, and proteoglycan content of the nucleus pulposus was measured. Finally, the stage of degeneration was graded using conventional T2 images. RESULTS: T1rho decreased linearly with increasing degeneration (r = -0.76, P < 0.01) and age (r = -0.76, P < 0.01). Biochemical analysis revealed a strong linear correlation between T1rho and sulfated-glycosaminoglycan content. T1rho was moderately correlated with water content. CONCLUSIONS: Results from this study suggest that T1rho may provide a tool for the diagnosis of early degenerative changes in the disc. T1rho-weighted MRI is a noninvasive technique that may provide higher dynamic range than T2 and does not require a high static field or exogenous contrast agents.

Adolescent↗
PubMed2006

In vivo quantification of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging.

Diagnostic methods and biomarkers of early disc degeneration are needed as emerging treatment technologies develop (e.g., nucleus replacement, total disc arthroplasty, cell therapy, growth factor therapy) to serve as an alternative to lumbar spine fusion in treatment of low back pain. We have recently demonstrated in cadaveric human discs an MR imaging and analysis technique, spin-lock T(1rho)-weighted MRI, which may provide a quantitative, objective, and non-invasive assessment of disc degeneration. The goal of the present study was to assess the feasibility of using T(1rho) MRI in vivo to detect intervertebral disc degeneration. We evaluated ten asymptomatic 40-60-year-old subjects. Each subject was imaged on a 1.5 T whole-body clinical MR scanner. Mean T(1rho) values from a circular region of interest in the center of the nucleus pulposus were calculated from maps generated from a series of T(1rho)-weighted images. The degenerative grade of each lumbar disc was assessed from conventional T(2)-weighted images according to the Pfirmann classification system. The T(1rho) relaxation correlated significantly with disc degeneration (r=-0.51, P<0.01) and the values were consistent with our previous cadaveric study, in which we demonstrated correlation between T(1rho) and proteoglycan content. The technique allows for spatial measurements on a continuous rather than an integer-based scale, minimizes the potential for observer bias, has a greater dynamic range than T(2)-weighted imaging, and can be implemented on a 1.5 T clinical scanner without significant hardware modifications. Thus, there is a strong potential to use T(1rho) in vivo as a non-invasive biomarker of proteoglycan loss and early disc degeneration.

Adult↗
PubMed2006

Mastication causing segmental spinal motion in common cervical orthoses.

STUDY DESIGN: In vivo fluoroscopic quantification of segmental cervical spinal motion in asymptomatic volunteers during mastication. OBJECTIVE: To quantify the degree of segmental cervical spine motion in patients during mastication and while wearing several commonly used cervical orthoses. SUMMARY OF BACKGROUND DATA: Cervical orthoses are routinely used to stabilize the cervical spine after trauma or cervical fusion and are, in some cases, prescribed to be worn at all times, including during eating. METHODS: Seven volunteers with an average age of 31 years (range, 26-42 years) had 5 seconds of continuous lateral cervical fluoroscopic imaging while they chewed gum without any cervical orthosis (control) and while wearing a soft collar turned forward then backward, a Philadelphia collar, a Miami J collar, or a two-poster brace. Still images were created from the fluoroscopy video, which allowed for quantification of the amount of segmental motion. RESULTS: All cervical collars produced statistically greater motion at occiput-C1 and C1-C2 when compared with no collar. The motion was greatest at the occiput-C1 junction and decreased to the C4 level. No motion was detected in any subject in any brace below C4. The two-poster brace produced the most segmental motion at occiput-C1 (6.3 degrees +/- 2.0 degrees) compared with the soft collar turned backwards (1.9 degrees +/- 1.9 degrees). No subject had any segmental motion below C2 in the soft collar. No segmental spinal motion was observed without a cervical brace. CONCLUSIONS: To limit upper cervical spine segmental motion during mastication, for patients with unstable cervical spines, we propose a two-poster brace with removal of the mandibular component to allow for free mandibular action. For stable spines, we propose a soft collar turned backwards. Patients should be educated with this information.

Adult↗
PubMed2006

Sacral fractures.

Sacral fractures most commonly occur after pelvic ring injuries but occasionally in isolation. Although the true incidence of sacral fractures is unknown, an estimated 30% are identified late. Sequelae of inappropriately treated or untreated sacral fractures include persistent pain, decreased mobility, and neurologic compromise. Because these fractures often result from high-energy trauma, concomitant injuries should be suspected. A thorough physical examination, including a detailed neurologic assessment and radiographic evaluation, is necessary to determine treatment. Computed tomography of the pelvis/sacrum can provide significant information about fracture pattern. Surgical intervention, often as a combination of neural decompression and stabilization, is indicated in patients with neurologic deficits, significant soft-tissue compromise, and lumbosacral instability. Patient satisfaction with surgical intervention has not been definitively documented, although neurologic improvement with timely intervention has been noted.

Fracture Fixation↗
PubMed2005

Septic arthritis of the glenohumeral joint: a review of 23 cases.

Infection of the glenohumeral joint is an uncommon yet devastating condition. The objective of this study was to review the incidence, risk factors, presentation, and treatment for this disorder. Twenty-three culture-positive cases of septic arthritis of the glenohumeral joint were identified and treated at the authors' institution between 1986 and 2000. Eighty-seven percent of patients had at least one serious systemic illness, and on average had two. Fifty-two percent had a different primary site of infection identified. Staphylococcus aureus was identified as the infectious organism in 70% of cases, 17% of which were found to be methicillin-resistant S. aureus. Patients admitted to the orthopedic service were more likely to undergo surgical treatment. Patients treated surgically had shorter hospital stays than those treated with serial aspirations alone. Shoulder infections affect patients who are older and have multiple systemic diseases. Surgical treatment of shoulder infections, when compared to aspiration alone, is associated with a shorter hospital stay. Glenohumeral infection is a debilitating affliction even when control of the infection can be achieved.

Adult↗
PubMedDate not supplied

Tumors of the shoulder girdle: a review of 194 cases.

The upper extremity is the third most common site of primary bone and soft-tissue tumors. The purpose of this study was to determine the types and prevalence of bone and soft-tissue tumors that occur in the shoulder girdle and to identify physical findings that may be indicative of malignancy. This is a retrospective review of 194 consecutive neoplasms of the shoulder girdle seen by the senior author from 1996 through 2000. Benign tumors (n = 139) were more common than malignant tumors (n = 55). The presence of pain and the presence of mass were not risk factors for malignancy (P = .41 and P = .16, respectively). Malignant tumors occurred in an older population (P < .0007). Tenderness and tumor location in the scapula were also found to be risk factors for malignancy (P = .0002 and P = .0001, respectively). In summary, we have identified 3 variables that were found to be associated with malignancy in the shoulder girdle: older age, tenderness on palpation, and a lesion in the scapula.

Adolescent↗
PubMedDate not supplied

Variability of the metaphyseal-diaphyseal angle in tibia vara: a comparison of two methods.

Although Levine and Drennan described the metaphyseal-diaphyseal angle (MDA) in tibia vara using the lateral border of the tibial cortex, there is a lack of uniformity in the literature. The authors measured the MDA using both the lateral border and the center of the tibial shaft in 132 knees (66 patients) with bowleg deformity and examined whether there is a significant difference between these two measurements. At angles < or =11 degrees there was significant variance between the two methods. At angles >11 degrees, there was excellent correlation between the two methods and no statistical difference between the two methods. The authors conclude that either method of defining the longitudinal axis is acceptable to measure the MDA for the diagnosis and monitoring of tibia vara.

Bone Diseases, Developmental↗