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Biomedical subjects

Juan Murube

Publications and source records attributed to Juan Murube.

At least 19 recordsLinked to original sources
PubMed2006

Tear osmolarity.

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Animals↗
PubMed2005

Choosing the location of corneal incision based on preexisting astigmatism in phacoemulsification.

PURPOSE: To investigate the best location of clear-cornea incision in phacoemulsification, depending on preexisting corneal astigmatism. DESIGN: Randomized clinical trial and noncomparative interventional case series. METHODS: A total of 574 patients in five stages were assigned to the following incisions: superior or temporal (n = 89), superior (n = 141), superior or superior plus relaxing (n = 102), nasal or temporal (n = 156), and incisions based on applying conclusions of preceding and current studies (n = 86). Visual acuity, refraction, biomicroscopy, keratometry, and videokeratography (Fourier analysis) were performed before and after phacoemulsification and intraocular lens implantation (3.5-mm incision). main outcome measures: Corneal refractive and surface regularity index change between preoperative and 6-month postoperative examination. Visual acuity at 6 months. RESULTS: In patients without corneal astigmatism, corneal changes induced were greater in superior than temporal incision. After a superior incision (preoperative steep axis at 90 degrees), a shift of the axis 90 degrees away was less likely with at least 1.5 diopters of astigmatism. A perpendicular relaxing limbal incision decreased corneal changes. Nasal incision induced greater corneal change than temporal incision (preoperative steep axis at 180 degrees). A shift of this axis 90 degrees away was more likely with astigmatism < 0.75 diopters in temporal incision and < 1.25 diopters in nasal incision. CONCLUSIONS: Superior incision is recommended with at least 1.5 diopters of astigmatism and steep axis at 90 degrees. Temporal incision is recommended with astigmatism < 1.5 diopters and steep axis at 90 degrees, negligible astigmatism, or astigmatism < 0.75 diopters and steep axis at 180 degrees. Nasal incision is recommended with at least 0.75 diopters of astigmatism and steep axis at 180 degrees.

Aged↗
PubMed2005

Crocodile tears.

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Journal Article↗
PubMed2004

Ocular surface reflex in pseudocelli.

Light, when striking the ocular surface of terrestrial animals, is partially reflected by the lacrimal film, which can be seen as a bright spot on the cornea. This reflection, termed "the corneal reflex," should actually be called the "lacrimal film reflex," as it is reflected mainly by the lacrimal film. An isolated corneal reflex exists only in aquatic animals, which have no lacrimal film, and in abnormal conditions in terrestrial animals, e.g., when their corneas become dry. Some animals are able to mimic and reproduce the external appearance of the eyes of other species for defensive display purposes. In these eye-spots or pseudocelli, the ocular surface reflex is present as an important physiognomic feature in terrestrial animals. However, we have observed that it is absent in aquatic animals. We hypothesize that the corneal reflex of aquatic animals is very weak and inconspicuous due to the small difference of refractive index between water and cornea, and for this reason is not a physiognomic characteristic of their eyes. Thus, pseudocelli present on sub-aquatic animals do not display an ocular surface reflex.

Journal Article↗
PubMed2003

Subcutaneous abdominal artificial tears pump-reservoir for severe dry eye.

PURPOSE: To assay a totally implanted pump-reservoir unit placed under the subcutaneous tissue of the abdomen for providing artificial tears to the ocular surface in patients with severe dry eye. DESIGN: Prospective non-randomized comparative (self-controlled) trial. PARTICIPANTS: Six patients with severe dry eye, in whom intermittent moistening of the ocular surface with current collyria was clinically unsatisfactory. METHODS: The six patients were treated by implanting an artificial tear pump-reservoir unit under the subcutaneous tissues of the abdomen. The reservoir is operated by a gas pump, which pumps artificial tears to the eye from a 60-ml reservoir through a silicone tube leading subcutaneously from the reservoir, via the chest, neck and lateral part of the head, and entering the conjunctival sac over the lateral canthal ligament. The catheter is anchored to the aponeurosis of the temporal muscle at the lateral rim of the orbit with a butterfly sleeve. The terminal portion of the tube runs freely along the upper conjunctival fornix, and pours 1.5 ml/day of the artificial tears into the ocular lacrimal basin with a constant flow rate. The reservoir must be refilled by percutaneous injection of artificial tears every 45 days. MAIN OUTCOME MEASURES: Schirmer test, corneal fluorescein staining, lacrimal film breakup time, lacrimal osmolarity, corneal impression cytology, best-corrected visual acuity, dryness sensation and blepharospasm before and after lacrimal reservoir implantation. RESULTS: The lacrimal subcutaneous abdominal reservoir was well tolerated with little discomfort. A delivery of 1.5 ml/day was enough to maintain a comfortable wet eye. After an average follow-up of 15 months the signs and symptoms of dry eye were dramatically improved. Four of the patients had a severe blepharospasm, which disappeared some weeks after the implantation of the lacrimal abdominal reservoir. CONCLUSION: These are the first totally implanted lacrimal reservoirs in human beings. They have proved to be a good solution for severe dry eye. At present, this method is the only one that permits a maintained wet eye surface, and the performance of corneal, conjunctival, limbal and amniotic membrane transplants in total or almost total xerophthalmia. It may also be a good solution for some of the so-called essential blepharospasms, which are frequently triggered by an underlying dry eye.

Drug Delivery Systems↗