Biomedical subjects

Juan Premoli

Publications and source records attributed to Juan Premoli.

3 recordsLinked to original sources

PubMed2006

Risk factors for upper tract recurrence in patients undergoing long-term surveillance for stage ta bladder cancer.

PURPOSE: While the evidence is clear that patients with carcinoma in situ or high grade T1 TCC of the bladder are at higher risk for developing UUT tumors, the role of imaging the UUT in patients with Ta tumors remains controversial. We hypothesized that the number and frequency of recurrences in patients with Ta disease would allow us to identify a population who should undergo routine UUT surveillance. MATERIALS AND METHODS: We reviewed our database of 375 patients who underwent resection of a stage Ta TCC between 1975 and 1995. Median followup was 6 years. Patients were stratified according to the presence of an UUT occurrence, rate and timing of superficial recurrences, and grade of the initial bladder tumor. RESULTS: Among the 375 patients 50% had no bladder recurrence, 25% had 1 tumor, 15% had 2 tumors, and 10% had 3 or more tumors. Average time between tumors was 17 months. UUT tumor developed in 13 patients (3.4%) at an average of 22 months after their initial bladder tumor. A high risk group consisting of patients who had 2 or more bladder recurrences recurring within 12 months of each other were at 4.5-fold the risk of UUT tumor. CONCLUSIONS: Stage Ta bladder cancer patients with 2 or more recurrences of bladder tumors with a median of less than 12 months between recurrences are at higher risk for developing an UUT tumor and should be considered for more frequent UUT surveillance.

Carcinoma, Transitional Cell↗

PubMed2005

Randomized evaluation of Ureteral Stents using validated Symptom Questionnaire.

BACKGROUND AND PURPOSE: Ureteral stents are associated with significant pain and urinary symptoms. Manufacturers have altered stent designs and materials in an attempt to minimize this morbidity. This study evaluated the impact of these modifications. PATIENTS AND METHODS: Stent manufacturers were asked to provide the 6F ureteral stent they believed would be associated with the least patient discomfort. Patients undergoing uncomplicated ureteroscopy were randomized to the Bard Inlay, Cook Endo-Sof, Microvasive Contour, Applied Medical Vertex, or Surgitek Classic Double-Pigtail stent. The Ureteric Stent Symptom Questionnaire (USSQ) was administered on days 1, 3, and 5, and the patients maintained a narcotic diary. The data were analyzed using ANOVA and nonparametric methods. RESULTS: A total of 44 patients (73%) completed all USSQ questionnaires. Urinary symptom scores were significantly lower for the Inlay stent on day 3 than for the Vertex (P = 0.01), Contour (P = 0.05), Endo-Sof (P = 0.03), and Classic (P = 0.02) stents. No significant differences were noted in pain and general symptom scores or narcotic use. CONCLUSIONS: The Bard Inlay stent is associated with less-severe urinary symptoms than other ureteral stents. The USSQ is a sensitive tool to measure differences between stents.

Adult↗

PubMed2004

Forearm compression by laparoscopic hand-assist devices.

BACKGROUND AND PURPOSE: Laparoscopic hand-assist devices have facilitated the broad application and acceptance of laparoscopy in urology and other surgical fields. This study evaluated forearm compression by these devices. MATERIALS AND METHODS: Five commercially available hand-assist devices were tested (Gelport, Intromit, PneumoSleeve, Handport, LapDisc). In three surgeons using a porcine model, compressive forces were measured along the paths of the median and ulnar nerves at the point of maximum proximal forearm circumference using FlexiForce A101 sensors. Glove size for all three surgeons was 7 1/2; however, the maximum forearm circumference ranged from 26 to 33 cm. The hand-assist devices were placed in pigs after skin and fascial incision (9 cm), and the insufflation pressure was set at 18 mm Hg. Surgeons subjectively rated the ease of device insertion and hand insertion, degree of forearm compression, and the development of paresthesias. RESULTS: The LapDisc was rated superior with regard to insertion. The Gelport was rated superior for hand insertion and removal; however, moderate to severe forearm compression and paresthesias were reported. The maximum forearm compression forces were highest with the LapDisc (97 mm Hg) and the Gelport (78 mm Hg) and lowest with the Handport (33 mm Hg). CONCLUSION: The choice of hand-assist device is dependent on its ease of use, efficacy at maintaining insufflation, and effect on the surgeon's performance and fatigue. The impact of forearm compression should be considered in the selection of the hand-assist device and in the development of new devices.

Animals↗