Biomedical subjects

Judith Anderson

Publications and source records attributed to Judith Anderson.

6 recordsLinked to original sources

PubMed2006

Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.

PURPOSE: The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (mTOR) pathway and the heat shock protein family are up-regulated in multiple myeloma and are both regulators of the cyclin D/retinoblastoma pathway, a critical pathway in multiple myeloma. Inhibitors of mTOR and HSP90 protein have showed in vitro and in vivo single-agent activity in multiple myeloma. Our objective was to determine the effects of the mTOR inhibitor rapamycin and the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on multiple myeloma cells. EXPERIMENTAL DESIGN: Multiple myeloma cell lines were incubated with rapamycin (0.1-100 nmol/L) and 17-AAG (100-600 nmol/L) alone and in combination. RESULTS: In this study, we showed that the combination of rapamycin and 17-AAG synergistically inhibited proliferation, induced apoptosis and cell cycle arrest, induced cleavage of poly(ADP-ribose) polymerase and caspase-8/caspase-9, and dysregulated signaling in the phosphatidylinositol 3-kinase/AKT/mTOR and cyclin D1/retinoblastoma pathways. In addition, we showed that both 17-AAG and rapamycin inhibited angiogenesis and osteoclast formation, indicating that these agents target not only multiple myeloma cells but also the bone marrow microenvironment. CONCLUSIONS: These studies provide the basis for potential clinical evaluation of this combination for multiple myeloma patients.

Antineoplastic Combined Chemotherapy Protocols↗

PubMed2004

The eHealth Behavior Management Model: a stage-based approach to behavior change and management.

Although the Internet has become an important avenue for disseminating health information, theory-driven strategies for aiding individuals in changing or managing health behaviors are lacking. The eHealth Behavior Management Model combines the Transtheoretical Model, the behavioral intent aspect of the Theory of Planned Behavior, and persuasive communication to assist individuals in negotiating the Web toward stage-specific information. It is here - at the point of stage-specific information - that behavioral intent in moving toward more active stages of change occurs. The eHealth Behavior Management Model is applied in three demonstration projects that focus on behavior management issues: parent-child nutrition education among participants in the U.S. Department of Agriculture Special Supplemental Nutrition Program for Women, Infants and Children; asthma management among university staff and students; and human immunodeficiency virus prevention among South African women. Preliminary results have found the eHealth Behavior Management Model to be promising as a model for Internet-based behavior change programming. Further application and evaluation among other behavior and disease management issues are needed.

Adult↗

PubMed2004

Developing support for remote nursing education through workplace culture that values learning.

OBJECTIVE: The present study presents the cultural challenges of introducing workplace learning associated with a nursing educational pathway into small rural hospitals. DESIGN AND INTERVENTION: Focus groups were conducted before and after an action research intervention to determine whether changes in understanding and values on learning had occurred. SETTING: Eight multipurpose services or small rural hospitals across rural New South Wales were involved in the intervention. SUBJECT: Nursing staff from eight rural health facilities participated voluntarily in the present study. OUTCOMES: Two outcomes were achieved: The development of mentoring, locally tailored to the needs and expectations of nursing participants; Values and understanding of learning were enhanced, with advanced levels of learning being identified and demonstrated by staff in the practice setting. CONCLUSION: Small rural hospitals can provide opportunities for advanced clinical learning. Forms of major mentoring are, however, critical to this process.

Attitude of Health Personnel↗

PubMed2003

Analysis of the concept of aloneness. As applied to older women being treated for depression.

The concept of aloneness is examined in very few published materials. This article analyzes the concept of aloneness through the experiences of eight older women being treated for depression. When the women were depressed, they viewed aloneness as being vulnerable, fearful, helpless, and as having a loss of control of self and identity confusion. As the women progressed in their recovery from depression, they viewed aloneness as being self-reliant, hopeful, and resourceful and as having self-determination and self-reflection. Establishing and clarifying the meaning of aloneness for older women during their depression and during their recovery from depression is basic to using the concept of aloneness in nursing theory development and in gerontological nursing practice, education, and research.

Adaptation, Psychological↗

PubMedDate not supplied

Nursing interventions for the management of patients with mania.

This article explores mania, a serious and often chronic illness that is mostly related to bipolar disorder but can present by itself or as a symptom of other illnesses. The signs and symptoms of the condition are examined and the nursing interventions reviewed.

Bipolar Disorder↗

PubMedDate not supplied

Culture of rural nursing practice: a critical theoretical analysis of determinants of power in nursing.

OBJECTIVE: This paper investigates the culture of workplace learning within a study of eight small hospitals in rural New South Wales (NSW), Australia. DESIGN: The study used a focus group method of data collection, undertaken before then after a series of interventions designed to nurture a culture that supports learning within the rural health care setting. PARTICIPANTS: Student AINs, AINs, ENs and RNs from any of the eight hospitals. CONCLUSION: Framed within a critical social perspective it applies a theory of culture to understand the determinants of social divisiveness that was occurring between different levels of the nursing workforce. These results are further analysed within a theoretical discussion of culture and power in nursing.

Education, Nursing, Continuing↗