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Biomedical subjects

Jun Lu

Publications and source records attributed to Jun Lu.

186 records · Page 11Linked to original sources
PubMed2002

[The association between uric acid and coronary heart disease].

OBJECTIVE: To determine the association between uric acid and coronary artery disease (CAD) and whether the relationship is gender dependent. METHOD: A cross-sectional study of 355 men and women with or without CAD was performed. Coronary artery angiography was done for all the subjects. Patients treated with diuretics, isopurinol, aspirin, lipid-lowering agents and heparin and patients with renal, hepatic, or thyroid diseases were excluded. Gender, age, body mass index, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, cigarette smoking consumption, CAD family history, essential hypertension history and CAD severity were analyzed. Cigarette smoking consumption was graded as follows: 0: no smoking, 1: </= 5 pack-year, 2: 5 to 10 pack-year, 3: greater than 10 pack-year. CAD severity was scored angiographically as follows: 0 (absent): no evidence of CAD; 1 (mild): 1-vessel disease with < 50% stenosis; 2 (moderate): 1-vessel disease with >/= 50% stenosis, or 2-vessel disease, both vessels with < 50% stenosis or 1 with < 50% and the other with > 50% stenosis, or 3-vessel disease, all with < 50% stenosis; 3 (severe): 2-vessel disease, both with > 50% stenosis, or 3-vessel disease with >/= stenosis in one vessel > 50%. RESULTS: The upper uric acid qunrtiles in the women group were associated with higher CAD severity than the lower uric acid qunrtiles. The mean CAD severity score according to the uric acid qunrtiles were 2.10 (uric acid 163 approximately 217.5 micro mol/L) 2.27, (uric acid 218.0 approximately 276.0 micro mol/L) 2.36 (uric acid 277.0 approximately 335.0 micro mol/L) and 2.62 (uric acid 336.0 approximately 694.0 micro mol/L). No such relation was found in men. With multiple logistic regression, gender (B = 0.924, P = 0.012, OR = 2.520), fasting plasma glucose (B = 0.391, P = 0.006, OR = 1.478), fibrinogen (B = 0.007, P = 0.000, OR = 1.007) and cigarette smoking consumption grading (B = 0.306, P = 0.018, OR = 1.358) were independently associated with CAD, there was a trend association between age and CAD (B = 0.032, P = 0.056, OR = 1.032), Uric acid (B = 0.002, P = 0.349, OR = 0.998) and other variables did not have significant independent association with CAD. With stepwise multiple regression analysis, fibrinogen, fasting plasma glucose, total cholesterol, gender, age showed significant independent association with CAD severity, but uric acid (B = 0.004, beta = 0.025, t = 0.373, P = 0.709) and other variables did not. In the female group, CAD or CAD severity was independently associated with triglyceride and fibrinogen, but not with uric acid. CONCLUSIONS: The upper uric acid qunrtiles in the women group have higher CAD severity than the lower uric acid qunrtiles. However, with multiple regression, either in women or in men, uric acid was not independently associated with CAD or CAD severity.

Adult↗
PubMed2002

Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes.

The survival and expansion of effector cytotoxic T lymphocytes (CTLs) during an immunological response are critical for the successful elimination of life-threatening attacks by microorganisms, parasites, or malignant cells. Among the numerous factors that regulate the immune response, interleukin (IL)-2, and its close relative, IL-15 are known to function as growth and survival factors for antigen-experienced T cells. However, major differences appear to exist between these lymphokines in their capacity to act on various T-cell types such as CD4+ versus CD8+ or effector versus memory T lymphocytes. Although several studies have been done in the mouse system, less information is available regarding the function of these lymphokines in the human system. Here, we report that IL-15 or high concentrations of IL-2 induced antigen-independent expansion of effector CD8+ CTLs. Neither IL-2 nor IL-15 induced the proliferation of CD4+ T cells. In the absence of antigen, at least one of these lymphokines was required for the long-term survival of the cells in tissue culture. Most significantly, the effector cytolytic activity of CTLs expanded and maintained in IL-15 for up to 60 days remained stable, indicating that these cells do not differentiate into a memory functional phenotype. The expression of IL-15Ralpha, which was detected on CD8+ CTLs but not on CD4+ helper T cells, suggests that this receptor subunit somehow participates in the transduction of the mitogenic signals of IL-15. The present findings have practical implications for the propagation of antigen-specific T-cell lines in vitro and could be useful for expansion of therapeutic T cells for adoptive transfer.

CD4-Positive T-Lymphocytes↗
PubMed2002

[Application of cryosurgery in the treatment of liver carcinoma].

Friotherapy, using liquid N2 as cryogen, may be applied for all stages of liver cancer, which mechanism is tissue destruction due to low temperature, directly and improvement of immunity. At present, using multiprobe cryosurgical device result in many treatment options, such as procedure under open abdomen and staring blankly forward or percutaneously under Trus guidance. The advantages of cold therapy include its convenience, few complications, approval results, ect. With the invention of new probes and cryogen, cryosurgery as a treatment for liver cancer will have a good prospect.

Cryosurgery↗
PubMed2001

Ultrasound-Induced Formation of CdS Nanostructures in Oil-in-Water Microemulsions.

In this study the formation of approximately spherical assemblies of nanocrystalline primary particles of CdS in a CS(2)-water-ethylenediamine (CWE) microemulsion induced by ultrasonic irradiation is described. CS(2) was employed as the sulfur source for CdS and also as the oil phase in the microemulsion. The particles were studied with X-ray powder diffraction, transmission electron microscopy, UV/Vis absorption spectroscopy, and photoluminescence spectroscopy. A blue shift compared to bulk CdS was observed in absorption and photoluminescence spectra. Copyright 2001 Academic Press.

Journal Article↗
PubMedDate not supplied

Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1.

Interleukin-5 (IL-5) plays a central role in the growth and differentiation of eosinophils and contributes to several disease states including asthma. There has been considerable interest in the identification of the transcriptional mechanisms controlling the synthesis of this cytokine. The regulation of IL-5 message is primarily at the level of transcription and is likely to be controlled, to a large extent, by regulatory elements in the promoter region that can influence the transcriptional activity of the gene. In this study, we performed a series of transient transfection experiments with IL-5 promoter-reporter gene construct and expression plasmid for E1A, an inhibitor of CBP/p300, or for the CBP/p300-binding defective E1A Delta 2-36. The results showed that E1A repressed IL-5 promoter activity, while E1A Delta 2-36 had no effect on it. This suggested that CBP/p300 was involved in regulation of IL-5 gene expression. Transcriptional coactivator CBP/p300 and transcription factors C/EBP, NF-AT, and c-Fos synergistically activated IL-5 promoter. Furthermore, we found that ectopic expression of p300 increased endogenous IL-5 mRNA expression. Thus, the histone acetyltransferase (HAT) activity of CBP/p300 was required to activate IL-5 expression. This report provided evidence, for the first time, that CBP/p300 was involved in IL-5 gene expression and the HAT activity was important in regulation of IL-5 expression.

Acetyltransferases↗