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Jun-ichi Adachi

Publications and source records attributed to Jun-ichi Adachi.

4 recordsLinked to original sources
PubMed2006

Papillary glioneuronal tumor with minigemistocytic components and increased proliferative activity.

Papillary glioneuronal tumor (PGNT) is a rare and new type of glioneuronal neoplasm of the central nervous system. It is characterized by pseudopapillary structures composed of hyalinized vessels rimmed by cuboidal glial cells and the proliferation of neuronal cells. We report a peculiar PGNT arising in the parietal lobe of a 67-year-old man, which was characterized by proliferation of minigemistocytic cells as well as typical components. The minigemistocytic cells had eccentric nuclei and plump eosinophilic cytoplasm that was filled with glial filaments. The Ki-67 labeling index was as high as 10% in the minigemistocytic areas. Recently, the presence of oligodendroglial-like component was suggested in PGNT. Considering that oligodendroglioma sometimes accompanies minigemistocytic components, the minigemistocytic cells in PGNT were suggested to be a part of oligodendroglial differentiation. Although PGNT is defined as an indolent glioneuronal tumor, the presence of minigemistocytic components with the high Ki-67 labeling index may indicate more aggressive nature.

Aged↗
PubMed2005

Mixed neuronal-glial tumor of the fourth ventricle and successful treatment of postoperative mutism with bromocriptine: case report.

BACKGROUND: Tumors composed of both neurocytic and astrocytic cells are uncommon and poorly understood. We describe the clinicopathologic features of a very rare rosette-forming glioneuronal tumor of the fourth ventricle and propose bromocriptine as a useful therapeutic agent for cerebellar mutism after posterior fossa surgery. CASE DESCRIPTION: A fourth ventricle tumor was incidentally discovered in an 18-year-old woman. Magnetic resonance imaging revealed ventriculomegaly and a solid tumor with low-intensity signals on T1-weighted images and high-intensity signals on T2-weighted images. There was slight gadolinium enhancement. The tumor was subtotally resected. Although its lower half was well circumscribed, its upper half manifested invasive growth. Histologically, 2 components were identified, synaptophysin-positive neurocytic cells forming perivascular pseudorosettes and glial fibrillary acidic protein-positive astrocytic cells with Rosenthal fibers. Overall, cellular atypia was minimal and the MIB-1 labeling index was low. On the basis of these histologic findings, the tumor bore striking similarity to the recently described rosette-forming glioneuronal tumors of the fourth ventricle. Postoperatively, the patient manifested cerebellar mutism. The administration of bromocriptine improved her neurological status dramatically. CONCLUSION: The natural history of rosette-forming glioneuronal tumors of the fourth ventricle is not yet fully understood. Therefore, careful and long-term follow-up monitoring of the tumor hosts is necessary. Bromocriptine therapy may promote recovery from mutism after posterior fossa surgery.

Adolescent↗
PubMed2002

[Effect of tonometry on a glaucoma population study].

PURPOSE: The purpose of this study was to evaluate the influence of tonometry in detecting the occurrence of glaucoma. METHODS: The subjects, 845 out of 3,488 residents aged 40 years or older, were examined according to standard protocols, including tonometry, slit lamp examination, fundus photography, and automatic perimetry as a recall examination. The intraocular pressure in each subject was measured by both Goldmann applanation tonometer(GAT) and noncontact tonometer CT-70 (NCT). RESULTS: The mean +/- standard deviation intraocular pressure measured by GAT was 15.52 +/- 2.57 mmHg, and 15.03 +/- 2.90 mmHg by NCT. There was a statistically significant correlation(p < 0.0001). The difference between pairs of measurements by GAT and NCT was 0.50 +/- 1.93 mmHg. There was no influence of tonometry in detecting the incidence of glaucoma, which was 4.14%; primary open-angle glaucoma 0.59%, normal tension glaucoma 2.6%, primary angle-closure glaucoma 0.47%, and other types of glaucoma 0.48%. The detection of ocular hypertension was different, and was 2.13% with GAT and 2.72% with NCT. CONCLUSION: In our study, the influence of tonometry in detecting the incidence of glaucoma was very small. A noncontact tonometer is considered to be useful for glaucoma population study.

Adult↗