Biomedical subjects

Justin C Lee

Publications and source records attributed to Justin C Lee.

4 recordsLinked to original sources

PubMed2006

Soft tissue masses with "cyst-like" appearance on MR imaging: Distinction of benign and malignant lesions.

The purpose of this study was to assess the reliability of MR imaging features in distinguishing between benign and malignant soft tissue masses that have a "cyst-like" appearance (hypointense to muscle on T1-weighted and hyperintense on T2-weighted or fluid-sensitive MR sequences). MR imaging features of 40 patients with histologically proven soft tissue masses (27 benign and 13 malignant lesions) that were hypointense to muscle on T1-weighted and hyperintense on T2-weighted or fluid-sensitive MR sequences were analysed to see if a distinction could be made between benign and malignant lesions. There were 23 females and 17 males (mean age, 56 years; age range, 23-82 years). MR imaging features analysed for statistical significance included lesion size, lesion homogeneity, presence of lobulation, depth in relation to fascia and border definition. Clinical assessment included the age and sex of the patient and location of the lesion. Statistically significant MR imaging features favouring a diagnosis of a malignant lesion included larger average dimension of the mass (P < or = 0.004), larger greatest dimension of the mass (P < or = 0.028) and heterogeneity of the lesion on T1-weighted sequences (P = 0.017). The most statistically significant predictor of malignancy was the larger average dimension of the mass.

Adult↗

PubMed2006

Aggressive fibromatosis: MRI features with pathologic correlation.

OBJECTIVE: We present the MRI features with pathologic correlation of aggressive fibromatosis, incorporating 203 cases over a 5-year period from the Royal Marsden Hospital Sarcoma Unit database. MATERIALS AND METHODS: Sixty patients had imaging available for retrospective review of which 29 had preoperative MRI and final histopathologic diagnosis of aggressive fibromatosis. RESULTS: The average age at diagnosis was 41.3 years with a female-to-male sex ratio of 1.2:1. Twenty lesions were extraabdominal; six, intraabdominal; and three, in the abdominal wall (classic desmoid). The average tumor size was 6.4 cm (range, 2.2-13.7 cm). Intraabdominal aggressive fibromatosis produced the largest tumors, averaging 9.5 cm. Most lesions were ovoid (52%) or infiltrative (34.5%) in outline with an irregular or lobulated contour (76%). The lesions crossed major fascial boundaries in 31% of cases overall and in 66% of patients referred for recurrent disease. On MRI, homogeneous isointensity or mild hyperintensity on T1-weighted images and heterogenous high signal on T2-weighted or STIR images were seen. All lesions enhanced after IV gadolinium, usually avidly. In contrast to previous reports, 38% of cases failed to show low signal on all pulse sequences and no abnormalities were seen in local bone structures. Histology showed sheets of bland spindle cells in dense collagen and did not vary with the MRI signal characteristics of the lesion. Patients referred for recurrent disease were most likely to have a recurrence after surgery. MRI and pathology findings did not predict recurrence. CONCLUSION: Accurate diagnosis and staging of aggressive fibromatosis by MRI have important treatment and prognostic implications.

Adolescent↗

PubMed2006

MRI of stress reaction of the distal humerus in elite tennis players.

OBJECTIVE: The purpose of this study was to describe the MRI appearance of stress reaction in the distal humerus in 12 elite tennis players. In addition, we aimed to determine whether any MRI findings were associated with changes in recovery times. CONCLUSION: Stress injury to the distal humerus is a cause of chronic arm pain among elite tennis players and may be exacerbated during full competition. The degree of marrow edema on STIR MRI may be predictive of time to return to competition.

Adolescent↗

PubMedDate not supplied

Normal sonographic anatomy of the wrist and hand.

The advent of ultra-high-frequency sonographic transducers has significantly enhanced our ability to image superficial structures. As a result, sonography now can be used to assess injuries of the tendons in the wrist and hand. A clear understanding of normal sonographic anatomy is required to prevent misdiagnosis and ensure optimal patient care. The anatomy of the wrist and hand is best described by considering the extensor and flexor surfaces separately. The carpal extensor retinaculum divides the dorsal extensor tendons into six separate synovial compartments, which are demarcated by the points of its attachment to the radius and ulna. The course of these tendons from the wrist to the sites of their insertion can be traced by using sonography. The intrinsic wrist ligaments, triangular fibrocartilage, and dorsal finger extensor hood also can be assessed sonographically. The anatomy of the flexor surface of the wrist is defined principally by the flexor retinaculum. The median nerve, which is located deep to the retinaculum in the carpal tunnel, and the ulnar nerve, which is superficial to the retinaculum in the Guyon canal, can be easily detected. The long flexor tendons in the wrist and hand are also clearly depicted at sonography. The flexor annular pulley system is formed by five foci of thickening along the long flexor finger tendon synovial sheath, and the second and fourth annular pulleys can be identified sonographically in most patients. Sonography provides a rapid, cheap, noninvasive, and dynamic method for examination of the soft-tissue structures of the wrist and hand. Familiarity with the appearance of normal anatomic structures is a prerequisite for reliable interpretation of the resultant sonograms.

Hand↗