Biomedical subjects

K A Broholm

Publications and source records attributed to K A Broholm.

2 recordsLinked to original sources

PubMed1978

Serological diagnosis of pneumococcal disease with enzyme-linked immunosorbent assay (ELISA).

Antibody response to pneumococcal type-specific polysaccharide was measured with enzyme-linked immunosorbent assay (ELISA). The test was shown to be up to 500 times more sensitive than indirect hemagglutination using chromic chloride-treated red blood cells. In 16/17 patients with pneumococcal pneumonia a significant antibody increase was seen as measured with ELISA. Only 6/23 patients with pneumonia caused by Mycoplasma pneumoniae gave a pneumococcal antibody rise and in those cases the increase was very slight. The authors consider ELISA a valuable contribution to the serological diagnosis of pneumococcal disease.

Adult↗

PubMed1977

Ornithosis as a nosocomial infection.

An outbreak of ornithosis in the department of infectious diseases of a general hospital is described. The outbreak comprised 12 cases aged 18-80 years. The index case had a history of contact with birds. He developed a serious illness and died. 11 persons contracted the disease after contact with the index case; 8 of them were personnel of the clinic of infectious diseases and 1 case was a patient hospitalized in the same room as the index case. All of the patients showed a typical pneumonia and one of them had symptoms of encephalitis. Treatment with doxycycline was successful. 200 healthy contacts were treated prophylactically with doxycycline. None of these displayed any symptoms of disease.

Adolescent↗