Biomedical subjects

K A Cope

Publications and source records attributed to K A Cope.

5 recordsLinked to original sources

PubMed1998

Organizational features affecting the use of coercion in the administration of psychiatric care.

Historically, the use of coercion in psychiatric hospital admissions, and research on such use, have reflected social circumstances that impact on psychiatric care. Currently, the social emphasis on cost-saving in the U.S. and corresponding shifts in the organization, financing, and management of psychiatric and mental health care, have begun to affect research on the use of coercion in psychiatric admissions. Such research has begun to incorporate hospital organizational dynamics which affect the use of coercion in these admissions. The authors propose that this emphasis should be expanded into a comprehensive research agenda that examines the most pertinent organizational features affecting the use of coercion in psychiatric hospital admissions.

Attitude to Health↗

PubMed1997

A new immunocompetent murine model for oral cancer.

OBJECTIVE: To develop and characterize a new immunocompetent murine model that attempts to parallel the clinical and biological nature of head and neck cancer. DESIGN: The growth rate and histologic characteristics of the SCC VII/SF cell line were initially determined in tissue culture experiments. Animal experiments were subsequently performed on C3H/HeJ mice. Using direct injection, 5 x 10(5) SCC VII/SF cells were delivered to the floor of the mouth of each animal. Animals were killed after 1, 2, and 3 weeks, and tumor growth, invasion, and regional and distant metastases were evaluated. RESULTS: Squamous cell carcinomas that could be palpated and measured externally were identified in the floor of the mouth of C3H/HeJ mice after 5 to 7 days. Local invasion into the mylohyoid musculature and mandible was present. Cervical lymph node and pulmonary metastases were identified between 2 and 3 weeks. CONCLUSIONS: This study introduces a new oral cancer animal model that shows initial locoregional tumor invasion, direct extension into the neck, early cervical metastases, and pulmonary metastases. These clinical and histopathologic attributes reflect the biological behavior and tumor progression seen in human oral cancer and therefore provide a model for clinically applicable research for primary and metastatic head and neck cancer.

Animals↗

PubMed1996

Combination gene therapy for oral cancer in a murine model.

Combination therapy involving adenovirus-mediated transfer of the genes for herpes thymidine kinase (tk) and murine interleukin 2 (mIL-2) was used to treat head and neck cancer in C3H/HeJ mice. Tumors were generated by transcutaneous injection of 5 X 10(5) murine squamous carcinoma cells into the floor of the mouth of these syngeneic mice. After 1 week, recombinant adenoviral vectors containing both therapeutic and control genes in various combinations were injected directly into the established tumors, and subsequently all mice were administered ganciclovir twice daily (25 mg/kg) for 6 days. Animals receiving either tk alone or tk + mIL-2 demonstrated significant tumor regression compared to mIL-2 alone or control vector-treated mice (P < 0.008). Mice receiving both tk + mIL-2, however, also demonstrated a significantly greater regression of tumors compared to those treated with tk alone (P<0.008), indicating a synergistic effect of the combination gene therapy. This synergism was confirmed in survival studies because tk + mIL-2 treated mice showed increased survivals (P=0.0002). Clinical and microscopic exam of regional surrounding tissues and distant organs showed no evidence of cytotoxicity for representative animals in each experimental group. These results suggest that combination tk and mIL-2 gene therapy may provide a powerful new modality for the treatment of head and neck cancer.

Adenoviridae↗

PubMedDate not supplied

Interdisciplinary documentation of patient education: how collaboration can effect change.

Changing healthcare trends are affecting all healthcare providers today, including those at Hillside Rehabilitation Hospital. Computerizing the interdisciplinary documentation of patient information was one change Hillside's leaders implemented to remain competitive and cost-effective. The benefits of moving from a handwritten documentation system to a computerized system were many. However, unforeseen difficulties with retrieving data became evident because the system was not developed to accommodate information about patient education. Through interdisciplinary collaboration, staff identified areas for improvement and made changes to the documentation process. They developed a "traveling card" for documenting patient education and then met a new set of challenges. The new documentation system met departmental and Joint Commission on Accreditation of Healthcare Organizations requirements for comprehensive patient education and documentation.

Cooperative Behavior↗

PubMedDate not supplied

Nutritional status: a basic 'vital sign'.

The purpose of this article is to alert and inform the home healthcare nurse about the national focus on the unacceptably high levels of malnutrition in the elderly; its significance in patient outcome; the effort of the Nutrition Screening Initiative to help all healthcare professionals incorporate routine nutrition screening and intervention activities into healthcare practice; and the simple screening tools available to assist in evaluations.

Aged↗