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Biomedical subjects

K A Perkins

Publications and source records attributed to K A Perkins.

At least 109 records · Page 6Linked to original sources
PubMed1988

Maintaining smoking abstinence after myocardial infarction.

Maintaining smoking abstinence after a myocardial infarction (MI) greatly reduces risks of recurrent disease morbidity and of mortality. Although post-MI patients appear to have better long-term rates of smoking abstinence compared with healthy groups, studies employing biochemical verification of smoking status generally indicate that only about one third of previously smoking post-MI patients remain abstinent at follow-up. Factors which may accompany the occurrence of a MI and which may be associated with maintenance of smoking abstinence include environmental changes aiding cessation (e.g., decreased exposure to smoking cues), increased social support from family, and stronger belief in the harmful effects of continued smoking. The usefulness of these factors in developing new treatments for maintaining abstinence in post-MI patients is discussed, and commonalities between efforts to maintain smoking abstinence in post-MI patients and avoidance of substance abuse in other groups at risk for serious health consequences are briefly noted.

Cause of Death↗
PubMed1987

Weight gain associated with decreases in smoking rate and nicotine intake.

The mechanisms involved in the weight gain associated with smoking cessation are not well known. This study employed a single-subject design to investigate changes in weight following systematic reductions in smoking rate and cigarette nicotine content. Although there were no changes in the subject's caloric intake or physical activity, a weight gain of 3.6 kg was observed after 4 months of reduced rate and nicotine intake. These results suggest that weight change during smoking reduction and cessation may be primarily due to changes in factors other than caloric intake or activity.

Body Weight↗
PubMed1986

The cardiovascular effects of nicotine during stress.

The acute cardiovascular effects of smoking during stress may be greater than those of smoking or stress alone, a finding which could have implications for determining which smokers may be at particular risk for coronary heart disease (CHD). Methodological problems inherent in using tobacco smoking to deliver nicotine (believed responsible for smoking's cardiovascular effects) prevent clear examination of the cardiovascular effects of inhaled nicotine. This study compared the cardiovascular increases due to a video game stress task plus 1.0 mg nicotine with those of stress or nicotine alone using an aerosol method of presenting nicotine in measured doses. Twelve young male smokers each participated in four conditions on 4 separate days: stress + nicotine, stress + placebo (stress alone), rest + nicotine (nicotine alone), and rest + placebo. The effects of stress and nicotine were additive for heart rate but less than additive for systolic and diastolic blood pressure. These results indicate that the combined effects of stress and nicotine may be relevant to understanding the prevalence of CHD among smokers. They also suggest that the effects of each on cardiovascular activity may be different, as the effects are independent for heart rate but overlap for blood pressure.

Adolescent↗
PubMed1986

Cardiovascular reactivity to psychological stress in aerobically trained versus untrained mild hypertensives and normotensives.

Cardiovascular reactivity to video game and mental arithmetic stressors was compared among three groups of men: aerobically trained mild hypertensives, untrained mild hypertensives, and a comparison group of untrained normotensives. Relative to the untrained hypertensives, the trained hypertensives reacted to the video game with marginally smaller systolic blood pressure and diastolic blood pressure, but there were no significant differences between these groups in reactivity during the mental arithmetic task. Comparisons between each hypertensive group and the normotensive group showed that blood pressure (BP) reactivity of normotensives during the video game was generally similar to that of trained hypertensives but smaller than that of untrained hypertensives. These results indicate that aerobic training, which has been found to reduce resting BP in mild hypertensives, may also exert a favorable impact in reducing cardiovascular reactivity of hypertensives during some stressful situations.

Adult↗
PubMed1986

Ten-year follow-up of drug abusers with acute or chronic psychosis.

To assess whether long-term outcome of former drug abuse patients who had psychotic symptoms was related to duration of psychosis before hospitalization, the authors rated the psychiatric, occupational, and residential outcome of 101 former drug abuse patients based on interviews conducted ten years after their admission to a psychiatric hospital. At admission, 45 had had psychotic symptoms for six months or more; 26 had had psychotic symptoms for less than six months; and 30 had not been psychotic. Seventy-one former psychiatric patients who had had a psychotic illness but had not abused drugs were also interviewed and rated. Drug abusers with chronic psychosis had significantly worse psychiatric outcome than the other drug abusers and significantly worse occupational outcome than acutely psychotic drug abusers. The authors conclude that drug abusers with chronic psychotic symptoms are a distinct subgroup of drug abusers who suffer from major psychotic illness.

Acute Disease↗
PubMed1986

A low-cost environmental intervention for reducing smoking among cardiac inpatients.

Abstinence rates for smokers following a myocardial infarction or coronary artery bypass graft surgery may not be superior to those for nonpatient groups, and thus there is a need for novel approaches to smoking cessation in this population. The present study evaluated the effectiveness of using two sets of educational posters to reduce smoking among veterans in an inpatient cardiology unit's designated smoking area. One set of posters outlined the benefits of cessation (positive message) for cardiac patients while the other highlighted the risks of continued smoking (negative message). The positive posters had no consistent effect on indices of smoking, but the negative posters produced a substantial decline in both number of observed smokers and daily cigarette butts.

Coronary Disease↗
PubMed1986

Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.

The effects of immune complex formation on presentation was studied. Immune complexes between an IgG2a monoclonal anti-DNP antibody and TNP-KLH were produced, and the presentation of the carrier molecule by peritoneal macrophages to KLH-primed T cells was monitored. Complex formation was found to enhance the proliferative response of the T cells. This enhancement was specific, was not mediated by lymphokine release, and required antibody with an intact Fc portion. The significance of these results in terms of immune regulation and antigen presentation is discussed.

Animals↗
PubMed1985

The synergistic effect of smoking and serum cholesterol on coronary heart disease.

Cigarette smoking is a strong predictor of coronary heart disease (CHD), but much of the variance in determining which smokers will, and which will not, suffer from CHD remains unexplained. This review examines evidence of a synergistic interaction effect of smoking and elevated serum cholesterol on CHD morbidity and mortality. Evidence is also presented to support the notion that, in part, serum cholesterol, like smoking, is an index of a behavioral risk factor. Such a synergistic interaction is determined to exist, although improvements in methodology are needed to more clearly identify its magnitude. The review suggests that behavioral treatments aimed at smoking cessation and dietary modification should be focused specifically on the more than 25 million young and middle-aged Americans who smoke and have elevated serum cholesterol. In this way, such treatments may increase their effectiveness in lowering the risk of CHD (benefit) without necessarily increasing their effort (cost).

Body Weight↗