Biomedical subjects

K A Shaw

Publications and source records attributed to K A Shaw.

3 recordsLinked to original sources

PubMed2002

Attitudes and practices of general practitioners in the diagnosis and management of attention-deficit/hyperactivity disorder.

OBJECTIVE: To assess understanding of, and actual and potential roles in management of attention-deficit/hyperactivity disorder (ADHD) among GPs. METHODS: A cross-sectional questionnaire survey of Queensland GPs selected randomly from the Royal Australian College of General Practitioners directory of members was carried out. Main outcome measures were knowledge levels of ADHD, current management practices, referral patterns and self-perceived information and training needs. RESULTS: Three hundred and ninety-nine GPs returned a completed questionnaire (response rate 76%). Roles identified by GPs were: the provisional diagnosis of ADHD and referral to specialist services for confirmation of the diagnosis and initiation of management; assistance with monitoring progress once a management plan was in place; education of the child and their family regarding the disorder; and liaison with the school where necessary. Perceived barriers to increased involvement of GPs were: time and resource constraints of general practice; concerns regarding abuse and addiction liability of prescription stimulants; complex diagnostic issues associated with childhood behavioural problems; and lack of training and education regarding ADHD. CONCLUSIONS: General practitioners identify a role for themselves in ADHD care that is largely supportive in nature and involves close liaison with specialist services.

Adult↗

PubMed2000

Radical pruning: a method to construct skeleton radial basis function networks.

Trained radial basis function networks are well-suited for use in extracting rules and explanations because they contain a set of locally tuned units. However, for rule extraction to be useful, these networks must first be pruned to eliminate unnecessary weights. The pruning algorithm cannot search the network exhaustively because of the computational effort involved. It is shown that using multiple pruning methods with smart ordering of the pruning candidates, the number of weights in a radial basis function network can be reduced to a small fraction of the original number. The complexity of the pruning algorithm is quadratic (instead of exponential) in the number of network weights. Pruning performance is shown using a variety of benchmark problems from the University of California, Irvine machine learning database.

Algorithms↗

PubMed1991

The rabbit retina: a long-term model system for aluminum-induced neurofibrillary degeneration.

Aluminum (Al) was injected into the rabbit eye as a potential long-term model system for Al-induced neurofibrillary degeneration (NFD). Neurofibrillary tangles made up of 10 nm phosphorylated neurofilaments were observed in a subpopulation of retinal ganglion cells, located primarily in the peripheral retina. The distribution of affected cells suggested a differential susceptibility of ganglion cells to Al intoxication. Importantly, none of the animals demonstrated any of the central neurological dysfunctions characteristic of previous Al intoxication models. The retinal model should allow for long-term studies of Al intoxication and its potential relationship to neurofibrillary degenerative disorders such as Alzheimer's disease.

Aluminum↗