Biomedical subjects

K Abdallah

Publications and source records attributed to K Abdallah.

3 recordsLinked to original sources

PubMed2001

Modified Burch colposuspension: laparoscopy versus laparotomy.

STUDY OBJECTIVE: To compare results of laparoscopic Burch colposuspension with those of classic Burch colposuspension, and to assess complications, results, and morbidity associated with each procedure. DESIGN: Prospective, randomized study (Canadian Task Force classification I). SETTING: Minimal access surgery unit. PATIENTS: Seventy-four women with genuine stress incontinence. INTERVENTION: Laparoscopic and classic Burch colposuspensions. MEASUREMENTS AND MEAN RESULTS: Mean operating times for laparoscopic and open surgery were 70.18 +/- 16.54 and 53+/- 10.05 minutes, respectively (p <0.001). Mean blood loss was 42.75 +/- 7.2 and 240.5 +/- 35.5 ml, respectively (p <0.001). Postoperative analgesia requirement was significantly less with laparoscopy (p <0.001). Mean postoperative hospital stay was 36 +/- 6.3 hours for the laparoscopic group and 76+/- 10.4 hours for the open group p<0.001). Average time to return to light work was 8.5 and 31.5 days, respectively. Success rates were 90.9% at 6 months and 87.9% at 18 months in the laparoscopic group, compared with 90% and 85%, respectively, in the open group. CONCLUSION: Given equal efficacy of the two procedures, we prefer the laparoscopic approach since it is associated with lower morbidity, shorter hospital stay, and fewer complications. (J Am Assoc Gynecol Laparosc 8(1):99-106, 2001)

Adult↗

PubMed2000

Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis.

The mechanisms of chronic disease and recovery from relapses in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, are unknown. Deletion of myelin-specific lymphocytes by apoptosis may play a role in termination of the inflammatory response. One pathway of apoptosis is the passive cell death or "cell death by neglect" pathway, which is under the control of the Bcl family of genes. To investigate the role of passive cell death pathway in EAE, we used mice with transgenic expression of the long form of the bcl-x gene (Bcl-x(L)) targeted to the T-cell lineage. We found that mice transgenic for Bcl-x(L) have an earlier onset and a more chronic form of EAE induced by myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 compared with wild-type littermate mice. This was not due to an expanded autoreactive cell repertoire. Primed peripheral lymphocytes from Bcl-x(L) transgenic mice showed increased proliferation and cytokine production to MOG peptide in vitro compared with lymphocytes from wild-type animals. Immunohistologic studies demonstrated increased cellular infiltrates, immunoglobulin precipitation, and demyelination in the Bcl-x(L) transgenic central nervous system (CNS) compared with controls. There was also a decreased number of apoptotic cells in the CNS of Bcl-x(L) transgenic mice when compared with littermates at all time points tested. This is the first report of an autoimmune disease model in Bcl-x(L) transgenic mice. Our data indicate that the passive cell death pathway is important in the pathogenesis of chronic EAE. These findings have implications for understanding the pathogenesis of multiple sclerosis and other autoimmune diseases.

Amino Acid Sequence↗

PubMed1983

Evaluation of the impact of oral rehydration therapy on the outcome of diarrheal disease in a large community.

Diarrheal diseases are a serious public health problem in the Gaza Strip, being the most important cause of hospitalization in infants and responsible for about half of postneonatal deaths, Oral rehydration therapy using oral rehydration solution (ORS), a formula recommended by WHO, has been proven effective in the treatment of dehydration in acute childhood diarrhea. The availability of a well-organized health service in Gaza provided an excellent opportunity to institute a large-scale project to evaluate the effectiveness of early ORS therapy in reducing diarrhea-related hospital admissions, mortality and malnutrition. A 3-year program was started in 1979, encompassing all community health centers and including intensive community education in the use of ORS. Compared with the prestudy year 1977, diarrhea-related hospital admissions were reduced by 35.3% in 1980 and 42.0% in 1981; hospital deaths from diarrheal diseases were reduced 34.4 and 37.4% in 1980 and 1981, respectively. Total deaths in the 0- to 3-year age-group were reduced by 28.7% in 1980 and by 41.7% in 1981. Diarrheal mortality was reduced by 35.6% in 1980 and 53.2% in 1981. This study succeeded in establishing active community and family participation.

Child, Preschool↗