Myeloma of the heart.
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Atrial Fibrillation↗
Biomedical subjects
K Atkinson
Publications and source records attributed to K Atkinson.
Intramolecular catalysis. 3. Catalysis by oxygen-containing groups in the acetylation of hydroxy steroids.
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17-Hydroxycorticosteroids↗
Effects of acute respiratory acid-base alterations and inorganic phosphate (Pi) infusion on red cell 2,3-diphosphoglycerate (DPG) and P 50 in dogs.
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Acid-Base Equilibrium↗
Red cell alloantibodies produced after bone marrow transplantation.
This article describes the production of red cell alloantibodies in 13 of 150 patients after bone marrow transplantation. New alloantibodies appeared 12 days to 11 months after the transplantation. The specificities of these antibodies were anti-N, -Jka, -E-like, -Kell-like, -M, -Leb, -Hl, -H and -A1. The posttransplantation production of antibody could be due to either the transfusion of mature lymphocytes along with the marrow, the ability of the grafted immune system to produce alloantibodies, or the viable immunocompetent cells remaining despite high-dose chemotherapy and irradation.
Antibody Formation↗
A public health response to emerging technology: expansion of the Massachusetts newborn screening program.
The development of a new technology, called tandem mass spectrometry (tandem MS), has challenged governments worldwide to consider expanding universal newborn screening for rare metabolic disorders. In 1997 the Massachusetts Department of Public Health developed a public process to meet this challenge. After addressing significant medical, legal, ethical, and logistical issues raised by tandem MS, Massachusetts incorporated one new disorder into the mandatory newborn screen and developed an optional pilot program for 20 additional disorders. The Massachusetts experience has wide relevance for other nations and states. As screening protocols are contemplated for entire populations-for newborns and others- it will remain essential that the public participate in an open process of reviewing the justification for and logistics of screening.
Ethics, Medical↗
Evaluation of the endomysial antibody for celiac disease: operating properties and associated cost implications in clinical practice.
OBJECTIVE: To evaluate the operating properties of endomysial antibodies (EMAs) in the diagnosis of celiac disease and to examine, using a cost minimization model, different strategies used in the diagnosis of celiac disease. METHODS: A total of 248 EMA results were reviewed and compared with small bowel biopsy results in 66 patients who had undergone both tests. Regression analysis was used to look for predictors of positive EMA results and positive biopsy results. A cost minimization model from a societal perspective was used to evaluate the cost differences among three different strategies. RESULTS: EMAs had a sensitivity of 95% and specificity of 64%. The only predictor of a positive biopsy result that reached statistical significance was a positive EMA. The strategy of EMA as a diagnostic test for celiac disease was the most expensive strategy, with a cost of $3,174 per patient assessed. The strategy of small bowel biopsy for all patients had a cost of $997, and a strategy of EMA followed by small bowel biopsy for positive patients had a cost of $866 per patient. The results were sensitive to cost of a gluten-free diet, the specificity of the EMA and the cost of a small bowel biopsy. CONCLUSION: The EMA is best used as a screening test from both a clinical and cost perspective.
Adolescent↗
Conditioned medium from a cell strain derived from a patient with mastocytosis induces the development of mature human mast cells in vitro from normal human bone marrow.
Mature human mast cells were obtained from human bone marrow in a coculture system using conditioned medium from a human mastocytosis cell strain. These cells expressed the high-affinity IgE receptor and were tryptase, chymase and carboxypeptidase positive.
Biomarkers↗
Failure of patients to attend a medical outpatient clinic.
Failure of patients to attend outpatient clinics is common and costly. In one consultant's general medical and gastrointestinal outpatient clinic, 38% of new patients failed to keep at least one appointment, 17% did not attend for their first outpatient consultation and, of these, 59% failed to keep a second appointment sent to them. Of the patients who did attend for their first consultation 12% did not keep their next two appointments. Failure to attend was more common in men, young patients, patients from certain inner city areas, patients on the lists of certain general practices, and those who had already defaulted once. Possible background reasons for default are discussed, suggestions for further study proposed, and an attempt made to look for ways to reduce the extent of the problem.
Adolescent↗