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Biomedical subjects

K Augensen

Publications and source records attributed to K Augensen.

13 recordsLinked to original sources
PubMed1995

Treatment of ectopic pregnancy by local injection of hypertonic glucose: a randomized trial comparing administration guided by transvaginal ultrasound or laparoscopy.

OBJECTIVE: To study local treatment of ectopic pregnancy by injection of hyperosmolar (50%) glucose, guided either by transvaginal ultrasound or by laparoscopy. METHODS: Eighty women were randomized, 39 into the sonography and 41 into the laparoscopy group. Criteria for inclusion were 1) ectopic pregnancy < or = 4 cm seen by transvaginal ultrasound, 2) hCG < or = 3000 IU/l, and 3) little or no intraabdominal bleeding. In the sonography group, patients were treated by one skilled ultrasound investigator, whereas injections by laparoscopy were performed by several colleagues. The former group were offered a second glucose injection if hCG levels were rising. Those successfully treated were offered hysterosalpingography (HSG) for evaluation of tubal patency. RESULTS: Twenty-nine (74.4%) women were successfully treated in the sonography group by one single injection, compared to 21 (51.2%) in the laparoscopy group. Eight women in the sonography group received a second glucose injection because of a rising hCG, increasing the success rate in this group to 82.1% (32 of 39 women). Six patients in the laparoscopy group were not injected due to technical difficulties during the operation, and the success rate for those injected were 60% (21 of 35 women). The overall success rate was 66.3%. Of the 28 women investigated by HSG, both tubes were normal in 19 (67.8%), and in 25 patients (89.3%) the treated tube was open. CONCLUSIONS: Local injection of hyperosmolar glucose guided by transvaginal ultrasound by one skilled investigator is an effective treatment for ectopic pregnancy. Most women preserve tubal patency after treatment.

Administration, Topical↗
PubMed1994

The outcome of pregnancy following untreated impaired glucose tolerance.

OBJECTIVE: To study the outcome of untreated impaired glucose tolerance (IGT) during pregnancy. METHODS: Two hundred twelve pregnant women with IGT and 212 pregnant women with normal glucose tolerance. The main outcomes at delivery were mean gestation at delivery, incidence of preterm labor and induction of labor, modes of delivery, mean birthweight, mean Apgar score at 5 min, proportion of babies admitted to NICU, mean values of neonatal capillary blood glucose and hematocrit at 2 h of age. RESULTS: The mean age and parity of women with IGT during pregnancy were higher than those in control women. Their babies were heavier and had lower neonatal capillary blood glucose and higher hematocrit concentration than controls. However, the proportion of babies with birthweight > or = 2 S.D. above the mean, neonatal capillary blood glucose < 1.5 mmol/l (28 mg/dl) or hematocrit > or = 65% were equal in both groups. CONCLUSION: IGT, as defined by the World Health Organization, did not result in any adverse outcomes.

Adult↗
PubMed1987

Randomised comparison of early versus late induction of labour in post-term pregnancy.

In a prospective randomised study of mothers referred for prolonged pregnancy (around the 42nd week) 214 (group 1) were submitted to attempted induction of labour and 195 (group 2) assigned to continue for a further week without intervention. Strict selection criteria were used for the certainty of term. Mothers in group 2 were given regular non-stress tests to ensure fetal wellbeing, as were those in group 1 in whom induction failed. In group 1, 48 (23%) out of 210 first attempted inductions failed. In group 2, 135 (69%) of the births started spontaneously as compared with 38 (18%) in group 1. The mean duration of labour was 7.5 hours in each group. There was no significant difference in incidence of operative delivery, use of analgesics, or signs of perinatal asphyxia. Significantly more children in group 1 needed phototherapy for hyperbilirubinaemia. There was a clustering of births in the late afternoon and evening, which was most pronounced in group 1. A policy of vigilant non-intervention up to the 44th completed week of pregnancy does not appear to jeopardize mother or fetus.

Anthropometry↗
PubMed1984

Maternal mortality in the Nordic countries 1970-1979.

There are approximately 400,000 births plus legal abortions in the five Nordic countries annually. During the 1970s the number of maternal deaths ranged from 14 to 33 per year, the overall mean rate being 7.2 per 100,000 births. The rates declined somewhat from 1972 onwards, but otherwise there was no demonstrable change in frequency with time. Mortality rose steeply with increasing maternal age, with a rate of 28.5 for mothers over 35. The two most frequent causes of death were pre-eclampsia/eclampsia and hemorrhage, comprising 17.0 and 14.2% of the total, respectively. Legal abortion carried less risk of death than did pregnancy continuing to birth. Among the countries, Denmark and Sweden had the lowest average maternal mortality rates. The distribution of causes showed a predominance of abortion and thrombosis in Finland, and of hemorrhage and infection in Norway, but neither singular causes nor age-specific birth distributions can explain inter-country differences.

Abortion, Induced↗
PubMed1983

Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte protoporphyrin determinations.

Serum iron, serum iron-binding capacity, serum ferritin and erythrocyte protoporphyrin were determined during uncomplicated pregnancy in 45 healthy women; 22 were given oral iron while the others were given a placebo. When iron was not given, 15 out of 23 women had exhausted iron stores and iron deficiency at term, as judged from low serum ferritin, low serum transferrin saturation and high erythrocyte protoporphyrin values. Only seven of them had a haemoglobin concentration between 10 and 11 g/dl at term but none had values less than 10 g/dl. In the iron-treated group (n = 22) none of the women developed iron deficiency. Serum ferritin was the most sensitive and specific test of iron deficiency. A practical procedure to detect iron deficiency and to control iron supplementation in pregnancy is suggested.

Adult↗
PubMed1983

Serum protein pattern in normal pregnancy with special reference to acute-phase reactants.

The concentrations of acute-phase protein reactants, total protein, albumin and globulin fractions were measured throughout normal pregnancy in 27 women. alpha 1-Antitrypsin and caeruloplasmin concentrations increased gradually to reach their highest levels in the third trimester. Orosomucoid and haptoglobin showed similar patterns: higher levels in the first and third trimester with a decline around 24 weeks gestation. C-Reactive protein showed levels similar to those of non-pregnant healthy individuals (less than 5 mg/l) throughout pregnancy. alpha 1-, alpha 2- and beta-Globulin concentrations increased from the first trimester towards term. gamma-Globulin concentration changed little during gestation. The data obtained provide reference ranges for serum proteins in healthy pregnancy.

Adult↗
PubMed1983

Unruptured tubal pregnancy at term with survival of mother and child.

A case of tubal pregnancy going to term and resulting in a living child is presented. Problems in diagnosis include differentiation from an ovarian cyst concomitant with intrauterine pregnancy. Although the literature offers radiologic diagnostic signs, radiologic examination did not indicate ectopic pregnancy, and the diagnosis was made at laparotomy for cesarean section.

Adult↗