Metastasizing basal cell carcinoma.
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Adult↗
Biomedical subjects
K B Alonso
Publications and source records attributed to K B Alonso.
Detection of prethrombotic and thrombotic states.
Newer methods for detecting subclinical thrombosis are discussed. Uses of radionuclides for thrombus localization are reviewed. Laboratory tests suitable for nonspecialized laboratories are highlighted. The serial use of functional antithrombin III and ethanol gelation assays are recommended to follow the effect of anticoagulant therapy. The use of heparin therapy in low dosage is discussed.
Antithrombin III↗
The seial thrombin time in the diagnosis of consumptive coagulopathy.
Acute consumptive coagulopathy may be initiated by diverse events. It is frequently necessary to establish the diagnosis with urgency. Rational therapy can only be approached with knowledge of the relative impact the primary consumption exerts upon hemostasis as well as the effects of secondary fibrinolysis. A constellation of interlocking tests within the capability of the small laboratory is presented. This includes the prothrombin time, the activated partial thromboplastin time, the serial thrombin time, the heat precipitation fibrinogen level, the platelet count, red cell morphology, the levels of fibrin (fibrinogen) degradation products and selected factor assays. This series can be completed within 45 minutes. Interpretation, with particular emphasis upon the stage in the natural history of the process when evaluation is instituted, and underlying diseases which modify typical patterns are discussed. The discriminant function of the serial thrombin time is stressed.
Adult↗
Evaluation of methods for measurement of steroid hormone receptors.
Several factors affecting estrogen receptor assays have been investigated. Pools of rabbit uterus cytosol and human tumor cytosol were utilized to minimize sampling error. Optimum concentration of diethylstilbestrol was found to be 1000 times the highest labeled ligand concentration. Dithiothreitol (DTT) and ionic strength had no effect on receptor value in human tumor cytosols. Optimum pH for estrogen receptor assay is 7.78.
Animals↗