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Biomedical subjects

K B Krasil'shchikov

Publications and source records attributed to K B Krasil'shchikov.

9 recordsLinked to original sources
PubMed1983

[Effect of kappa-casein glycomacropeptide on gastrointestinal motility in dogs].

Glycomacropeptide, which provoked a significant inhibition of food motility of the stomach fundus on intravenous injection to dogs in a dose of 10 mg, was isolated from the products of restricted pepsin proteolysis of cow kappa-casein with the aid of gel chromatography on Sephadex G-25 and G-10. Glycomacropeptide administered on an empty stomach produced cyclic-repetitive vomiting. Physiological action of glycomacropeptide (inhibition of gastric secretion and motility) may play an important role in the preservation of biologically active milk proteins and peptides in the gastrointestinal tract of the newborn.

Animals↗
PubMed1977

[Character of Auerbach's plexus receptors in the stomach and small intestine].

The motility of the stomach and jejunum in 8 fed dogs with the intact vagus nerves was registered by the balloon method. Subcutaneous injection of benzohexonium (0.125--0.5 ml of 2.5% soltuion) and atropine (0.12--0.25 ml of 0.1% solution) or metacine (0.125--0.25 ml of 0.1% solution) to 6 dogs proved to induce a transition from digestive motility to the periodic form after a transient depression of the digestive motility. The same effect followed injection of 0.5--1.0 ml of 0.1% atropine only in 2 dogs and 1.0 ml of 0.1% metacine in 1 dog. Since retention of periodic motility following food consumption was inherent for vagotomized dogs, a conclusion was drawn that the experimental dog had "pharmacologic vagotomy". It was suggested that the muscarine receptors on the Auerbach's plexus cells exceeded the nicotine receptor in number.

Animals↗
PubMed1975

[Influence of methochlopramide on the motor function of the esophagus and the cardial sphincter].

In acute experiments on cats and in chronic experiments on dogs the contractile activity of the esophagus and the cardiac sphincter was recorded with a ballon pulled from the stomach to the esophagus connected to a catheter. The intravenous injection of Metoclopramide in doses of 0.5--0.6 mg/kg to cats and subcutaneous injection of Metoclopramide in doses of 0.1--0.15 mg/kg to dogs elevated the pressure in the cardiac sphincter significantly increased the motility of the distal esophagus and stimulated the esophago-gastric inhibitory reflex. These effects persisted for 2.5--3 hrs; they were phasic in nature and were preserved after vagotomy in dogs. A conclusion was drawn that Metoclopramide could be useful in pathology of the distal esophagus, including the cardiac sphincter.

Animals↗
PubMedDate not supplied

[Effect of reasec on the motor function of the esophagus and cardiac sphincter in cats].

Acute experiments with cats demonstrated that intravenous injection of reasec in doses of 0.25-0.45 ml/kg inhibits the contractile activity of the smooth muscles part of the esophagus, including the cardiac sphincter. The motoricity in the proximal sections of the esophagus formed by the striated muscles did not change against the background of the reasec's action.

Animals↗
PubMedDate not supplied

[Effect of ATP on the contractile activity of different sections of the digestive tract].

In chronic tests on fistulized dogs ATP only with its intravenous administration, starting from a dose of 0.33 mg/kg inhibited motility of the stomach, small and large intestines. The intensity and duration of the inhibitory effect depended on the dose of ATP administered, but beginning from the dose of 0.09 mg/kg the effect of saturation started developing. The adrenoblocking agents phentolamine and inderal, the sympatholytics isobarin and ornidum did not eliminate the inhibitory action of ATP. The latter effectively suppressed the periodic and food motility of the gastrointestinal tract, as well as the motility induced by the insulin-produced hypoglycemia, by carbacholine and methoclopramide.

Adenosine Triphosphate↗